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Human Monoclonal PDGFRA Primary Antibody für FACS, IP - ABIN4900645
Velghe, Van Cauwenberghe, Polyansky, Chand, Montano-Almendras, Charni, Hallberg, Essaghir, Demoulin: PDGFRA alterations in cancer: characterization of a gain-of-function V536E transmembrane mutant as well as loss-of-function and passenger mutations. in Oncogene 2014
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Human Monoclonal PDGFRA Primary Antibody für FACS - ABIN4898823
Uosaki, Andersen, Shenje, Fernandez, Christiansen, Kwon: Direct contact with endoderm-like cells efficiently induces cardiac progenitors from mouse and human pluripotent stem cells. in PLoS ONE 2012
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Human Polyclonal PDGFRA Primary Antibody für WB - ABIN271391
Zheng, Ishii, Tokunaga, Hamashima, Shen, Zhao, Ishizawa, Fujimori, Nabeshima, Mori, Kondo, Sasahara: Neuroprotective effects of PDGF against oxidative stress and the signaling pathway involved. in Journal of neuroscience research 2010
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Mouse (Murine) Monoclonal PDGFRA Primary Antibody für FACS - ABIN1176995
Fruttiger, Calver, Krüger, Mudhar, Michalovich, Takakura, Nishikawa, Richardson: PDGF mediates a neuron-astrocyte interaction in the developing retina. in Neuron 1997
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Human Monoclonal PDGFRA Primary Antibody für FACS - ABIN4898820
Craft, Rockel, Nartiss, Kandel, Alman, Keller: Generation of articular chondrocytes from human pluripotent stem cells. in Nature biotechnology 2015
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Human Polyclonal PDGFRA Primary Antibody für ICC, IF - ABIN446762
Ataca, Soyturk, Karaman, Unlu, Sagol, Dervis Hakim, Yilmaz: Nilotinib-mediated mucosal healing in a rat model of colitis. in World journal of gastroenterology 2013
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Human Polyclonal PDGFRA Primary Antibody für PLA, WB - ABIN518742
Moroncini, Grieco, Nacci, Paolini, Tonnini, Pozniak, Cuccioloni, Mozzicafreddo, Svegliati, Angeletti, Kazlauskas, Avvedimento, Funaro, Gabrielli: Epitope Specificity Determines Pathogenicity and Detectability of Anti-Platelet-Derived Growth Factor Receptor α Autoantibodies in Systemic Sclerosis. in Arthritis & rheumatology (Hoboken, N.J.) 2015
Human Monoclonal PDGFRA Primary Antibody für PLA, ELISA - ABIN518743
Dugas, Cuellar, Scholze, Ason, Ibrahim, Emery, Zamanian, Foo, McManus, Barres: Dicer1 and miR-219 Are required for normal oligodendrocyte differentiation and myelination. in Neuron 2010
Human Polyclonal PDGFRA Primary Antibody für IF (p), IHC (p) - ABIN726620
Hu, Zeng, Jiang, Hu, Meng, Zhu, Mao: The expression of marker for endometrial stem cell and fibrosis was increased in intrauterine adhesious. in International journal of clinical and experimental pathology 2015
Human Monoclonal PDGFRA Primary Antibody für CyTOF, FACS - ABIN4344477
Vanarsdall, Wisner, Lei, Kazlauskas, Johnson: PDGF receptor-α does not promote HCMV entry into epithelial and endothelial cells but increased quantities stimulate entry by an abnormal pathway. in PLoS pathogens 2012
PDGFRA is not essential for the derivation and maintenance of extraembryonic endoderm stem (XEN) cell lines .
loss of Pdgfra in endothelial-derived (zeige MED28 Antikörper) mesenchyme in the outflow tract endocardial cushions leads to a secondary defect in neural crest migration during development.
Investigated the developmental process of mesenchymal stem cells (MSCs) in embryos using the gene Pdgfra as a marker. We traced cells expressing Pdgfra and other genes (brachyury (zeige TBX1 Antikörper), Sox1 (zeige SOX1 Antikörper) and Pmx1 (zeige PRRX1 Antikörper)) in various mutant embryos until the adult stage. Embryonic MSCs emerge in waves and almost all adult bone marrow MSCs and white adipose tissue MSCs originate from mesoderm and embryonic Pdgfralpha-positive cells.
PDGFRalpha/PDGFRbeta signaling balance determines progenitor commitment to beige (zeige LYST Antikörper) (PDGFRalpha) or white (PDGFRbeta) adipogenesis.
Spreading of PDGFR-alpha-deficient lung fibroblasts was insensitive to increased rigidity, and their migration was not reduced by Rac1-guanine exchange factor (GEF (zeige ARHGEF2 Antikörper))-inhibition. PDGFR-alpha-expressing fibroblasts migrated toward stiffer regions within two-dimensional substrates by increasing migrational persistence (durotaxis).
Histone H3.3K27M and Trp53 (zeige TP53 Antikörper) loss and PDGFRA overexpression accelerates disease onset and increases tumor invasion.
The diabetes-induced increase in PDGFRalpha+ cells may be mediated by FOXO3 up-regulation via the inhibition of the PI3K/Akt signaling pathway in STZ-induced diabetic mice.
Constitutive activation of PDGFRalpha leads to expansion of cartilage underlying the coronal sutures, which contribute to suture closure through endochondral ossification, in a process regulated in part by PI3K/AKT (zeige AKT1 Antikörper) signaling.
OLIG2 (zeige OLIG2 Antikörper) modulates growth factor signaling in two distinct populations of glioma stem cells, characterized by expression of either the epidermal growth factor receptor (EGFR (zeige EGFR Antikörper)) or platelet-derived growth factor receptor alpha.
Conditional knockout of Pdgfra in Pdgfra-expressing tissues in mouse embryos at different embryonic days (E9.5 and E10.5) resulted in multiple developmental anomalies of the frontonasal region, the cranium and the abdominal wall musculature. Furthermore, the day at which the Pdgfra is deleted influences the repertoire of the anomalies of the conditional knockout embryos.
High PDGFR (zeige PDGFRB Antikörper) expression is associated with retinal neovascularization.
None of the 16 analyzable tumors showed mutations in PDGFRA. Thus, PDGFRA mutations probably do not play an important role in the development of sporadic lipomas of the intestines
Whole transcriptome sequencing followed by pathway analysis indicated that STXBP4 (zeige STXBP4 Antikörper) is involved in functional gene networks that regulate cell growth, proliferation, cell death, and survival in cancer. Platelet-derived growth factor receptor alpha (PDGFRalpha) was a key downstream mediator of STXBP4 (zeige STXBP4 Antikörper) function. In line with this, shRNA mediated STXBP4 (zeige STXBP4 Antikörper) and PDGFRA knockdown suppressed tumor growth in soft-agar and xenograft ...
We report a unique case of an SDH (zeige SARDH Antikörper)-deficient GIST case with an activating PDGFRA mutation. Oncogenic mutations in GIST are generally mutually exclusive; however documented exceptions exist which may have diagnostic and therapeutic implications.
Case Report: concurrent development of myeloproliferative hypereosinophilic syndrome and lymphomatoid papulosis associated with FIP1L1 (zeige FIP1L1 Antikörper)-PDGFRA gene fusion.
Our results suggest that PDGFRalpha overexpression in HCC (zeige FAM126A Antikörper) is a prognostic marker independent of adjacent non-tumor site liver fibrosis status.
overview of primary cilia-mediated regulation of receptor tyrosine kinase (zeige RET Antikörper) (RTK- PDGFRa and PDGFRb (zeige PDGFRB Antikörper)) and transforming growth factor beta (TGF-beta) signaling [review]
PDGFRA mutation, but not amplification is associated with older age in pediatric high-grade glioma.
Study demonstrates for the first time that PDGFR-alpha strongly inhibits endothelial and melanoma cells proliferation in a CXCL10/IP-10 (zeige CXCL10 Antikörper) dependent way, via miR (zeige MLXIP Antikörper)-503 down-regulation.
PDGFRalpha activation is an essential component that drives aggressiveness in papillary thyroid carcinoma cells. The signaling pathways are complex, involving not only the MAPK/Erk (zeige MAPK1 Antikörper) but also the PI3K (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper) and STAT3 (zeige STAT3 Antikörper) pathways.
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.
platelet-derived growth factor receptor, alpha polypeptide
, alpha-type platelet-derived growth factor receptor-like
, Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha)
, CD140 antigen-like family member A
, PDGF alpha chain
, alpha-type platelet-derived growth factor receptor
, platelet-derived growth factor alpha receptor
, platelet-derived growth factor receptor alpha
, alpha platelet-derived growth factor receptor
, CD140a antigen
, PDGFRA/BCR fusion
, platelet-derived growth factor receptor 2
, rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein
, tyrosine kinase PDGFR