anti-TAB2 (TAB2) Antikörper

Human TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) Interaktionspartner

1. The combination of WES, genomic triangulation, and systems biology has uncovered perturbations in TGF-beta activated kinase 1 (zeige MAP3K7 Antikörper) signaling as a novel pathogenic substrate for polyvalvular syndrome.

2. Data suggest that mRNA/protein levels of NLRP6 (zeige NLRP6 Antikörper) are down-regulated in synovial tissues and synoviocytes of rheumatoid arthritis (RA) patients compared to osteoarthritis patients; NLRP6 (zeige NLRP6 Antikörper) provides docking site to facilitate interaction between TAB2/3 and TRIM38 (zeige TRIM38 Antikörper) in RA synoviocytes in response to TNFalpha (zeige TNF Antikörper). (NLRP6 (zeige NLRP6 Antikörper) = ; TAB2/3 = transforming growth factor-b (zeige ATP5S Antikörper)-activated kinase 1-binding protein 2/3; TRIM38 (zeige TRIM38 Antikörper) = tripartite motif 38)

3. A Novel Functional Domain of Tab2 Involved in the Interaction with Estrogen Receptor Alpha (zeige ESR1 Antikörper) in Breast Cancer Cells

4. The expression of miR (zeige MLXIP Antikörper)-155 target gene, TAB2, and the downstream gene, iNOS (zeige NOS2 Antikörper), were found to be inhibited in psoriatic dermal mesenchymal stem cells.

5. DK1 (zeige DOLK Antikörper) inhibits the formation of the TAK1 (zeige MAP3K7 Antikörper)-TAB2-TRAF6 (zeige TRAF6 Antikörper) complex and leads to the inhibition of TRAF6 (zeige TRAF6 Antikörper) ubiquitination.

6. Authors demonstrate that enterovirus 71 3C interacts with TAB2 and TAK1 (zeige MAP3K7 Antikörper) and suppresses cytokine expression via cleavage of the TAK1 (zeige MAP3K7 Antikörper) complex proteins.

7. SUMOylation may serve as a novel mechanism for the regulation of TAB2.

8. conclude that TRIM38 (zeige TRIM38 Antikörper) negatively regulates TNFalpha (zeige TNF Antikörper)- and IL-1beta (zeige IL1B Antikörper)-induced signaling by mediating lysosome-dependent degradation of TAB2/3, two critical components in TNFalpha (zeige TNF Antikörper)- and IL-1beta (zeige IL1B Antikörper)-induced signaling pathways

9. These data indicate that overexpression of TRIM22 (zeige TRIM22 Antikörper) may negatively regulate the TRAF6 (zeige TRAF6 Antikörper)-stimulated NF-kappaB (zeige NFKB1 Antikörper) pathway by interacting with and degrading TAB2.

10. our data implicate Tab2 as a mediator of resistance to endocrine therapy and as a potential new target to reverse pharmacological resistance and potentiate antiestrogen action.

Mouse (Murine) TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) Interaktionspartner

1. These findings support a regulatory role for TGF-beta-activated kinase 1 (zeige MAP3K7 Antikörper) in governing downstream MAPKs/NF-kappaB (zeige NFKB1 Antikörper) signaling cascades in the macrophage activation in response to hyperglycemic insult

2. RNF4 (zeige RNF4 Antikörper) negatively regulates NF-kappaB (zeige NFKB1 Antikörper) signaling by down-regulating TAB2

3. TAB1 (zeige TAB1 Antikörper) and TAB2 are required for activated macrophages, making TAB1 (zeige TAB1 Antikörper) and TAB2 effective targets to control inflammation by modulating macrophage survival.

4. Loss of Tab2 is associated with liver injury.

5. miR (zeige MLXIP Antikörper)-155 inhibits the immunosuppressive capacity of MSCs by reducing iNOS (zeige NOS2 Antikörper) expression by targeting TAB2.

6. TAB2 and TAB3 (zeige TAB3 Antikörper) are essential for B cell activation (zeige BLNK Antikörper) leading to antigen-specific antibody responses, as well as B-1 and marginal zone B cell development.

7. We found that endothelial TAK1 (zeige NR2C2 Antikörper) and TAB2, but not TAB1 (zeige TAB1 Antikörper), were critically involved in vascular formation

8. MiR (zeige MLXIP Antikörper)-23b suppresses IL-17 (zeige IL17A Antikörper)-, tumor necrosis factor alpha (TNF-alpha (zeige TNF Antikörper))- or IL-1beta (zeige IL1B Antikörper)-induced NF-kappaB (zeige NFKB1 Antikörper) activation and inflammatory cytokine expression by targeting TAB2, TAB3 (zeige TAB3 Antikörper) and IKK-alpha (zeige CHUK Antikörper).

9. Epithelial TAK1 (zeige NR2C2 Antikörper) activity is regulated through two unique, TAB1 (zeige TAB1 Antikörper)-dependent basal & TAB2-mediated stimuli-dependent mechanisms.

10. TAK1 (zeige NR2C2 Antikörper) and its adapter protein (zeige GRB10 Antikörper), TAB2, reciprocally regulate both TAK1 (zeige NR2C2 Antikörper)- and ASK1 (zeige MAP3K5 Antikörper)-mediated signaling pathways to direct the activations of NF-kappaB (zeige NFKB1 Antikörper) and AP-1 (zeige JUN Antikörper).

Zebrafish TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) Interaktionspartner

1. a critical, dosage-sensitive role during development was demonstrated by the cardiac defects observed upon titrated knockdown of tab2 expression in zebrafish embryos