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SPTLC1 Produkte

(serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1))
Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

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Ausgewählte SPTLC1 Kategorien

SPTLC1 Antikörper

High quality antibodies with extensive validation data.

SPTLC1 ELISA Kits

Reliable ELISA kits for a wide range of species.

SPTLC1 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene SPTLC1 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human, Mouse, Rat
Applikation WB, ELISA, IHC (p)
Validierungen
  • (6)
Kat. Nr. ABIN3187765
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Mouse
Applikation WB, IHC, IP, ICC
Validierungen
  • (4)
Kat. Nr. ABIN7436414
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, ELISA, IHC
Validierungen
  • (3)
Kat. Nr. ABIN7168895
Menge 100 μL
Datenblatt Datenblatt

Empfohlene SPTLC1 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6970110
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Mouse
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6959376
Menge 96 tests
Datenblatt Datenblatt

Empfohlene SPTLC1 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1321282
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN3095705
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Mouse
Source Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN3131666
Menge 1 mg
Datenblatt Datenblatt

Neueste Publikationen zu unseren SPTLC1 Produkten

Klas, Copic, Direder, Laggner, Prucksamas, Gruber, Ankersmit, Mildner: "Transcriptional Differences in Lipid-Metabolizing Enzymes in Murine Sebocytes Derived from Sebaceous Glands of the Skin and Preputial Glands." in: International journal of molecular sciences, Vol. 22, Issue 21, (2021) (PubMed).

Gupta, Gable, Alexaki, Chandris, Proia, Dunn, Harmon: "Expression of the ORMDLS, modulators of serine palmitoyltransferase, is regulated by sphingolipids in mammalian cells." in: The Journal of biological chemistry, Vol. 290, Issue 1, pp. 90-8, (2015) (PubMed).

Wei, Yerokun, Leipelt, Haynes, Radhakrishna, Momin, Kelly, Park, Wang, Carton, Uhlinger, Merrill: "Serine palmitoyltransferase subunit 1 is present in the endoplasmic reticulum, nucleus and focal adhesions, and functions in cell morphology." in: Biochimica et biophysica acta, Vol. 1791, Issue 8, pp. 746-56, (2009) (PubMed).

Medler, Petrusca, Lee, Hubbard, Berdyshev, Skirball, Kamocki, Schuchman, Tuder, Petrache: "Apoptotic sphingolipid signaling by ceramides in lung endothelial cells." in: American journal of respiratory cell and molecular biology, Vol. 38, Issue 6, pp. 639-46, (2008) (PubMed).

Stachowitz, Alessandrini, Abeck, Ring, Behrendt: "Permeability barrier disruption increases the level of serine palmitoyltransferase in human epidermis." in: The Journal of investigative dermatology, Vol. 119, Issue 5, pp. 1048-52, (2002) (PubMed).

Dawkins, Hulme, Brahmbhatt, Auer-Grumbach, Nicholson: "Mutations in SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary sensory neuropathy type I." in: Nature genetics, Vol. 27, Issue 3, pp. 309-12, (2001) (PubMed).

He, Appel, Le: "Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum." in: Brain research, Vol. 909, Issue 1-2, pp. 187-93, (2001) (PubMed).

Hanada, Hara, Nishijima, Kuge, Dickson, Nagiec: "A mammalian homolog of the yeast LCB1 encodes a component of serine palmitoyltransferase, the enzyme catalyzing the first step in sphingolipid synthesis." in: The Journal of biological chemistry, Vol. 272, Issue 51, pp. 32108-14, (1998) (PubMed).

Weiss, Stoffel: "Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis." in: European journal of biochemistry / FEBS, Vol. 249, Issue 1, pp. 239-47, (1997) (PubMed).

Synonyme und alternative Namen zu SPTLC1

serine palmitoyltransferase 1 (SPT1), serine palmitoyltransferase 1 (AFUA_6G00300), Serine palmitoyltransferase 1 (PAS_FragB_0040), serine palmitoyltransferase long chain base subunit 1 (SPTLC1), serine palmitoyltransferase, long chain base subunit 1 (sptlc1), serine palmitoyltransferase, long chain base subunit 1 L homeolog (sptlc1.L), serine palmitoyltransferase, long chain base subunit 1 (Sptlc1), serine palmitoyltransferase long chain base subunit 1 (Sptlc1), Afu6g00300, ATSPT1, AW552086, C77762, E030036H05, HSAN1, HSN1, LBC1, LCB1, Lcb1, RGD1306617, SERINE PALMITOYLTRANSFERASE 1, serine palmitoyltransferase 1, SPT1, Spt1, SPTI, wu:fc75h04, wu:fp41c08, zgc:112247

Bezeichner auf Proteinebene für SPTLC1

  • Serine palmitoyltransferase 1
  • LCB 1
  • SPT 1
  • long chain base biosynthesis protein 1
  • serine C-palmitoyltransferase
  • serine palmitoyltransferase 1
  • serine-palmitoyl-CoA transferase 1
  • fc75h04
  • fp41c08
  • SPT1
  • serine palmitoyltransferase subunit 1
  • Long chain base biosynthesis protein 1
  • Serine-palmitoyl-CoA transferase 1
  • serine palmitoyltransferase LCB1 subunit
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