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anti-Human SHC1 Antikörper:
anti-Rat (Rattus) SHC1 Antikörper:
anti-Mouse (Murine) SHC1 Antikörper:
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Mouse (Murine) Polyclonal SHC1 Primary Antibody für WB - ABIN1881805
Trnka, Burlingame et al.: Topographic studies of the GroEL-GroES chaperonin complex by chemical cross-linking using diformyl ethynylbenzene: the power of high resolution electron transfer dissociation for determination of... in Molecular & cellular proteomics : MCP 2010
Show all 5 Pubmed References
Human Polyclonal SHC1 Primary Antibody für WB - ABIN2801945
Migliaccio, Mele, Salcini, Pelicci, Lai, Superti-Furga, Pawson, Di Fiore, Lanfrancone, Pelicci: Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway. in The EMBO journal 1997
Show all 3 Pubmed References
Human Monoclonal SHC1 Primary Antibody für IF, IHC - ABIN2731989
Bhat, Baba, Adams, Khanday: Role of SNTA1 in Rac1 activation, modulation of ROS generation, and migratory potential of human breast cancer cells. in British journal of cancer 2014
Characterization of bioenergetic parameters and reactive oxygen species production showed that the cellular model of Leigh syndrome is described by increased intracellular oxidative stress and oxidative damage to DNA and proteins, which correlate with increased p66Shc phosphorylation at Ser36.
A positive relationship between the p66Shc expression and oxidative stress was found. p66Shc and oxidative stress were significant predictors of the degree of tubular damage.
Adeno (zeige ADORA2A Antikörper)-X Adenoviral System 3 can be used to efficiently construct recombinant adenovirus containing p66Shc gene, and the Adeno (zeige ADORA2A Antikörper)-X can inhibit the proliferation of MCF-7 cells by inducing cell cycle arrest at the G2/M phase
STAT4 (zeige STAT4 Antikörper) is a novel transcriptional regulator of p66Shc in normal and chronic lymphocytic leukemia B cells
Isoform b of DDR1 (zeige DDR1 Antikörper) is responsible for collagen I-induced up-regulation of N-cadherin (zeige CDH2 Antikörper) and tyrosine 513 of DDR1b is necessary.
NIC (zeige NCSTN Antikörper) exacerbated AZA-dependent injury via augmenting p66shc transcription. While RES suppressed NIC (zeige NCSTN Antikörper)+AZA-mediated injury, -surprisingly-it further enhanced activity of the p66shc promoter. RES protected cells via the cytoplasmic p66shc/Nrf2 (zeige GABPA Antikörper)/heme oxygenase-1 (HO-1 (zeige HMOX1 Antikörper)) axis
The results show that the interaction between STS-1 (zeige STS1 Antikörper) and ShcA is regulated in response to EGF receptor (zeige EGFR Antikörper) activation.
Nox4 (zeige NOX4 Antikörper)-derived H2O2 in part activates Nox2 (zeige CYBB Antikörper) to increase mitochondrial ROS (zeige ROS1 Antikörper) via pSer36-p66Shc, thereby enhancing VEGFR2 (zeige KDR Antikörper) signaling and angiogenesis in endothelial cells.
Taken together, these data argue for a complex mechanism of PKC-beta-dependent regulation of SH (zeige POLD3 Antikörper)CA (p66) activation invol (zeige SIGLEC1 Antikörper)ving Ser(139) and a motif surroun (zeige SIGLEC1 Antikörper)ding Ser(213).
Data identify, for the first time, a novel non-canonical dynamic mode of interaction between Met and the p66 (zeige POLD3 Antikörper) protein isoform of Shc and its effects on rewiring binding effector complexes according to the activation state of the receptor.
Data show that adaptor protein Shc is required for angiogenesis in zebrafish (accession number LOC563639), mice, and human vascular endothelial cell-culture models.
ShcA is required for Wnt-5a (zeige WNT5A Antikörper)/Ror2 (zeige ROR2 Antikörper) mediated upregulation of xPAPC (zeige PCDH8 Antikörper), which demonstrates the functional relevance of this interaction.
Studied p66Shc levels, redox state, and developmental potential in early bovine embryos. p66Shc content was increased by either high (20%) O(2) culture or H(2)O(2) treatment, and significantly dec'd by antioxidant polyethylene glycol-conjugated catalase (zeige CAT Antikörper).
p66shc, but not p53 (zeige TP53 Antikörper), is significantly more abundant in an embryo population that exhibits higher frequencies of embryo arrest.
p66Shc is involved in the regulation of embryo development specifically in mediating early cleavage arrest and facilitating development to the blastocyst stage for in vitro produced bovine embryos
These results support a model in which Shc orchestrates signals from cell-cell and cell-matrix adhesions to elicit flow-induced inflammatory signaling.
Data show that 66-kDa Src (zeige SRC Antikörper) homology 2 domain-containing protein (p66Shc) is acetylated under high glucose conditions and is deacetylated by Sirtuin1 (zeige SIRT1 Antikörper) lysine deacetylase (Sirt1 (zeige SIRT1 Antikörper)) on lysine 81.
P66Shc, a key regulator of metabolism and mitochondrial ROS (zeige ROS1 Antikörper) production, is dysregulated by mouse embryo culture
The results indicate that Shc proteins should be considered as potential targets for developing interventions to mitigate weight gain on high-fat diet by stimulating energy expenditure.
Hyperglycemia and elevated free fatty acids in the diabetic milieu recruit p66Shc to upregulate endothelial miR (zeige MLXIP Antikörper)-34a via an oxidant-sensitive mechanism, which leads to endothelial dysfunction by targeting Sirt1 (zeige SIRT1 Antikörper).
p66SHC-mediated oxidative stress and telomere shortening synergize in some tissues (including testes) to accelerate aging.
Taken together, these data argue for a complex mechanism of PKCbeta-dependent regulation of p66 (zeige POLD3 Antikörper) activation involving Ser (zeige SIGLEC1 Antikörper)(139) and a motif surrounding Ser (zeige SIGLEC1 Antikörper)(213).
JNK1 (zeige MAPK8 Antikörper)/2-dependent regulation of p66ShcS36 phosphorylation, is reported.
Data show that the major mitochondrial partner of Shc adaptor protein p46Shc is the lipid oxidation enzyme 3-ketoacylCoA thiolase (zeige HADHB Antikörper) ACAA2 (zeige ACAA2 Antikörper), to which p46Shc binds directly and with a strong affinity.
In mice and humans, reduced p66Shc levels protect from obesity, but not from ectopic fat accumulation, glucose intolerance and insulin (zeige INS Antikörper) resistance.
p53 (zeige TP53 Antikörper)-dependent augmentation of p66(Shc) expression and function represents a key signalling response contributing to beta cell apoptosis under conditions of lipotoxicity
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.
SHC (Src homology 2 domain containing) transforming protein 1
, Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores; has similarity to Skt5p, which activates Chs3p during vegetative growth; transcriptionally induced at alkaline pH
, squalene--hopene cyclase
, SH2 domain protein C1
, SHC-transforming protein 1
, src homology 2 domain-containing-transforming protein C1
, SHC-transforming protein 1-like
, SHC (Src homology 2 domain-containing) transforming protein 1
, SHC-transforming protein 3
, SHC-transforming protein A
, src homology 2 domain-containing transforming protein C1
, src homology collagen
, adaptor protein SHC