anti-GABRA5 (GABRA5) Antikörper

Rhesus Monkey gamma-aminobutyric Acid (GABA) A Receptor, alpha 5 (GABRA5) Interaktionspartner

1. GABRA5 receptor plays a unique role in reinforcing the effects of alcohol.

2. evaluated the role of alpha1 and alpha5 subunit-containing GABAA (zeige GABRg1 Antikörper) receptors (alpha1GABAA and alpha5GABAA receptors, respectively) in the ability of benzodiazepine-type drugs to alter performance in the cognitive domain of executive function

Human gamma-aminobutyric Acid (GABA) A Receptor, alpha 5 (GABRA5) Interaktionspartner

1. Report benzodiazepine derivative as GABA-site inhibitor of extra-synaptic GABAA (zeige GABRg1 Antikörper) alpha5 receptors.

2. Study found that a significant portion of GABAergic postsynaptic compartments contain the alpha5 GABAAR (zeige GABRG2 Antikörper) subunit, both in vitro and in vivo

3. This study showed that in male groups, the expression of GABRA5 was generally lower in schizophrenia cases compared to the control.

4. Findings provide genetic evidence for the involvement of the genes GABRB3 (zeige GABRB3 Antikörper) and GABRA5 in the susceptibility to panic disorder

5. 1,2-dichlorohexafluorocyclobutane enhancement of GABRA5 activity is abolished by GABRB3 (zeige GABRB3 Antikörper) mutations.

6. These results provide initial evidence of a GABAA (zeige GABRg1 Antikörper) alpha5 deficit in autism spectrum disorder and support further investigations of the GABA system in this disorder.

7. The ratios of beta(3)/beta(2) and alpha(5)/alpha(1) subunit protein expression in Angelman syndrome (zeige ube3a Antikörper) cortex were significantly decreased when compared with controls.

8. These results suggest that the GABRA5 gene may confer susceptibility to bipolar I disorder.

Mouse (Murine) gamma-aminobutyric Acid (GABA) A Receptor, alpha 5 (GABRA5) Interaktionspartner

1. findings support the hypothesis that reduced alpha5GABAAR activity contributes to an Autism Spectrum Disorder phenotype. The results also suggest that Gabra5-/- mice may serve as an animal model for ASD (zeige GUSB Antikörper), as assessed through EEG activity and sleep-wake behaviors.

2. Deletion of Gabra5 in newborn granule cells caused severe alterations of migration and dendrite development.

3. Report benzodiazepine derivative as GABA-site inhibitor of extra-synaptic GABAA (zeige GABRg1 Antikörper) alpha5 receptors.

4. This study demonstrated that alpha5-GABAAR (zeige GABRG2 Antikörper)-mediated tonic inhibition in the DG plays an important role in ensuring normal cognitive functioning under high-interference memory conditions.

5. The results of this study suggested that gabra5 mediated tonic current, which is potentiated by H2O2, might contribute to H2O2-induced brain dysfunction.

6. in mice that lack the alpha5 subunit gene (Gabra5-/-), cultured embryonic hippocampal pyramidal neurons and ex vivo CA1 (zeige CA1 Antikörper) hippocampal neurons unexpectedly exhibited a decrease in Ih current density

7. Gabra5-gene haplotype block associated with behavioral properties of the full agonist benzodiazepine chlordiazepoxide.

8. Data suggest that chronic exposure to ketamine impairs working memory in mice, which may be explained at least partly by up-regulation of Gabra5 subunits in the prefrontal cortex.