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Overall, this study reveals the heterogeneity of CD4 effector memory T cells expressing CD45RA and provides insights into T-cell responses against dengue virus and other viral pathogens.
Five-year disease-free survival for patients with a high transcriptional expression of CD45 (n = 107) was 62.4% and for patients with a low expression (n = 53) it was 36.2% (P = 0.003). Patients with a high expression of CD45 had a better local recurrence-free survival and disease-specific survival.
CD45 is a regulator of IL-2 synergy in the NKG2D-mediated activation of immature human NK cells
TCR phosphorylation negatively correlates with TCR-CD45 separation.
Our results demonstrate that the expression of CD163 and CD206 in monocytes is modulated by LPS in vitro; LPS induces CD163 expression and downregulates the spontaneously increased expression of CD206
Our results show that the kinetic strategy used in this study may be a simple and easy approach to assess by RT-FCM the reaction between NO and superoxide ion in whole blood monocytes..The no-wash, no-lyse staining protocol with CD45-KO and CD14-PB allows to differentiate clearly and to gate in the monocyte population in near-physiological conditions
regulatory effect of the mannose receptor (MR) was mediated by a direct interaction with CD45 on the T cell, inhibiting its phosphatase activity, which resulted in up-regulation of CTLA-4 and the induction of T-cell tolerance. Inhibition of CD45 prevented expression of B-cell lymphoma 6 (Bcl-6), a transcriptional inhibitor that directly bound the CTLA-4 promoter and regulated its activity
pUL11 induces IL-10 producing T cells as a result of pUL11 binding to the CD45 phosphatase on T cells.
Expression of IL10R subunits within the leukocyte population (CD45(+) cells) was significantly higher in primary brain tumors than in metastases.
As CD45 expression vs. SSc is routinely measured in the diagnostics of acute leukemias.
A phosphosite within the SH2 Domain of Lck regulates its activation by CD45. A negative feedback loop that responds to signaling events tunes active Lck amounts and TCR sensitivity.
C77G is not associated with ovarian cancer in the Norwegian population. However, it is possibly associated with a less aggressive cancer type.
Our findings suggest that CD45 is a key regulator of BCR-signaling thresholds mediated by T-cell help
we demonstrate for the first time the physiological existence of ct-CD45 in human plasma and show that it may be an extrinsic factor contributing to the maintenance of human T-cell quiescence.
Our findings suggest that if w/h ratio on SSC versus CD45 plot is less than 1.6, AML may be considered, and if it is more than 1.6, ALL may be diagnosed. Using morphometric analysis of the blast cluster on SSC versus CD45, it was possible to distinguish between ALL and AML, and their subtypes.
Use of the common leukocyte marker CD45 increases the sensitivity of the diagnosis of lymphocytic myocarditis.
Review/Meta-analysis: Rheumatoid arthritis patients with PTPRC rs10919563 A allele show a poor response to anti-TNF therapy.
Data suggest that CD41 and CD45 expression marked the onset of haemangioblastoma (HB) neovascularisation and the stepwise development of the angioformative period, and also the underlying therapeutic targets of anti-vascular treatment.
PTPRC has become the most replicated genetic biomarker of response to TNF inhibitors
CD45RO in tumor-infiltrating lymphocytes was found to be a positive prognostic factor in squamous non-small cell lung cancer.
A point mutation in the natural cytotoxicity receptor 1 (Ncr1) locus fortuitously identified in the CD45.1 strain.
This work validates targeting CD45 phosphatase enzymatic activity, which may be a druggable target for cancer therapy.
Inhibition by high CD45 on CD8(+) T cells may protect against overt T-cell receptor (TCR) auto-MHC reactivity.
this study shows that CD45 positioning within lipid rafts is modified during their oncogenic transformation to acute myeloid leukemia
Data show that CD45(+) uncultured adipose tissue derived stromal cells (u-ADSCs) acting phenotypically and functionally like M2-type macrophages (MPhis), contributed to the repair of liver tissue undergoing inflammation.
We identify differing roles for the phosphatase CD45 in innate and adaptive immune cells in intestinal inflammation. CD45 is required for optimal GM-CSF and RA production in innate immune cells that affects alpha4beta7 expression and the homing of effector T cells to the intestine. Conversely, the absence of CD45 on adaptive immune cells leads to enhanced alpha4beta7 expression on T cells and homing to the intestine.
T cell receptor / TLR2 co-stimulation expands CD25+CD45Rbhi T cells.
Both the number of lung CD31-CD45-Sca-1+ cells and the expression levels of the Shh signaling pathway were downregulated in the lung tissues of mice with pulmonary emphysema. These cells and Shh signaling pathway are reactivated during acute adenovirus infection.
the transient upregulation of IL-1beta and PTPRC/CD45 during the early phase as well as the increased expression of collagen type I at later stages of repair and validate the differential expression of miR-204, miR-205, and miR-31 in skin wounds.
Increased numbers of CD4(+)CD45RA(-)FoxP3(low) cells may cause an imbalance between Treg and Th17 cells that is mainly localized to the colon.
Aging induces loss of stemness with concomitant gain of myogenic properties of a pure population of CD34+/CD45- muscle derived stem cells.
deletion of Pten in CD45-expressing cells induces development of T-cell acute lymphoblastic leukemia and lymphoma, but not other hematologic malignancies
A noncatalytic role for CD45 in regulating tonic, but not antigen-mediated, B-cell antigen receptor (BCR) signaling through modulation of the function of the inhibitory coreceptor CD22, was identified.
data demonstrate that the CD45E613R mutation modulates integrin activation and leukocyte recruitment during inflammation.
CD45 ligation specifically reduced Treg motility in an integrin-dependent manner, resulting in enhanced interactions between Tregs and DCs in vivo.
Data (including data from genome-wide mutagenesis studies) suggest that nonsense mutation in Ptprc is a susceptibility trait for herpes simplex encephalitis due to Herpesvirus 1; this effect appears to be mediated by Th1 cells and the brain stem.
These findings demonstrate a novel role for CD45 on innate immune cells in promoting lymphopenia-induced T cell proliferation and suggest that innate immune cells may communicate with stromal cells to regulate IL-7 production.
Expressing CD45 promoters containing these regions and tethered to green fluorescent protein (GFP) in a primary B-cell differentiation assay and a transplantation model resulted in high levels of GFP in lymphoid, myeloid, and nucleated erythroid cells
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
receptor-type tyrosine-protein phosphatase C
, leukocyte common antigen, CD45
, protein tyrosine phosphatase, receptor type, C
, CD45 antigen
, leukocyte common antigen
, receptor-type tyrosine-protein phosphatase C-like
, T200 glycoprotein
, T200 leukocyte common antigen
, protein tyrosine phosphatase, receptor type, c polypeptide
, lymphocyte antigen 5
, lymphocyte common antigen
, Protein tyrosine phosphatase, receptor-type, c polypeptide
, leucocyte common antigen
, leukocyte common antigen A
, leukocyte common antigen B
, membrane tyrosine phosphatase