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A short-linear interaction motif between residues 337-343 of AKAP79 is the sole PP2B-anchoring determinant sustaining these diverse topologies.
Mutation in PPP3CA gene is associated with Severe Neurodevelopmental Disease with Seizures.
identify a distinct C-terminal autoinhibitory four-residue sequence in CNAbeta1, (462)LAVP(465), which competitively inhibits substrate dephosphorylation. In vitro and cell-based assays revealed that the CNAbeta1-containing holoenzyme, CNbeta1, is autoinhibited at a single site by either of two inhibitory regions, CBD (zeige OPN1MW Proteine) and LAVP, which block substrate access to the substrate-binding groove.
Studies indicate the importance of the AKAP79 (zeige AKAP5 Proteine)/PP2B/protein kinase A complex's role in synaptic long-term depression in the CA1 (zeige CA1 Proteine) region of the hippocampus.
Ca(2 (zeige CA2 Proteine)+)/calcineurin (CaN)/nuclear factor of activated T-cells (NFAT (zeige NFATC1 Proteine)) c4 axis is required for neuritin (zeige NRN1 Proteine)-induced Kv4.2 (zeige KCND2 Proteine) transcriptional expression and potentiation of IA densities in cerebellum granule neurons.
CN-A and nephrin were (zeige CABIN1 Proteine) clearly reduced in the kidneys of a 10-year-old boy who had relapsing steroid-resistant nephrotic syndrome (zeige NPHS1 Proteine).
that KIF1Bbeta affects mitochondrial dynamics through calcineurin-dependent dephosphorylation of Dynamin-related protein 1 (DRP1 (zeige DNM1L Proteine)), causing mitochondrial fission and apoptosis
for Aspergillus fumigatus, activation of macrophage calcineurin-NFAT (zeige NFATC1 Proteine) occurs via a phagosomal TLR9 (zeige TLR9 Proteine)-dependent and Bruton's tyrosine kinase (zeige BTK Proteine)-dependent signalling pathway that is independent of MyD88 (zeige MYD88 Proteine)
Data indicate that both nuclear factors of activated T cells (NFATs) motifs partially compete for binding but do not fully displace each other on the calcineurin (Cn) epitope.
Lysosomal calcium signaling regulates autophagy through calcineurin and TFEB (zeige TFEB Proteine).
calcineurin is a key regulator of Wnt5a (zeige WNT5A Proteine)-induced AQP2 (zeige AQP2 Proteine) activation without affecting intracellular cAMP level and PKA activity.
Redirected splicing of calcineurin A to the fetal isoforms in adult muscle and in differentiated C2C12 slows the timing of muscle relaxation, promotes nuclear localization of calcineurin target Nfatc3 (zeige NFATC3 Proteine), and/or affects expression of Nfatc (zeige NFATC1 Proteine) transcription targets.
these results demonstrate that increased susceptibility to Aspergillus fumigatus is dependent on calcineurin signaling in myeloid cells
the CaN-Nfat (zeige NFATC1 Proteine) pathway regulates development and function of IFN-gamma (zeige IFNG Proteine)-producing gammadelta T cells.
the expression of the full-length 60-kDa calcineurin protein is down-regulated due to over-activated calpain that cleaves calcineurin to form a 45-kDa fragment.
AKAP150-calcineurin signaling dyad is essential for the activation of the phosphatase and the subsequent down-regulation of Kv channel currents following myocardial infarction.
Calcineurin inhibitor (zeige RCAN1 Proteine) tacrolimus ameliorated proteinuria in nephrotic model by inhibiting the redistribution of CN-A and nephrin (zeige NPHS1 Proteine) at the slit diaphragm.
global deficiency of catalytic subunit Ppp3cb (zeige PPP3CB Proteine), and tissue-specific ablation of regulatory subunit Ppp3r1 (zeige PPP3R1 Proteine) from skeletal muscle, but not adipose tissue or liver, led to protection from high-fat-diet-induced obesity
Overexpression of the phosphatase calcineurin A prevents the development of a capillary/myocyte mismatch despite progressive myocardial hypertrophy.
The calmodulin binding region from residues 389 to 420 was modeled based on the structure of two other proteins having calmodulin binding domains with the same 1-8-14 structural motif as calcineurin.
The findings reveal a novel mechanism by which Ca2 (zeige CA2 Proteine)+ overload disrupts myofibril integrity by activating a Calcineurin-FoxO (zeige FOXO3 Proteine)-MuRF1 (zeige TRIM63 Proteine)-proteosome signaling pathway.
catalytic subunit of Calcineurin (CaN), ubiquitously expressed Ca2+/CaM-dependent protein phosphatase\; mediates activities of transcription factors and ion channels\; involved in regulation of T-cell activation
CAM-PRP catalytic subunit
, calcineurin A alpha
, calmodulin-dependent calcineurin A subunit alpha isoform
, protein phosphatase 2B, catalytic subunit, alpha isoform
, protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform
, serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
, PP2B alpha 1
, PP2BA alpha
, protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha)
, protein phosphatase 3, catalytic subunit, alpha isoform
, Calcineurin subunit A alpha
, protein phosphatase-2Ba
, calcineurin catalytic subunit delta isoform
, calcineurin catalytic subunit
, protein phosphatase 3, catalytic subunit, alpha isozyme
, serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like