anti-SH2 Domain Protein 2A (SH2D2A) Antikörper

Human SH2 Domain Protein 2A (SH2D2A) Interaktionspartner

1. Data indicate that the T cell-specific adaptor protein (TSAd) SH2 domain interacts with CD6 antigen (zeige CD6 Antikörper) and linker for activation of T cells (zeige LAT Antikörper) protein (LAT (zeige ORC3 Antikörper)) phosphotyrosine (pTyr) peptides.

2. TSAD binds to and co-localizes with Nck (zeige NCK1 Antikörper). Expression of TSAD increases both Nck (zeige NCK1 Antikörper)-Lck (zeige LCK Antikörper) and Nck (zeige NCK1 Antikörper)-SLP-76 (zeige LCP2 Antikörper) interaction in T cells.

3. The kinase Itk (zeige ITK Antikörper) and the adaptor TSAd change the specificity of the kinase Lck (zeige LCK Antikörper) in T cells by promoting the phosphorylation of Tyr192.

4. Data indicate the expression pattern of T cell-specific adapter protein (TSAd) in various healthy lymphoid and non-lymphoid tissues.

5. in chronic inflammatory demyelinating polyneuropathy we found an association with a homozygous genotype for a low repeat number of tandem GA in the SH2D2A gene

6. TSAd, through its interaction with both Itk and Lck, primes Itk for Lck mediated phosphorylation and thereby regulates CXCL12 induced T cell migration and actin cytoskeleton rearrangements

7. TSAd associates with laminin binding protein (zeige RPSA Antikörper) and mediates T lymphocyte migration during T cell activation

8. TSAd appears to contribute to interleukin-2 (zeige IL2 Antikörper) synthesis at multiple different levels

9. upon chemokine (zeige CCL1 Antikörper) stimulation, Lad (zeige DLD Antikörper) acts as an adaptor protein that links the G protein beta subunit (zeige GNB3 Antikörper) to the tyrosine kinases Lck (zeige LCK Antikörper) and Zap-70 (zeige ZAP70 Antikörper), thereby mediating T-cell migration

10. SH2D2A expression is regulated both at the transcriptional and translational level.

Mouse (Murine) SH2 Domain Protein 2A (SH2D2A) Interaktionspartner

1. These results revealed that vascular sprouting and permeability are both controlled through the VEGFR2-TSAd-c-Src signaling pathway in a subset of tissues, which may be useful in developing strategies to control tissue-specific pathological angiogenesis.

2. Sh2d2a protein deficient mice display reduced clearance of Dm157 MCMV infection in the spleen.

3. The kinase Itk (zeige ITK Antikörper) and the adaptor TSAd change the specificity of the kinase Lck (zeige LCK Antikörper) in T cells by promoting the phosphorylation of Tyr192.

4. Results suggest a modulatory role for T cell specific adapter protein SH2D2A in T cell mediated immune surveillance of cancer.

5. Data show that tyrosine phosphorylation of VEGF receptor 2 (VEGFR2) facilitates binding of VEGFR2 (zeige KDR Antikörper) to the Rous sarcoma (Src (zeige SRC Antikörper)) homology 2-domain of T cell-specific adaptor (TSAd), which in turn regulates VEGF (zeige VEGFA Antikörper)-induced activation of the c-Src tyrosine kinase (zeige CSK Antikörper).

6. results show that TSAd, particularly the SH2 (zeige MYO15 Antikörper) domain of TSAd, is essential for the effector functions of T cells.

7. TSAd, through its interaction with both Itk and Lck, primes Itk for Lck mediated phosphorylation and thereby regulates CXCL12 induced T cell migration and actin cytoskeleton rearrangements

8. role of TSAd as a critical regulator of T cell death whose absence promotes systemic autoimmunity

9. TSAd appears to contribute to interleukin-2 (zeige IL2 Antikörper) synthesis at multiple different levels

10. The major role of T cell-specific adapter protein in peripheral T cell cytoplasm is for activation of LCK (zeige LCK Antikörper) protein tyrosine kinase (zeige YES1 Antikörper) at the outset of T cell receptor signal transduction