anti-COL4A1 (COL4A1) Antikörper

Zebrafish Collagen, Type IV, alpha 1 (COL4A1) Interaktionspartner

1. the shiomaneki (sio) gene locus encodes Col4a6 (zeige COL4a6 Antikörper), a subunit of type IV collagen (zeige COL4 Antikörper), which, in a complex with Col4a5, is a basement membrane (BM) component. Both col4a5 and col4a6 (zeige COL4a6 Antikörper) mutants displayed similar abnormalities in the axogenesis

2. During motor axon regeneration, col4a5 destabilizes axons probing inappropriate trajectories to ensure target-selective regeneration, possible through slit1a.

3. Genetic and biochemical studies indicate that Slit binds to Dragnet (Col4a5) which forms the basement membrane on the surface of the tectum.

Human Collagen, Type IV, alpha 1 (COL4A1) Interaktionspartner

1. this study shows that COL4A1 production by urothelial carcinoma of the bladder plays a pivotal role in tumor invasion through the induction of tumor budding

2. Strong correlations between the expression of type I, II, IV collagen and osteopontin (zeige SPP1 Antikörper) and the clinical stage of tympanosclerosis indicate the involvement of these proteins in excessive fibrosis and pathological remodeling of the tympanic membrane.

3. Genotype-phenotype correlations in pathology caused by COL4A1 and COL4A2 (zeige COL4a2 Antikörper) mutations have been summarized. (Review)

4. Urine levels of COL4A1, COL13A1 (zeige COL13A1 Antikörper), the combined values of COL4A1 and COL13A1 (zeige COL13A1 Antikörper) (COL4A1 + COL13A1 (zeige COL13A1 Antikörper)), and CYFRA21-1 were significantly elevated in urine from patients with BCa (zeige BLNK Antikörper) compared to the controls. A high urinary COL4A1 + COL13A1 (zeige COL13A1 Antikörper) was found to be an independent risk factor for intravesical recurrence.

5. Building collagen IV (zeige COL4 Antikörper) smart scaffolds on the outside of cells has been summarized. (Review)

6. Our findings extend the spectrum of COL4A1 mutations linked with renal disease and demonstrate that the highly conserved C-terminal part of the NC1 domain of the alpha1 chain of type IV collagen (zeige COL4 Antikörper) is important in the integrity of glomerular basement membrane in humans.

7. Twist1 (zeige TWIST1 Antikörper) appears to require both palladin (zeige PALLD Antikörper) and collagen alpha1(VI) as downstream effectors for its prometastatic effects, which could be future therapeutic targets in cancer metastasis.

8. only collagen-IV (zeige COL4 Antikörper) elicits the formation of proteolytically active podosomes through a mechanism involving increased Src (zeige SRC Antikörper) phosphorylation, p190RhoGAP (zeige GRLF1 Antikörper)-B (also known as ARHGAP5 (zeige ARHGAP5 Antikörper)) relocalisation and MT1-MMP (zeige MMP14 Antikörper) (also known as MMP14 (zeige MMP14 Antikörper)) cell surface exposure at podosome sites.

9. Mutations upregulating COL4A1 expression lead topontine autosomal dominant microangiopathy with leukoencephalopathy (PADMAL).

10. The study shows an association of the COL4A1 gene with cerebral palsy and suggests a potential role of COL4A1 in the pathogenesis of this disease.

Mouse (Murine) Collagen, Type IV, alpha 1 (COL4A1) Interaktionspartner

1. Col4a1 mutation generates vascular abnormalities correlated with neuronal damage in a mouse model of HANAC syndrome

2. Embryo implantation triggers dynamic spatiotemporal expression of the basement membrane toolkit (Col4a1, GPBP (zeige COL4A3BP Antikörper), Lamc1 (zeige LAMC1 Antikörper), peroxidasin) during uterine reprogramming.

3. DDR1 (zeige DDR1 Antikörper) kinase activity is required for regulating collagen IV (zeige COL4 Antikörper) synthesis.

4. the lens and possibly vasculature play important roles in Col4a1-related anterior segment dysgenesis.

5. Mutations in murine Col4a1 and Col4a2 (zeige COL4a2 Antikörper) genes affected the balance between lung epithelial progenitors and differentiated cells. Mutations in Col4a1 derived from the vascular component were sufficient to cause defects in vascular development and the blood-gas barrier. Col4a1 and Col4a2 (zeige COL4a2 Antikörper) mutants displayed disrupted myofibroblast proliferation, differentiation and migration.

6. This extensive description of the muscular phenotype of the Col4a1 HANAC murine model suggests a potential contribution of primary endothelial cell defects, together with muscle BM alterations, to the development of COL4A1-related myopathy.

7. The findings indicate the critical role of CatB in regulating the expression of collagens III and IV by fibroblasts via prolonging TLR2/NF-kappaB (zeige NFKB1 Antikörper) activation and oxidative stress.

8. data show that both basement membrane defects and ER stress contribute to Col4a1 renal disease, which has important implications for the development of treatment strategies for collagenopathies

9. Silencing the Col4-alpha1 gene or disrupting integrin engagement by blocking the antibody reduced the expression of platelet-derived growth factor A (PDGF-A (zeige PDGFA Antikörper)), a potent chemotactic factor for fibroblasts.

10. Col4a1 mutations cause abnormal vascular development, which triggers small-vessel disease, recurrent hemorrhagic strokes, and age-related macroangiopathy.

Cow (Bovine) Collagen, Type IV, alpha 1 (COL4A1) Interaktionspartner

1. High shear stress up-regulates type IV collagen (zeige COL4 Antikörper) synthesis and down-regulates MMP-2 (zeige MMP2 Antikörper) secretion in endothelial cells.

2. alpha1.alpha2 stabilize the noncollagenous domain-1 by noncovalent forces and the absence of Met-Lys (zeige LYZ Antikörper) cross-links