TAB1 Produkte
(TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1))
Kategorien
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
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Ausgewählte TAB1 Kategorien
TAB1 Antikörper
High quality antibodies with extensive validation data.
TAB1 ELISA Kits
Reliable ELISA kits for a wide range of species.
TAB1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene TAB1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IF, PLA
Validierungen
- (6)
Kat. Nr.
ABIN564552
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC
Validierungen
- (4)
Kat. Nr.
ABIN7171965
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA
Validierungen
- (3)
Kat. Nr.
ABIN523851
Menge
200 μL
Datenblatt
Datenblatt
Empfohlene TAB1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6970603
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN2951746
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6229502
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene TAB1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (3)
Kat. Nr.
ABIN7544156
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
HEK-293 Cells
Validierungen
- (3)
Kat. Nr.
ABIN7559296
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7125344
Menge
50 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren TAB1 Produkten
: "MicroRNA 27a-3p Regulates Antimicrobial Responses of Murine Macrophages Infected by Mycobacterium avium subspecies paratuberculosis by Targeting Interleukin-10 and TGF-β-Activated Protein Kinase 1 ..." in: Frontiers in immunology, Vol. 8, pp. 1915, (2017) (PubMed).: "Insights into O-linked N-acetylglucosamine ([0-9]O-GlcNAc) processing and dynamics through kinetic analysis of O-GlcNAc transferase and O-GlcNAcase activity on protein substrates." in: The Journal of biological chemistry, Vol. 287, Issue 19, pp. 15395-408, (2012) (PubMed).
: "PRAK is essential for ras-induced senescence and tumor suppression." in: Cell, Vol. 128, Issue 2, pp. 295-308, (2007) (PubMed).
: "Determinants that control the specific interactions between TAB1 and p38alpha." in: Molecular and cellular biology, Vol. 26, Issue 10, pp. 3824-34, (2006) (PubMed).
: "TAK1-binding protein 1 is a pseudophosphatase." in: The Biochemical journal, Vol. 399, Issue 3, pp. 427-34, (2006) (PubMed).
: "Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex ..." in: The Journal of biological chemistry, Vol. 280, Issue 8, pp. 7359-68, (2005) (PubMed).
: "Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice." in: Cancer research, Vol. 64, Issue 20, pp. 7183-90, (2004) (PubMed).
: "Toll-like receptor signalling." in: Nature reviews. Immunology, Vol. 4, Issue 7, pp. 499-511, (2004) (PubMed).
: "TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2." in: Nature, Vol. 416, Issue 6878, pp. 345-7, (2002) (PubMed).
: "Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol." in: Molecular and cellular biology, Vol. 22, Issue 20, pp. 7158-67, (2002) (PubMed).
Synonyme und alternative Namen zu TAB1
TGF-beta activated kinase 1 (MAP3K7) binding protein 1 (TAB1), TGF-beta activated kinase 1/MAP3K7 binding protein 1 (Tab1), 3'-Tab1, 2310012M03Rik, b2b449Clo, MAP3K7IP1, Map3k7ip1Bezeichner auf Proteinebene für TAB1
- TAK1-binding protein 1
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
- mitogen-activated protein kinase kinase kinase 7-interacting protein 1
- transforming growth factor beta-activated kinase-binding protein 1
- TGF-beta-activated kinase 1-binding protein 1
- Tak1-binding protein 1
- beta activated kinase-1 binding protein-1
- mitogen activated protein kinase kinase kinase 7 interacting protein 1
- mitogen-activated protein kinase kinase kinase 7 interacting protein 1
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