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Development of a monoclonal anti-ADAMTS-5 (zeige ADAMTS5 Proteine) antibody that specifically blocks the interaction with LRP1.
MMP-13 (zeige MMP13 Proteine) may play a role on physiological turnover of cartilage extracellular matrix and that LRP1 is a key modulator of extracellular levels of MMP-13 (zeige MMP13 Proteine) and its internalization is independent of the levels of ADAMTS-4 (zeige ADAMTS4 Proteine), -5 and TIMP-3 (zeige TIMP3 Proteine).
Dissecting the interaction between TIMP3 (zeige TIMP3 Proteine) and LRP1 using a synthetic analog of the LRP1 receptor has been reported.
FVIIa-antithrombin (zeige SERPINC1 Proteine) but not FVIIa is a ligand for LRP1, and LRP1 contributes to the clearance of FVIIa-antithrombin (zeige SERPINC1 Proteine) in vivo
Activated alpha2 -Macroglobulin (zeige A2M Proteine) Induces Mesenchymal Cellular Migration Of Raw264.7 Cells Through Low-Density Lipoprotein Receptor-Related Protein 1
Study demonstrated that LRP1 expression is significantly upregulated by myeloid cells in active multiple sclerosis lesions in comparison to the surrounding healthy tissue. Results suggest that the function of LRP1 in microglia is to keep these cells in an anti-inflammatory and neuroprotective status during inflammatory insult.
Poor LRP1 expression in T cells depends on shedding. Integrin ligands and CXCL12 (zeige CXCL12 Proteine) antagonize shedding through a TSP-1 (zeige THBS1 Proteine)-dependent pathway and ligation of CD28 (zeige CD28 Proteine) antagonizes shedding independent of TSP-1 (zeige THBS1 Proteine).
Altered Met receptor phosphorylation and LRP1-mediated uptake in cells lacking carbohydrate-dependent lysosomal targeting
LRP1 single-nucleotide polymorphism is associated with migraine.
Electrostatic potential calculations suggested a competition between negatively charged GAGs and highly negatively charged complement-like domains of LRP-1 for the binding to a positively charged area of TIMP-3 (zeige TIMP3 Proteine) as an underlying mechanism.
Results suggest that LRP1 facilitates NSPCs differentiation via interaction with apolipoprotein E (ApoE (zeige APOE Proteine)). Upon ApoE4 stimulation wild type neural stem/progenitor cells generated more oligodendrocytes, but LRP1 knockout cells showed no response. The effect of ApoE (zeige APOE Proteine) seems to be independent of cholesterol uptake, but is rather mediated by downstream MAPK (zeige MAPK1 Proteine) and Akt (zeige AKT1 Proteine) activation.
Data suggest that Lrp1 shedding from microglia of cerebral cortex may amplify and sustain neuroinflammation in response to proinflammatory stimuli.
both LRP1 and LDLR (zeige LDLR Proteine) expression and agLDL uptake are regulated by P2Y2R (zeige P2RY2 Proteine) in vascular smooth muscle cells, and agLDL uptake due to P2Y2R (zeige P2RY2 Proteine) activation is dependent upon cytoskeletal reorganization mediated by P2Y2R (zeige P2RY2 Proteine) binding to FLN-A (zeige FLNA Proteine)
In experimental autoimmune encephalomyelitis mice lacking LRP1 in microglia or in macrophages, only microglial LRP1 was protective, as animals lacking LRP1 in this compartment experienced a worse clinical outcome. Results suggest that the function of LRP1 in microglia is to keep these cells in an anti-inflammatory and neuroprotective status during inflammatory insult, including experimental autoimmune encephalomyelitis.
Therefore, we concluded that the beneficial effects of LF might be due to an increase of autophagy activity via AMPK (zeige PRKAA1 Proteine) signaling through the LRP1 receptor. These findings provide a novel insight into the physiological role of LF for the maintenance of cellular and tissue homeostasis.
This study demonstrated that LRP1 suppresses microglial activation by modulating JNK (zeige MAPK8 Proteine) and NF-kappaB (zeige NFKB1 Proteine) signaling pathways. Down-regulation of LRP1 levels and the increased pro-inflammatory signaling may result in a vicious cycle, in which the two events synergistically promote microglial activation
ApoC-III (zeige APOC3 Proteine) inhibits turnover of TG-rich lipoproteins primarily through a hepatic clearance mechanism mediated by the LDLR (zeige LDLR Proteine)/LRP1 axis
These results provide evidence supporting a key role for the p38 MAPK (zeige MAPK14 Proteine) signaling pathway which is involved in the regulation of Abeta1-42 internalization in the parietal cortex and hippocampus of mouse through LRP1 in vivo.
BMPER (zeige BMPER Proteine)/low-density lipoprotein receptor-related protein 1 axis plays a pivotal role in pulmonary inflammatory response.
Even though LRP-1 mRNA and protein levels were dramatically reduced in LRP-1-silenced L6 cells compared with mock-silenced controls, rpIGFPB-3 suppressed proliferation rate to the same extent in both LRP-1-silenced and mock-silenced cultures.
Hypoxia increases LRP1 expression and that LRP1 overexpression mediates hypoxia-induced very low density lipoprotein-cholesteryl ester uptake and accumulation in cardiomyocytes.
Endometrial LRP1 protein expression was specifically high in such cyclic and pregnancy stages.
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.
, TbetaR-V/LRP-1/IGFBP-3 receptor
, alpha-2-macroglobulin receptor
, apolipoprotein E receptor
, prolow-density lipoprotein receptor-related protein 1
, type V tgf-beta receptor
, low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)
, low density lipoprotein receptor-related protein 1
, prolow-density lipoprotein receptor-related protein 1-like
, alpha 2-macroglobulin receptor
, lipoprotein receptor-related protein
, low-density lipoprotein receptor-related protein 1
, low-density lipoprotein receptor-related protein/alpha-2 macroglobulin receptor
, LOW QUALITY PROTEIN: prolow-density lipoprotein receptor-related protein 1