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genetic variants in BICC1 and RASGRF1 are closely associated with high myopia, which appears to be a potential candidate for high myopia in Chinese Han population.
Endoplasmic reticulum stress triggers a localized signaling module on the ER surface involving Nox4-dependent calcium mobilization, which directs local Ras activation through ER-associated, calcium-responsive RasGRF.
Data show that microRNA miR (zeige MLXIP Proteine)-137 directly recognized the 3'-UTR (3'-untranslated region) of the RASGRF1 (Ras protein-specific guanine nucleotide-releasing factor 1) transcript and regulated RASGRF1 expression.
Impaired RASGRF1/ERK (zeige EPHB2 Proteine)-mediated GM-CSF (zeige CSF2 Proteine) response characterizes CARD9 (zeige CARD9 Proteine) deficiency in French-Canadians.
Carriers of the rs8027411 G allele in the RASGRF1 gene may be at a lower risk of high myopia in Chinese and Japanese populations. (Meta-analysis)
Rasgrf-1 is a novel GEF (zeige SLC2A4RG Proteine) protein that has a role in BCR (zeige BCR Proteine) signaling and its overexpression further activates the Ras/Erk/MAPK (zeige MAPK1 Proteine) pathway in CLL specimens.
In this study, there was no association of the analyzed SNPs located in RASGRF1. GJD2 (zeige GJD2 Proteine), and ACTC1 (zeige ACTC1 Proteine) with pathological myopia.
CARD9 (zeige CARD9 Proteine) regulates H-Ras (zeige HRAS Proteine) activation by linking Ras-GRF1 to H-Ras (zeige HRAS Proteine), which mediates Dectin-1 (zeige CLEC7A Proteine)-induced extracellular signal-regulated protein kinase (zeige CDK7 Proteine) (ERK (zeige EPHB2 Proteine)) activation and proinflammatory responses when stimulated by their ligands.
ZIC2 (zeige ZIC2 Proteine) and RASGRF1 are susceptibility genes, not only for common myopia, but also for high myopia.
Decreased expression of Ras-GRF1 could be involved in the pathogenesis of human temporal lobe epilepsy.
Novel mercaptoacetamide-based class II histone deacetylase (zeige HDAC1 Proteine) inhibitor HDACIW2 treatment regulated the levels of RasGRF1 and p-ERK (zeige EPHB2 Proteine), and that W2 requires RasGRF1 and ERK (zeige EPHB2 Proteine) signaling to alter dendritic spine formation, suggesting that W2 regulates dendritic spine formation via a RasGRF1/ERK (zeige EPHB2 Proteine)-dependent signaling pathway
Data (including data from studies in knockout mice) suggest mechanisms involving RasGRF1 exist to regulate hypothalamic-pituitary-adrenal axis in early-adolescent females; such mechanisms appear absent in younger/older female or adolescent male mice.
VLDLR (zeige VLDLR Proteine) requires RasGRF1/CaMKII (zeige CAMK2G Proteine) to alter dendritic spine formation.
Study suggests a complex role of ERK (zeige EPHB2 Proteine)-dependent and Ras-GRF1-dependent signaling in corticostriatal plasticity, highlights differences between synaptic mechanisms in naive slices and dopamine-depleted preparations from L-DOPA-treated dyskinetic animals
RasGrf1 is an important upstream component of signal transduction pathways regulating Pttg1 (zeige PTTG1 Proteine) expression and controlling beta cell development and physiological responses.
GRF1 is expressed in new neurons when GRF1 loss begins to effect neuronal function, promoting late stages of adult neurogenesis. GRF1 is an age-dependent regulator of adult hippocampal neurogenesis and the ability to distinguish closely related contexts.
Data indicate that contextual discrimination involves term potentiation (LTP (zeige SCP2 Proteine)) promoted by calcium-permeable AMPA (zeige GRIA3 Proteine)-type glutamate (zeige GRIN1 Proteine) receptors, RAS-GRF1 and p38 MAP kinase (zeige MAPK14 Proteine).
Ras-GRF1 and -GRF2 (zeige RASGRF2 Proteine) may act as adaptors that bind PLCgamma1 (zeige PLCG1 Proteine) and restrict Ca2 (zeige CA2 Proteine)+ signalling to the vicinity of focal adhesions, indicating a new role for these GRFs that is required for IL-1 (zeige IL1A Proteine) induction of the Ras-->ERK (zeige EPHB2 Proteine) pathway and MMP-3 (zeige MMP3 Proteine) expression
identified the guanine nucleotide exchange factor Rasgrf1 as a direct Zac1/Plagl1 (zeige PLAGL1 Proteine) target gene in beta cells
In conclusion, our results indicated that the Rasgrf1 gene shows both species- and tissue-specific variation in imprinted expression.
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Ras-specific guanine nucleotide-releasing factor, CDC25 homolog
, Ras-specific nucleotide exchange factor CDC25
, guanine nucleotide exchange factor
, guanine nucleotide-releasing factor 1
, guanine nucleotide-releasing factor, 55 kD
, guanine nucleotide-releasing protein
, ras-specific guanine nucleotide-releasing factor 1
, GRF beta
, Ras guanine release factor beta
, guanine nucleotide releasing factor 1
, ras-specific nucleotide exchange factor CDC25
, P140 RAS-GRF
, Ras protein-specific guanine nucleotide-releasing factor 1
, ras-specific guanine nucleotide-releasing factor 1-like