SMURF2 Produkte
(SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2))
Kategorien
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level (By similarity).
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Ausgewählte SMURF2 Kategorien
SMURF2 Antikörper
High quality antibodies with extensive validation data.
SMURF2 ELISA Kits
Reliable ELISA kits for a wide range of species.
SMURF2 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene SMURF2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro)
Validierungen
- (1)
- (4)
Kat. Nr.
ABIN753178
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Rat
Applikation
WB, IF, IHC (p)
Validierungen
- (1)
- (4)
Kat. Nr.
ABIN388831
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IF, IP
Validierungen
- (4)
Kat. Nr.
ABIN7101462
Menge
20 μL
Datenblatt
Datenblatt
Empfohlene SMURF2 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6970246
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6959517
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Validierungen
Kat. Nr.
ABIN1131328
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene SMURF2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
- (1)
Kat. Nr.
ABIN3095583
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Tobacco (Nicotiana tabacum)
Validierungen
- (1)
Kat. Nr.
ABIN3130681
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN5711831
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren SMURF2 Produkten
: "TRAF4 positively regulates the osteogenic differentiation of mesenchymal stem cells by acting as an E3 ubiquitin ligase to degrade Smurf2." in: Cell death and differentiation, (2019) (PubMed).: "Human trabecular meshwork cells express BMP antagonist mRNAs and proteins." in: Experimental eye research, Vol. 147, pp. 156-60, (2016) (PubMed).
: "The proteasome inhibitor, MG132, attenuates diabetic nephropathy by inhibiting SnoN degradation in vivo and in vitro." in: BioMed research international, Vol. 2014, pp. 684765, (2015) (PubMed).
: "Glucocorticoid-induced leucine zipper (GILZ) antagonizes TNF-? inhibition of mesenchymal stem cell osteogenic differentiation." in: PLoS ONE, Vol. 7, Issue 3, pp. e31717, (2012) (PubMed).
: "TRB3 interacts with SMAD3 promoting tumor cell migration and invasion." in: Journal of cell science, Vol. 124, Issue Pt 19, pp. 3235-46, (2011) (PubMed).
: "The E3 ubiquitin ligase SMAD ubiquitination regulatory factor 2 negatively regulates Krüppel-like factor 5 protein." in: The Journal of biological chemistry, Vol. 286, Issue 46, pp. 40354-64, (2011) (PubMed).
: "The interaction of mPar3 with the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity." in: The Journal of biological chemistry, Vol. 282, Issue 48, pp. 35259-68, (2007) (PubMed).
: "Ubiquitination of the GTPase Rap1B by the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity." in: The EMBO journal, Vol. 26, Issue 5, pp. 1410-22, (2007) (PubMed).
: "Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 3, pp. 974-9, (2001) (PubMed).
: "Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation." in: Molecular cell, Vol. 6, Issue 6, pp. 1365-75, (2001) (PubMed).
Synonyme und alternative Namen zu SMURF2
SMAD specific E3 ubiquitin protein ligase 2 (SMURF2), SMAD specific E3 ubiquitin protein ligase 2 (smurf2), SMAD specific E3 ubiquitin protein ligase 2 (Smurf2), SMAD specific E3 ubiquitin protein ligase 2 S homeolog (smurf2.S), 2810411E22Rik, AI558114, AI649275, RGD1310067, SMURF2, wu:fb82a11, wu:fc41c02Bezeichner auf Proteinebene für SMURF2
- SMAD specific E3 ubiquitin protein ligase 2
- E3 ubiquitin-protein ligase SMURF2-like
- e3 ubiquitin-protein ligase SMURF2-like
- E3 ubiquitin ligase SMURF2
- E3 ubiquitin-protein ligase SMURF2
- SMAD ubiquitination regulatory factor 2
- SMAD-specific E3 ubiquitin-protein ligase 2
- hSMURF2
- E3 ubiquitin ligase Smurf2
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