PPP3CA Protein (AA 1-511) (His tag)

Produktnummer ABIN6386673

Produktdetails

Target: PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-511

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses PPP3CA Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Produktmerkmale: PPP3CA, 1-511aa, Human, His tag, E.coli

Reinheit: > 85 % by SDS - PAGE

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.2M NaCl, 5mM DTT, 1mM EDTA, 20% glycerol

Lagerung: 4 °C

Antigendetails

Target: PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA))

Andere Bezeichnung: PPP3CA (PPP3CA Produkte)

Synonyme: CALN Protein, CALNA Protein, CALNA1 Protein, CCN1 Protein, CNA1 Protein, PPP2B Protein, 2900074D19Rik Protein, AI841391 Protein, AW413465 Protein, CN Protein, Caln Protein, Calna Protein, CnA Protein, Calna1 Protein, calcineurin Protein, caln Protein, calna Protein, calna1 Protein, ccn1 Protein, cna1 Protein, ppp2b Protein, fj46e08 Protein, si:dkeyp-79c2.2 Protein, wu:fj46e08 Protein, ppp3ca Protein, protein phosphatase 3 catalytic subunit alpha Protein, protein phosphatase 3, catalytic subunit, alpha isoform Protein, protein phosphatase 3, catalytic subunit, alpha isozyme Protein, protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha) Protein, protein phosphatase 3, catalytic subunit, alpha isozyme L homeolog Protein, serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Protein, PPP3CA Protein, Ppp3ca Protein, ppp3ca Protein, ppp3ca.L Protein, LOC100205420 Protein

Hintergrund: PPP3CA, also known as Calcineurin A, is a major soluble calmodulin binding protein in the brain, a Ca2+/calmodulin dependent serine/threonine protein phosphatase, with a relatively narrow substrate specificity. It activates the T cells of the immune system and can be blocked by drugs. PPP3CA activates NFATc, a transcription factor by dephosphorylating it. The activated NFATc is then translocated into the nucleus, where it upregulates the expression of interleukin 2. Recombinant human PPP3CA protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Serine/threonine-protein phosphatase 2B catalytic subunit alpha, CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B. NCBI no.: NP_001124163

Molekulargewicht: 60.0 kDa (534aa)

Pathways: RTK Signalweg, WNT Signalweg, Fc-epsilon Rezeptor Signalübertragung, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Synaptic Membrane, Skeletal Muscle Fiber Development, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling