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Human Polyclonal PCNT Primary Antibody für ICC, IF - ABIN253210
Basten, Willekers, Vermaat, Slaats, Voest, van Diest, Giles: Reduced cilia frequencies in human renal cell carcinomas versus neighboring parenchymal tissue. in Cilia 2013
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Human Polyclonal PCNT Primary Antibody für ICC, IF - ABIN4344848
Pasdeloup, Labetoulle, Rixon: Differing effects of herpes simplex virus 1 and pseudorabies virus infections on centrosomal function. in Journal of virology 2013
Show all 2 Pubmed References
The partial loss of these structures may largely explain the complex centriole, centrosome and cilium defects we observe in Plp mutant cells.
Cnn and PLP directly interact at two defined sites to coordinate the cell cycle-dependent rearrangement and scaffolding activity of the centrosome to permit normal centrosome organization, cell division, and embryonic viability.
Basal body formation in the male testes and the production of functional sperm does not rely on the PLP-CaM interaction, whereas production of functional mechanosensory neurons does.
Data indicate that interphase centrioles are closely associated with Sas-4, Spd-2, Polo kinase (zeige PLK1 Antikörper), Pericentrin-like protein (Dplp), Asterless (zeige CEP152 Antikörper) (Asl (zeige ADSL Antikörper)), Plk4 (zeige PLK4 Antikörper) kinase, Centrosomin (zeige EIF3A Antikörper) (Cnn) and gamma-tubulin (zeige TUBG1 Antikörper).
identification of CP309 which can bind to calmodulin; it is is required for microtubule nucleation mediated by centrosomes and it interacts with the gamma-tubulin (zeige TUBG1 Antikörper) small complex
we identified two novel mutations in the PCNT gene associated with Microcephalic osteodysplastic primordial dwarfism type II and intracranial aneurysms
PCNT has to be phosphorylated by PLK1 (zeige PLK1 Antikörper) to be a suitable substrate of separase (zeige ESPL1 Antikörper).
Cep68 degradation allows Cep215 (zeige CDK5RAP2 Antikörper) removal from peripheral pericentriolar material (PCM (zeige PCMT1 Antikörper)) preventing centriole separation following disengagement, PCNT cleavage mediates Cep215 (zeige CDK5RAP2 Antikörper) removal from core of the PCM (zeige PCMT1 Antikörper) to inhibit centriole disengagement and duplication
The CEP215 (zeige CDK5RAP2 Antikörper)-pericentrin interaction is required for centrosome maturation and subsequent bipolar spindle formation during mitosis.
Data suggest that changes in the expression levels of PCNT in DS subjects may be involved into the molecular mechanism of Down's syndrome.
PCNT gene mutation is associated with hematological abnormalities in patients with microcephalic osteodysplastic primordial dwarfism type II.
Che-1 (zeige BCHE Antikörper) depletion abolishes the ability of Chk1 (zeige CHEK1 Antikörper) to bind pericentrin and to localize at centrosomes, which, in its turn, deregulates the activation of centrosomal cyclin B-Cdk1 (zeige CDK1 Antikörper) and advances entry into mitosis.
The pericentrin B cleavage is essential for timely centriole disengagement and duplication.
Kendrin is a novel and crucial substrate for separase (zeige ESPL1 Antikörper) at the centrosome, protecting the engaged centrioles from premature disengagement and thereby blocking reduplication until the cell passes through mitosis.
Expression of RRP1B, PCNT, KIF21A (zeige KIF21A Antikörper) and ADRB2 (zeige ADRB2 Antikörper) in leucocytes of Down's syndrome subjects, was analyzed.
experiments demonstrate a role for Pericentrin in modulating Piezo2 (zeige FAM38B Antikörper) activity and membrane expression in somatosensory neurons
Meiotic division is highly error-prone in the absence of Pcnt and disrupted acentriolar microtubule-organizing centers.
Pericentrin is a key functional component of the unique acentriolar MTOCs of mouse oocytes, and plays an important role in regulating meiotic spindle assembly and/or stability.
The mouse Pcnt(-/-) phenotype was associated with misdirected ventricular septal growth in the heart, decreased proliferative symmetric divisions in brain neural progenitors, and increased misoriented divisions in fibroblasts.
Findings suggest distinct functional roles of several Pcnt variants in different ciliated tissues and sensory neurons, like the olfactory epithelium and the retina of the mouse
A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice
results confirm that MT1-MMP (zeige MMP14 Antikörper) cleaves pericentrin-2 in humans but not in mice and that mouse models of cancer probably cannot be used to critically examine MT1-MMP (zeige MMP14 Antikörper) functionality
Pcnt was shown to be localized to the base of primary cilia in multiple embryonic tissues, in agreement with a recent study demonstrating the involvement of Pcnt in primary cilia formation using cultured mammalian cells.
Pericentrin forms complexes with CHD3 (zeige CHD3 Antikörper) and CHD4 (zeige CHD4 Antikörper), but a distinct CHD3 (zeige CHD3 Antikörper)-pericentrin complex is required for centrosomal anchoring of pericentrin/gamma-tubulin (zeige TUBG1 Antikörper) and for centrosome integrity.
pPKCdelta(Thr505) interacts with MTOC-associated proteins pericentrin and gamma-tubulin (zeige TUBG1 Antikörper), and plays a role in meiotic spindle organization in oocytes
The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II.
, drosophila pericentrin like protein
, lethal (3) s2172
, pericentrin-like protein
, pericentrin/AKAP450 centrosomal targeting
, pericentrin B
, DIP2 disco-interacting protein 2 homolog A
, pericentrin (kendrin)
, pericentrin 2 (kendrin)
, pericentrin 2