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Human Polyclonal PRDM16 Primary Antibody für ELISA - ABIN249627
Stanford, Middelbeek, Townsend, An, Nygaard, Hitchcox, Markan, Nakano, Hirshman, Tseng, Goodyear: Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. in The Journal of clinical investigation 2013
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Human Polyclonal PRDM16 Primary Antibody für ELISA, ICC - ABIN4347210
Baskaran, Krishnan, Ren, Thyagarajan: Capsaicin induces browning of white adipose tissue and counters obesity by activating TRPV1 channel-dependent mechanisms. in British journal of pharmacology 2016
Prdm3 (zeige MECOM Antikörper) and prdm16 are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.
Animals with the homozygote PRDM16 genotype had lower body weight and average daily gain than those with the other genotypes.
The genetic variation within PRDM16 gene in 1031 Chinese indigenous bovine, was analyzed.
Multiple regression analysis showed that age, male gender, body max index, presence of obesity, type-2-diabetes mellitus, hypertension and coronary artery disease and left ventricular ejection fraction were associated with the expression levels of UCP1 (zeige UCP1 Antikörper), PGC1alpha and PRDM16 mRNA
Our study suggests that the MEF2D (zeige MEF2D Antikörper), PRDM16 and ASTN2 (zeige ASTN2 Antikörper) genes from GWAS are associated with migraine susceptibility, especially migraine without aura (zeige AURKA Antikörper) , among Chinese patients. It appears that there is no association with serotonin receptor (zeige HTR1B Antikörper) related genes.
High PRDM16 expression is a significant predictive marker for poor prognosis in adult AML (zeige RUNX1 Antikörper) patients.
Prdm16 interacts with the transcription factor Hlx (zeige HLX Antikörper), which is stabilized in response to beta3-adrenergic signaling, to increase thermogenic gene expression and mitochondrial biogenesis in subcutaneous WAT.
Flow cytometric analysis and western blot analysis of apoptosisassociated proteins indicated that PRDM16 has an antiapoptotic role in prostatic cancer cells. In addition, the spliced form, sPRDM16/MEL1S, was detected to be overexpressed in PCa (zeige FLVCR1 Antikörper) cell lines. In conclusion, the present study indicated an important oncogenic role in prostate cancer.
A single risk variant, rs2651899 in PRDM16, was significantly associated with efficacy of triptans in migraine patients
High PRDM16 expression is associated with astrocytoma.
Our results suggest that K568 SUMOylation of sPRDM16 plays an important role in the progression of acute myeloid leukemia (zeige BCL11A Antikörper).
Results show that PRDM16 overexpression was highly recurrent in de novo paediatric AML (zeige RUNX1 Antikörper) and is associated with adverse outcome
PRDM16 might contribute to maintain adipose tissue "white fat" gene expression profile and systemic metabolic homeostasis.
PexRAP (zeige DHRS7B Antikörper) also interacts with PPARgamma (zeige PPARG Antikörper), as well as PRDM16, a critical transcriptional regulator of thermogenesis, and disrupts the PRDM16-PPARgamma (zeige PPARG Antikörper) complex, providing a potential mechanism for PexRAP (zeige DHRS7B Antikörper)-mediated inhibition of adipocyte browning.
Consecutive breeding to Flpe and Emx1 (zeige EMX1 Antikörper)(IREScre) deleter mice spatially restricted Prdm16 loss to regions of the forebrain expressing the homeobox (zeige PRRX1 Antikörper) gene Emx1 (zeige EMX1 Antikörper).
Prdm16 is required for adult neural stem cell maintenance and neurogenesis as well as the formation of ependymal cells
A single subtype of ganglion cell appears to be uniquely marked by Prdm16 expression. While the precise identity of these ganglion cells is unclear, they most resemble the G9 subtype described by Volgyi and colleagues in 2009.
Gelidium elegans stimulates the expression of PRDM16 and UCP-1 (zeige UCP1 Antikörper) Protein in brown adipose tissue and suppresses hyperglycemia in high-fat diet mice.
Both gain- and loss-of-function studies showed that an accumulation of the CCAAT/enhancer binding protein-beta (C/EBP-beta (zeige CEBPB Antikörper)) protein, which cooperates with dominant transcriptional co-regulator PR domain containing 16 (PRDM16) to determine brown/beige (zeige LYST Antikörper) adipocyte lineage, is essential for the enhanced adipocyte browning caused by the loss of ZIP13 (zeige SLC39A13 Antikörper)
Prdm16 plays an important role in dynamic cellular redox changes in developing neocortex during neural differentiation.
Together, these data indicate that PRDM16 diminishes responsiveness to type I interferon (zeige IFNA Antikörper) in adipose cells to promote thermogenic and mitochondrial function.
the cellular levels of alpha-ketoglutarate (alphaKG), a key metabolite required for TET-mediated DNA demethylation, were profoundly increased and required for active DNA demethylation of the Prdm16 promoter.
The reciprocal translocation t(1\;3)(p36\;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
PR domain containing 16
, PR domain zinc finger protein 16-like
, MDS1/EVI1-like gene 1
, PR domain zinc finger protein 16
, transcription factor MEL1
, PR domain-containing protein 16
, line 27