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Human PDGFB Protein expressed in Escherichia coli (E. coli) - ABIN1589629
Rezzola, Dal Monte, Belleri, Bugatti, Chiodelli, Corsini, Cammalleri, Cancarini, Morbidelli, Oreste, Bagnoli, Semeraro, Presta: Therapeutic Potential of Anti-Angiogenic Multitarget N,O-Sulfated E. Coli K5 Polysaccharide in Diabetic Retinopathy. in Diabetes 2015
Mouse (Murine) PDGFB Protein expressed in Escherichia coli (E. coli) - ABIN413709
Hamada, Gonda, Takeda, Sato, Watanabe, Yambe, Satomi, Ohuchi: In vivo imaging of the molecular distribution of the VEGF receptor during angiogenesis in a mouse model of ischemia. in Blood 2011
Human PDGFB Protein expressed in Escherichia coli (E. coli) - ABIN413706
Tsuchida, Schneider, Pizani, Oliveira: Lead and aluminum bonding in Pb-AI metaphosphate glasses. in Inorganic chemistry 2008
Human PDGFB Protein expressed in Escherichia coli (E. coli) - ABIN804609
Huang, Zhao, Fields, Ransohoff, Zhou: Imatinib attenuates skeletal muscle dystrophy in mdx mice. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009
we identified two potential susceptibility loci for PC risk, which are located in PDGFB at 22q13.1
Treating HepG2 cells with hepatotoxicants resulted in a significant increase in mRNA expression of platelet-derived growth factor BB (PDGF (zeige PDGFA Proteine)-BB) and transforming growth factor beta (TGFbeta (zeige TGFB1 Proteine)).
The morphology and immunophenotype of all 6 cases was analogous to those with the canonical COL1A1 (zeige COL1A1 Proteine)-PDGFB fusion; none of the cases showed fibrosarcomatous transformation. This study illustrates that the COL6A3 (zeige COL6a3 Proteine)-PDGFD (zeige PDGFD Proteine) fusion product is rare in dermatofibrosarcoma protuberans, and associated with an apparent predilection for breast
PDGF-B expression was found in ovarian tumor microvessels in 72% of cases. High expression of PDGF (zeige PDGFA Proteine) in pericapillary cells was strongly associated with high expression of this marker in cancer cells. Significant correlations between PDGF-B and nestin (zeige NES Proteine) expression in malignant tumor microvessels were also found.
SOX7 transcription factor (zeige SOX7 Proteine) mediates PDGF (zeige PDGFA Proteine)-BB-induced IL-33 (zeige IL33 Proteine) expression.
High expression of PDGF (zeige PDGFA Proteine)-BB may be involved in the pathogenesis of Graves' disease. CCR2 (zeige CCR2 Proteine)-positive macrophages may induce the expression of PDGF (zeige PDGFA Proteine)-BB through HIF-1alpha (zeige HIF1A Proteine) signal.
rhPDGF-BB promoted the proliferation of hADSCs via miR (zeige MLXIP Proteine)-363/PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) pathway, indicating that rhPDGF-BB combined with ADSCs could treat Achilles tendinitis via miR (zeige MLXIP Proteine)-363/PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) pathway.
This review showed that PDGFB was one of the common gene involved included with brain calcification.
Rare Skin Tumor Dermatofibrosarcoma Protuberans (DFSP) is characterized by the translocation of the PDGFB gene to the collagen 1A1 (zeige COL1A1 Proteine) gene.
Transglutaminase type 2 affects cell migration through post-translational modification of PDGF (zeige PDGFA Proteine)-BB.
intrinsic PDGF-B expressed in the spinal cord may play an essential role in neuroregulation in primates following cord hemisection
hypoxia increased the expression of platelet-derived growth factor (PDGF (zeige PDGFA Proteine)) and transforming growth factor-beta1 (TGF-beta1 (zeige TGFB1 Proteine)) and decreased the expression of neprilysin (NEP (zeige MME Proteine)), which contributed to the hypoxia-induced Endothelial-to-mesenchymal transition of pulmonary artery endothelial cells.
Study suggest that PDGF-B is induced by hypoxia and protects against apoptosis via the PI3K/Akt (zeige AKT1 Proteine)/Stat3 (zeige STAT3 Proteine) signaling pathway.
PDGF-B transcription is increased by Nuclear Factor Kappa B
up-regulated by Angiotensin II in retinal pericytes; results suggest that Ang II (zeige AGT Proteine)-type 1 receptor interaction could stimulate PDGF-B gene expression in cultured retinal pericytes through intracellular reactive oxygen species generation
PEDF promotes growth of pericytes through autocrine production of PDGFB.
Hypoxia enhances PDGF-B paracrine interactions between glomerular endothelial and mesangial cells.
microRNA let-7g suppresses PDGF (zeige PDGFA Proteine)-induced conversion of vascular smooth muscle cell into the atherosclerotic phenotype.
The PDGFB-overexpressing murine tumors closely cluster with human proneural and mesenchymal subtypes, as well as PDGFRA (zeige PDGFRA Proteine)-amplified at both the RNA and protein expression levels. These models can be generated in fully immunocompetent mixed or C57BL/6 genetic background mice, and therefore can easily be incorporated into preclinical studies for cancer cell-specific or immune cell-targeting drug discovery studies.
Myeloid cell-derived PDGF (zeige PDGFA Proteine) contributes to vascular neotissue formation by regulating macrophage apoptosis, smooth muscle cell proliferation and extracellular matrix deposition.
These results demonstrate the requirement of lymphatic endothelial cells-autonomous PDGFB expression and retention for smooth muscle cell recruitment to lymphatic vessels.
Mechanical strain stimulates vasculogenesis of embryonic stem cells by the intracellular messengers ROS (zeige ROS1 Proteine), NO and calcium as well as by upregulation of angiogenesis guidance molecules and the angiogenic growth factors VEGF (zeige VEGFA Proteine), FGF-2 (zeige FGF2 Proteine) and PDGF (zeige PDGFA Proteine)-BB.
PDGF-B-PDGFRbeta signaling plays a significant role in the development of adipose tissue neovascularization.
data suggest that the stronger fibrotic effect generated by Pdgfa (zeige PDGFA Proteine) overexpression was mediated by Pdgfralpha in cardiac interstitial mesenchymal cells
loss-of-function mutations in PDGFB or PDGFRB (zeige PDGFRB Proteine) cause Primary Familial Brain Calcification.
Results suggest that regional Pax3 (zeige PAX3 Proteine) expression not only marks a novel subset of High-grade Brainstem Glioma but also contributes to PDGF-B-induced brainstem gliomagenesis
High PDGFB expression is associated with liver fibrosis.
Data indicate a significant impairment of the activation mechanisms by PDGF (zeige PDGFA Proteine)-BB was shown after a hammerhead ribozyme targeting the membrane receptor PDGFR-beta (zeige PDGFRB Proteine) was applied.
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
PDGF subunit B
, PDGF, B chain
, platelet-derived growth factor 2
, platelet-derived growth factor B chain
, platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
, platelet-derived growth factor subunit B
, platelet-derived growth factor, beta polypeptide (oncogene SIS)
, proto-oncogene c-Sis
, platelet-derived growth factor B
, v-sis platelet-derived growth factor beta polypeptide (simian sarcoma viral oncogene homolog)
, platelet-derived growth factor beta polypeptide
, Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis)
, pdgf protein
, platelet derived growth factor, B polypeptide
, platelet-derived growth factor B subunit
, Platelet-derived growth factor B chain