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The findings of the present study may aid in the clarification of the function of miR18a, particularly as regards its role in the regulation of Osteosarcoma (OS)cell apoptosis, and indicate that MED27 may be a potential novel therapeutic target in the treatment of OS.
MED27 promotes melanoma growth by targeting AKT/MAPK and NF-kappaB/iNOS signaling pathways.
Ubiquitous expression of crsp34 mRNA may suggest a universal requirement for Crsp34 in transcriptional initiation.
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5.
CRSP complex subunit 8
, cofactor required for Sp1 transcriptional activation, subunit 8, 34kDa
, mediator of RNA polymerase II transcription subunit 27
, p37 TRAP/SMCC/PC2 subunit
, transcriptional coactivator CRSP34
, mediator complex subunit 27
, cofactor required for Sp1 transcriptional activation subunit 8
, cofactor required for Sp1 transcriptional activation, subunit 8
, transcriptional co-activator CRSP8 homolog
, Mediator of RNA polymerase II transcription subunit 27
, CRSP complex subunit 8-B
, Cofactor required for Sp1 transcriptional activation subunit 8-B
, Mediator complex subunit 27-B
, cofactor required for Sp1 transcriptional activation subunit 8-B
, mediator complex subunit 27-B
, mediator of RNA polymerase II transcription subunit 27-B