Maus anti-Human IgD (full length), (Heavy Chain) Antikörper

Produktnummer ABIN7879401

Kurzübersicht für Maus anti-Human IgD (full length), (Heavy Chain) Antikörper (ABIN7879401)

Target: IgD

Klonalität: Monoklonal

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: IGHD-4967

Isotyp: IgG2a, kappa

Produktdetails

Bindungsspezifität: full length, Heavy Chain

Reaktivität: Human

Wirt: Maus

Verwendungszweck: IgD Heavy Chain Antibody (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: Full-length human IGHD protein was used as the immunogen for the IgD Heavy Chain antibody.

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the IgD Heavy Chain antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the IgD Heavy Chain antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Antigendetails

Target: IgD

Substanzklasse: Antibody

Hintergrund: Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through interchain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin D (IgD) exists as a monomer with delta heavy chains and either kappa or lambda light chains. It plays a biological role as a transmembrane receptor molecule, co-expressed with IgM on the surface of mature/naive B cells. In particular, it is found on spleen B cell surfaces. Compared to IgM, IgD exists in much lower numbers and is not expressed on immature B cells. IgD surface expression on B cells is regulated in part by IL-27. In mice, the inhibition of this immunoglobulin isotype does not cause a significant change to the immune system.

UniProt: P01880