SAV1 Produkte
(Salvador Homolog 1 (SAV1))
Kategorien
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. [provided by RefSeq, Aug 2012].
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Ausgewählte SAV1 Kategorien
SAV1 Antikörper
High quality antibodies with extensive validation data.
SAV1 ELISA Kits
Reliable ELISA kits for a wide range of species.
SAV1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene SAV1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IF, IP
Validierungen
- (6)
- (6)
Kat. Nr.
ABIN566210
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC, IF, IP
Validierungen
- (5)
Kat. Nr.
ABIN7166096
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC, IF
Validierungen
- (5)
Kat. Nr.
ABIN7166095
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene SAV1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Validierungen
Kat. Nr.
ABIN1152411
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Validierungen
Kat. Nr.
ABIN1152412
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Validierungen
Kat. Nr.
ABIN1152413
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene SAV1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Mouse
Source
HEK-293 Cells
Validierungen
- (3)
Kat. Nr.
ABIN7564754
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (3)
Kat. Nr.
ABIN7555334
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Cell-free protein synthesis (CFPS)
Validierungen
Kat. Nr.
ABIN3136732
Menge
0.5 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren SAV1 Produkten
: "Hippo pathway deficiency reverses systolic heart failure after infarction." in: Nature, Vol. 550, Issue 7675, pp. 260-264, (2018) (PubMed).: "Kidney-specific knockout of Sav1 in the mouse promotes hyperproliferation of renal tubular epithelium through suppression of the Hippo pathway." in: The Journal of pathology, Vol. 239, Issue 1, pp. 97-108, (2016) (PubMed).
: "Hippo signaling mediates proliferation, invasiveness, and metastatic potential of clear cell renal cell carcinoma." in: Translational oncology, Vol. 7, Issue 2, pp. 309-21, (2014) (PubMed).
: "Actin-binding and cell proliferation activities of angiomotin family members are regulated by Hippo pathway-mediated phosphorylation." in: The Journal of biological chemistry, Vol. 288, Issue 52, pp. 37296-307, (2013) (PubMed).
: "Mammalian ste20-like kinase and SAV1 promote 3T3-L1 adipocyte differentiation by activation of PPAR?." in: PLoS ONE, Vol. 7, Issue 1, pp. e30983, (2012) (PubMed).
: "Screening of binding proteins that interact with human Salvador 1 in a human fetal liver cDNA library by the yeast two-hybrid system." in: Molecular biology reports, Vol. 39, Issue 8, pp. 8225-30, (2012) (PubMed).
: "LATS2 is a tumor suppressor gene of malignant mesothelioma." in: Cancer research, Vol. 71, Issue 3, pp. 873-83, (2011) (PubMed).
: "Salvador protein is a tumor suppressor effector of RASSF1A with hippo pathway-independent functions." in: The Journal of biological chemistry, Vol. 286, Issue 21, pp. 18483-91, (2011) (PubMed).
: "Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction." in: Nature cell biology, Vol. 12, Issue 12, pp. 1166-76, (2010) (PubMed).
: "Mutational analysis of salvador gene in human carcinomas." in: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 111, Issue 6, pp. 595-8, (2003) (PubMed).
Synonyme und alternative Namen zu SAV1
salvador family WW domain containing protein 1 (SAV1), salvador family WW domain containing 1 (Sav1), salvador family WW domain containing protein 1 (Sav1), 1700040G09Rik, Salv, SAV, Sav, WW45, Wwp3, WWP4, Wwp4Bezeichner auf Proteinebene für SAV1
- 1700040G09Rik
- 45 kDa WW domain protein
- WW domain-containing
- hWW45
- protein salvador homolog 1
- WW domain-containing protein 3
- WW domain-containing protein 4
- Salvador homolog 1 protein
- rWW45
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