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anti-Human CD73 Antikörper:
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Human Monoclonal CD73 Primary Antibody für FACS, IHC (fro) - ABIN4252052
Fend, Nachbaur, Oberwasserlechner, Kreczy, Huber, Müller-Hermelink: Phenotype and topography of human thymic B cells. An immunohistologic study. in Virchows Archiv. B, Cell pathology including molecular pathology 1991
Show all 14 Pubmed References
Chicken Polyclonal CD73 Primary Antibody für FACS, IF (cc) - ABIN1385637
Gao, Bai, Xiong, Li, Shan, Huang, Ma, Guan: Isolation and characterization of chicken dermis-derived mesenchymal stem/progenitor cells. in BioMed research international 2013
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Human Polyclonal CD73 Primary Antibody für IHC (p), WB - ABIN388750
Leth-Larsen, Lund, Hansen, Laenkholm, Tarin, Jensen, Ditzel: Metastasis-related plasma membrane proteins of human breast cancer cells identified by comparative quantitative mass spectrometry. in Molecular & cellular proteomics : MCP 2009
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Human Monoclonal CD73 Primary Antibody für FACS, MCA - ABIN1176840
Kögler, Sensken, Airey, Trapp, Müschen, Feldhahn, Liedtke, Sorg, Fischer, Rosenbaum, Greschat, Knipper, Bender, Degistirici, Gao, Caplan, Colletti, Almeida-Porada, Müller, Zanjani, Wernet: A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential. in The Journal of experimental medicine 2004
Show all 8 Pubmed References
Human Monoclonal CD73 Primary Antibody für FACS, MCA - ABIN1558084
Paquet-Fifield, Schlüter, Li, Aitken, Gangatirkar, Blashki, Koelmeyer, Pouliot, Palatsides, Ellis, Brouard, Zannettino, Saunders, Thompson, Li, Kaur: A role for pericytes as microenvironmental regulators of human skin tissue regeneration. in The Journal of clinical investigation 2009
Show all 7 Pubmed References
Human Monoclonal CD73 Primary Antibody für FACS, MCA - ABIN1027668
Semenov, Koestenbauer, Riegel, Zech, Zimmermann, Zisch, Malek: Multipotent mesenchymal stem cells from human placenta: critical parameters for isolation and maintenance of stemness after isolation. in American journal of obstetrics and gynecology 2010
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Human Polyclonal CD73 Primary Antibody für ICC, IF - ABIN4276930
Serra, Horenstein, Vaisitti, Brusa, Rossi, Laurenti, DArena, Coscia, Tripodo, Inghirami, Robson, Gaidano, Malavasi, Deaglio: CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death. in Blood 2011
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Human Monoclonal CD73 Primary Antibody für FACS - ABIN2192064
Airas, Salmi, Jalkanen: Lymphocyte-vascular adhesion protein-2 is a novel 70-kDa molecule involved in lymphocyte adhesion to vascular endothelium. in Journal of immunology (Baltimore, Md. : 1950) 1993
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Rat (Rattus) Monoclonal CD73 Primary Antibody für IHC (f), IHC (fro) - ABIN2689392
Gandhi, Le Hir, Kaissling: Immunolocalization of ecto-5'-nucleotidase in the kidney by a monoclonal antibody. in Histochemistry 1991
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Human Polyclonal CD73 Primary Antibody für IHC (p) - ABIN388749
Nadri, Soleimani, Mobarra, Amini: Expression of dopamine-associated genes on conjunctiva stromal-derived human mesenchymal stem cells. in Biochemical and biophysical research communications 2008
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The NT5E and ecto-adenosine deaminase (E-ADA )perform key functions in the modulation of the immune and inflammatory response in Systemic lupus erythematosus (SLE).
High CD73 expression is associated with head and neck squamous cell carcinoma.
Spindle-shaped gastric cancer stromal cells expressing CD73, CD90 or CD105 are involved in disease progression, and among them, CD105-positive cells are strongly associated with poor prognosis.
Changes in the local expression and activity of CD39 and CD73 in calcified valves suggest their potential role in calcific aortic valve disease.
High expression of NT5E is associated with Prostate Cancer.
Case Report: identify novel mutations in the NT5E gene in patient with calcification of joints and arteries.
High CD73 expression is associated with breast cancer.
High CD73 expression is associated with neoplasms.
NT5E-targeting miRNAs (miR-30b and miR-340) function as tumor suppressors
soluble CD73 might be used as serologic prognostic biomarker in patients with metastatic melanoma patients.
High CD73 expression is associated with the increase in the ability of surviving breast cancer cells to evade innate and adaptive immunity.
analysis of how inhibitors block human CD73 and block efficiently its enzymatic function in the low micromolar range through a non-competitive inhibition mechanism
The Ecto-5'nucleotidase, together with alkaline phosphatase, also expressed apically in oviductal epithelium, complete the hydrolysis sequence by dephosphorylating AMP to adenosine.
this paper shows that simultaneous overexpression of human E5NT and ENTPD1 protects porcine endothelial cells against H2O2-induced oxidative stress and cytotoxicity in vitro
high levels of CD73 are significantly associated with reduced overall survival in patients with head and neck squamous cell carcinoma
Studied role of miR-30a in colorectal cancer(CRC). Found miR-30a is downregulated in CRC, and it inhibits cell proliferation in CRC by reducing expression of CD73.
we demonstrated the existence of CSCs in both cultured ccRCC cell line and tissues, and CD73 as a cell-surface biomarker for ccRCC CSC-like cells.
Induction of ecto-5'-nucleotidase/CD73 by radiation contributes to the radiosensitivity of T24 urinary bladder cancer cell line.
Report prognostic impact of CD73 expression in non-small lung cancers.
Data show that MiR-422a and its target CD73 are involved in early loco(regional) recurrence of head and neck squamous cell carcinoma (HNSCC) tumors and are targets for personalized medicine.
enzymatic properties of an ecto-5'-nucleotidase activity in brain membranes of zebrafish
study concludes that dictyocaulosis alters NTPDase, 5'-nucleotidase, and ADA activities of cow naturally infected by the parasite Dictyocaulus viviparus, in consequence the enzymes act as inflammatory markers
Salmonella infection can down regulate CD73 expression in macrophages.Extracellular adenosine synthesized by CD73 suppresses antibacterial responses of macrophages, which may weaken macrophage function and impair innate immune responses to Salmonella infection.
TGF-beta-rich tumor milieu confers resistance to anti-4-1BB therapy by sustaining CD73 expression primarily on infiltrating CD8(+) T cells across several tumor models.
Deletion of CD73 in mice leads to aortic valve dysfunction similar to that induced by high-fat diet suggesting important role of this surface protein in maintaining heart valve integrity.
We establish that the mouse Nt5e minimal promoter transcriptional activity is negatively regulated by an Elf2-like Ets-related transcription factor in activated mouse liver myofibroblasts
CD73 derived adenosine production slows down migration of Langerin+ dendritic cells from skin to lymph nodes. This may be a crucial mechanism to avoid over boarding immune reactions against haptens.
Compared to adults, young WT mice failed to control S. pneumoniae infection after vaccination and this was associated with lower levels of CD73 on innate B cells. We hypothesized that pharmacological activation of A2a receptor may improve Pneumovax 23 immunization in young WT mice
The 5'-ectonucleotidase CD73 has a key role in regulating macrophage immune responses during efferocytosis by converting AMP released from apoptotic cells into adenosine to suppress multiple pro-inflammatory cytokines.
CD73 expression identifies a subset of IgM(+) antigen-experienced cells with memory attributes that is T cell and CD40 signalling dependent
findings demonstrate the critical role of CD73 in the regulation of infection by the enteric pathogen Salmonella and implicate adenosine as an important host-derived factor that mediates host-microbe interaction
Data show that AMP deaminase 3 (Ampd3)-/-/5'-nucleotidase (CD73)-/- knockout mice are more sensitive to AMP-induced hypometabolism than mice with a single enzyme deficiency, which are more sensitive than wild type.
This study evaluated the role of CD73 in the accumulation and adhesion of pulmonary macrophages in response to thoracic irradiation.
Deletion of CD39 and CD73 or both caused an inhibition of the microglia ramified phenotype in the brain with a reduction in the length of processes, branching frequency and number of intersections with Sholl spheres. In vitro, unlike wild-type microglia, cd39-/- and cd73-/- microglial cells were less complex and did not respond to ATP with the transformation into a more ramified phenotype.
CD73 expression is regulated during experimental autoimmune encephalomyelitis, this enzyme is not absolutely required to either promote or limit Th17 cell expansion or experimental autoimmune encephalomyelitis severity.
High NT5E expression is associated with Radiation-Induced Lung Fibrosis.
Ablation of CD73 minimally effects in vivo thrombosis, but increased CD39 expression on hematopoietic-derived cells, especially monocytes, attenuates in vivo arterial thrombosis.
CD73 on T cells plays an important anti-inflammatory role in transverse aortic constriction-induced heart failure
In this study, we investigated whether blockade of the A2A adenosine receptor with a selective antagonist and a CD73 inhibitor may increase the efficacy of a dendritic cell-based cancer vaccine
Data indicate that adenosine and CGS21680 upregulate CD39 and CD73 via E2F-1 and CREB.
CD73-siRNA-loaded ChLa NPs may be considered as a promising therapeutic tool for cancer therapy; however, further in vivo investigations are necessary
CD39 and CD73 and their enzymatic activities that convert extracellular nucleotides are highly expressed and could have special function in the valve
The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.
, Purine 5-Prime-Nucleotidase
, 5' nucleotidase, ecto
, 5'-nucleotidase, ecto (CD73)