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Low RASGRF1 expression due to hypermethylation is associated with Colorectal Cancer.
Our studies have shown that the heritability of myopia makes 66.4% in Lithuania. We detected significant associations between the combinations of GJD2 CC and RASGRF1 GT and odds ratio of developing myopia.
genetic variants in BICC1 and RASGRF1 are closely associated with high myopia, which appears to be a potential candidate for high myopia in Chinese Han population.
Endoplasmic reticulum stress triggers a localized signaling module on the ER surface involving Nox4-dependent calcium mobilization, which directs local Ras activation through ER-associated, calcium-responsive RasGRF.
Data show that microRNA miR-137 directly recognized the 3'-UTR (3'-untranslated region) of the RASGRF1 (Ras protein-specific guanine nucleotide-releasing factor 1) transcript and regulated RASGRF1 expression.
Impaired RASGRF1/ERK-mediated GM-CSF response characterizes CARD9 deficiency in French-Canadians.
Carriers of the rs8027411 G allele in the RASGRF1 gene may be at a lower risk of high myopia in Chinese and Japanese populations. (Meta-analysis)
Rasgrf-1 is a novel GEF protein that has a role in BCR signaling and its overexpression further activates the Ras/Erk/MAPK pathway in CLL specimens.
In this study, there was no association of the analyzed SNPs located in RASGRF1. GJD2, and ACTC1 with pathological myopia.
CARD9 regulates H-Ras activation by linking Ras-GRF1 to H-Ras, which mediates Dectin-1-induced extracellular signal-regulated protein kinase (ERK) activation and proinflammatory responses when stimulated by their ligands.
ZIC2 and RASGRF1 are susceptibility genes, not only for common myopia, but also for high myopia.
Decreased expression of Ras-GRF1 could be involved in the pathogenesis of human temporal lobe epilepsy.
Aberrant methylation of RASGRF1 is associated with an epigenetic field defect and increased risk of gastric cancer.
RasGRF1 plays an important role in alveolar rhabdomyosarcoma pathogenesis
Demonstrate a role for RasGRF1/2 as negative regulators of Cdc42 activation, suppressing tumor cell movement, cytoskeletal dynamics and cell transformation.
Single Nucleotide Polymorphisms in RASGRF1 is associated with refractive errors and myopia.
Farnesylated or geranylgeranylated TC21 can be activated by RasGRF1 due to its pleckstrin homology 1 domain, by a mechanism independent of localization & of its ability to associate to membranes.
RasGRF family exchange factors, both endogenous and ectopically expressed, are present in the endoplasmic reticulum but not in the Golgi complex
Taken together our results demonstrate that U2AF35a is essential for HeLa cell division and suggest a novel role for both U2AF35 protein isoforms as regulators of alternative splicing of a specific subset of genes.
Vitamin K3 inhibitor H32 differentially inhibited growth of normal and liver tumor cells by preferentially inhibiting the actions of Cdc25 phosphatases
The deletion of RasGRF1 attenuated myocardial fibrosis and improved cardiac function in diabetic mice through inhibiting inflammation and oxidative stress.
hypermethylation of RASgrf1 after kainate induced status epilepticus could be reversed with corresponding changes of RASgrf1 expression
These findings demonstrate that RASgrf1 is closely associated with epilepsy via the aberrant methylation of RASgrf1, and regulating the methylation status of relevant genes might be an intriguing topic in future research on epilepsy.
Novel mercaptoacetamide-based class II histone deacetylase inhibitor HDACIW2 treatment regulated the levels of RasGRF1 and p-ERK, and that W2 requires RasGRF1 and ERK signaling to alter dendritic spine formation, suggesting that W2 regulates dendritic spine formation via a RasGRF1/ERK-dependent signaling pathway
Data (including data from studies in knockout mice) suggest mechanisms involving RasGRF1 exist to regulate hypothalamic-pituitary-adrenal axis in early-adolescent females; such mechanisms appear absent in younger/older female or adolescent male mice.
VLDLR requires RasGRF1/CaMKII to alter dendritic spine formation.
Study suggests a complex role of ERK-dependent and Ras-GRF1-dependent signaling in corticostriatal plasticity, highlights differences between synaptic mechanisms in naive slices and dopamine-depleted preparations from L-DOPA-treated dyskinetic animals
RasGrf1 is an important upstream component of signal transduction pathways regulating Pttg1 expression and controlling beta cell development and physiological responses.
GRF1 is expressed in new neurons when GRF1 loss begins to effect neuronal function, promoting late stages of adult neurogenesis. GRF1 is an age-dependent regulator of adult hippocampal neurogenesis and the ability to distinguish closely related contexts.
Data indicate that contextual discrimination involves term potentiation (LTP) promoted by calcium-permeable AMPA-type glutamate receptors, RAS-GRF1 and p38 MAP kinase.
Ras-GRF1 and -GRF2 may act as adaptors that bind PLCgamma1 and restrict Ca2+ signalling to the vicinity of focal adhesions, indicating a new role for these GRFs that is required for IL-1 induction of the Ras-->ERK pathway and MMP-3 expression
identified the guanine nucleotide exchange factor Rasgrf1 as a direct Zac1/Plagl1 target gene in beta cells
Present RasGRF1-derived peptides displaying both in vitro and in vivo Ras inhibitory properties.
p190A is required in both the epithelial and stromal compartments for ductal outgrowth and it may play a role in mammary epithelial cell differentiation
these results indicate that Rasgrf1 expression from the wild-type paternal allele contributes to learning and memory in neonatal mice.
role of RASGRF1 in aging, lifespan and metabolic parameters were analyzed in aged RasGrf1(-/-) mice. We observed that mice deficient for RasGrf1(-/-) display an increase in average and most importantly, in maximal lifespan (20% higher than controls).
study found components of the piRNA pathway are required for de novo methylation of the differentially methylated region of imprinted Rasgrf1 locus; propose a model in which piRNAs and a target RNA direct sequence-specific methylation of Rasgrf
These data reveal the central role of Ras-GRF1 in governing striatal adaptations to dopamine replacement therapy and validate a viable treatment for LID based on intracellular signaling modulation.
In conclusion, our results indicated that the Rasgrf1 gene shows both species- and tissue-specific variation in imprinted expression.
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Ras-specific guanine nucleotide-releasing factor, CDC25 homolog
, Ras-specific nucleotide exchange factor CDC25
, guanine nucleotide exchange factor
, guanine nucleotide-releasing factor 1
, guanine nucleotide-releasing factor, 55 kD
, guanine nucleotide-releasing protein
, ras-specific guanine nucleotide-releasing factor 1
, GRF beta
, Ras guanine release factor beta
, guanine nucleotide releasing factor 1
, ras-specific nucleotide exchange factor CDC25
, P140 RAS-GRF
, Ras protein-specific guanine nucleotide-releasing factor 1
, ras-specific guanine nucleotide-releasing factor 1-like