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anti-Mouse (Murine) EYA1 Antikörper:
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Human Polyclonal EYA1 Primary Antibody für ELISA, WB - ABIN560818
El-Hashash, Al Alam, Turcatel, Bellusci, Warburton: Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. in Developmental biology 2011
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Cow (Bovine) Polyclonal EYA1 Primary Antibody für WB - ABIN2778550
Suzuki, Fujisawa, Ando, Niino, Ohsawa, Shimokata, Ohta: Alcohol dehydrogenase 2 variant is associated with cerebral infarction and lacunae. in Neurology 2004
Show all 2 Pubmed References
Human Polyclonal EYA1 Primary Antibody für ELISA, WB - ABIN4309808
Orten, Fischer, Sorensen, Radhakrishna, Cremers, Marres, Van Camp, Welch, Smith, Kimberling: Branchio-oto-renal syndrome (BOR): novel mutations in the EYA1 gene, and a review of the mutational genetics of BOR. in Human mutation 2008
Notch (zeige NOTCH1 Antikörper) is regulated by the threonine phosphatase activity of Eya1. Eya1 dephosphorylates p-threonine-2122 of the Notch1 (zeige NOTCH1 Antikörper) intracellular domain (Notch1 (zeige NOTCH1 Antikörper) ICD), which increases the stability of Notch1 (zeige NOTCH1 Antikörper) ICD and maintains Notch (zeige NOTCH1 Antikörper) signaling activity in the non-neuronal epibranchial placodal cells.
Eya1 phosphatase promotes Shh (zeige SHH Antikörper) signaling during hindbrain development and oncogenesis
results reveal a functional link between Eya1, Six2 (zeige SIX2 Antikörper), and Myc (zeige MYC Antikörper) in driving the expansion and maintenance of the multipotent progenitors during nephrogenesis
BOR syndrome-associated Eya1 missense mutations S454P, L472R, and L550P lead to enhanced proteasomal degradation of the Eya1 protein.
these findings reveal that the canonical Wnt (zeige WNT2 Antikörper) and PI3K/Akt (zeige AKT1 Antikörper) signal pathways restrain the GSK3/Fbw7 (zeige FBXW7 Antikörper)-dependent Eya1 ubiquitination, and they further suggest that dysregulation of this novel axis contributes to tumorigenesis.
The EYA1 phosphatase regulates cell-cycle control via transcriptional complex formation at the cyclin D1 (zeige CCND1 Antikörper) promoter.
These findings uncover novel functions for Six1 (zeige SIX1 Antikörper)-Eya1-SHH (zeige SHH Antikörper) pathway during the saccular phase of lung morphogenesis.
EYA1 is efficiently degraded during mitotic exit in a ANAPC1 (zeige ANAPC1 Antikörper)-dependent manner and these two proteins physically interact.
EYA1 and SIX1 (zeige SIX1 Antikörper) drive the neuronal developmental program in cooperation with the SWI (zeige SMARCA1 Antikörper)/SNF (zeige SNRPA Antikörper) chromatin-remodeling complex and SOX2 (zeige SOX2 Antikörper) in the mammalian inner ear.
Deletion of either or both Six1 (zeige SIX1 Antikörper) and Eya1 genes results in genitourinary tract defects including persistent cloaca; hypospadias; and hypoplastic genitalia.
Data report the identification of the related proteins Sipl1 (Shank-interacting protein-like 1 (zeige SHARPIN Antikörper)) and Rbck1 (RBCC protein interacting with PKC1 (zeige RBCK1 Antikörper)) as novel interaction partners of Eya1.
First report of an essential role of Eya1, which is required for lineage-specific differentiation of adenohypophyseal cells, but not for their survival.
Six1 (zeige SIX1 Antikörper) and Eya1 can both promote and arrest neuronal differentiation by activating the Notch (zeige NOTCH1 Antikörper) pathway genes.
These studies lend support to the hypothesis that dominant-negative effects of EYA1 mutations may have a role in the pathogenesis of branchio-oto (zeige PGAP1 Antikörper)-renal syndrome.
Eya1 and Six1 (zeige SIX1 Antikörper) are required for both the regulation of placodal neuronal progenitor proliferation, through their effects on SoxB1 expression, and subsequent neuronal differentiation.
These results identify the conserved arginine residues of EYA1 that play an important role for its activity, thus implicating arginine methylation as a novel regulatory mechanism of EYA function.
A variety of DNA changes including large deletions underlie BOR syndrome in different populations, which can be detected with comprehensive genetic testing
Results found that EYA1 affects FBW7 (zeige FBXW7 Antikörper)-Myc (zeige MYC Antikörper) binding to regulate the FBW7 (zeige FBXW7 Antikörper)-mediated Myc (zeige MYC Antikörper) degradation machinery in breast cancer cells.
miR (zeige MLXIP Antikörper)-101 is downregulated in breast cancer, and can inhibit cell proliferation and promote apoptosis by targeting EYA1 through the Notch (zeige NOTCH1 Antikörper) signaling pathway.
Association between EYA1 three SNPs and NSOCs and suggested that maternal environmental tobacco smoke, common cold history, and alcohol consumption.
Our findings implicate this EYA1 partial duplication segregating with branchiootic phenotype in a Brazilian pedigree and is the first description of a large duplication leading to the Branchiootorenal syndrome/BO syndrom
Three causative genes for BOR syndrome have been reported thus far: EYA1, SIX1 (zeige SIX1 Antikörper), and SIX5, but the causative genes for approximately half of all BOR patients remain unknown.[review]
we proved that the branchiooto (BO) syndrome in these cases was caused by germinal mosaicism of the EYA1 gene in either the mother or father.
PI3K (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper) signaling enhances Eya1 transcription activity, which largely attributes to the phosphorylation-induced reduction of Eya1 SUMOylation.
Low EYA1 expression is associated with gastric carcinoma.
This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may play a role in the developing kidney, branchial arches, eye, and ear. Mutations of this gene have been associated with branchiootorenal dysplasia syndrome, branchiootic syndrome, and sporadic cases of congenital cataracts and ocular anterior segment anomalies. A similar protein in mice can act as a transcriptional activator. Four transcript variants encoding three distinct isoforms have been identified for this gene.
eyes absent 1
, eyes absent homolog 1 (Drosophila)
, eyes absent homolog 1
, eyes absent-1
, dog eared
, eyes absent-1 beta
, eyes absent 1 homolog