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High TrkC mRNA expression appears to be frequent in the sonic hedgehog (zeige SHH Proteine) subgroup and seems not to have a major effect on therapy responsiveness in medulloblastoma patients.
Data show that neurotrophin 3 (zeige NTF3 Proteine) receptor TrkC acts as an activator in tumorigenicity and metastasis of colorectal cancer, and was frequently overexpressed in colorectal cancer (CRC (zeige CALR Proteine)) cells, patients' tumor samples.
LINC00052 could regulate NTRK3 expression by forming complementary base pairing with miR-128 and miR-485-3p to reduce the luciferase activity of NTRK3 3'UTR.
Case Reports: mammary analog secretory carcinoma of the thyroid gland with ETV6 (zeige ETV6 Proteine) rearrangement and ETV6 (zeige ETV6 Proteine)-NTRK3 gene fusion.
The prevalence of ETV6 (zeige ETV6 Proteine)-NTRK3 kinase fusions were determined in papillary thyroid cancer of adult population
We report the case of a patient with an initial diagnosis of salivary acinic cell carcinoma later reclassified as Mammary analogue secretory carcinoma after next-generation sequencing revealed an ETV6-NTRK3 fusion.
Data suggest that kinase domains of neurotrophin (zeige BDNF Proteine) receptor isoforms, TRKA (zeige NTRK1 Proteine), TRKB (zeige NTRK2 Proteine), and TRKC, exhibit a bulky phenylalanine gatekeeper, leading to a small and unattractive back pocket/binding site for antineoplastic kinase inhibitors. [REVIEW]
Pan-Trk (zeige NTRK1 Proteine) immunohistochemistry is a time-efficient and tissue-efficient screen for NTRK fusions, particularly in driver-negative advanced malignancies and potential cases of secretory carcinoma and congenital fibrosarcoma.
5 gastrointestinal stromal tumors cases lacking alterations in the KIT/PDGFRA (zeige PDGFRA Proteine)/SDHx/RAS pathways, including two additional cases with FGFR1 (zeige FGFR1 Proteine)-TACC1 (zeige TACC1 Proteine) and ETV6 (zeige ETV6 Proteine)-NTRK3 fusions, are reported.
High expression of TrkC is associated with glioblastoma.
In a retinitis pigmentosa mouse model, TrkC activity generates phosphorylated Erk (zeige EPHB2 Proteine), which upregulates glial TNF-alpha (zeige TNF Proteine), causing selective neuronal death.
our data suggest that Runx3 (zeige RUNX3 Proteine) may play a crucial role in the development of DRGs by regulating the expression of Ntrk3 variants
adult homozygous TrkAC knock-in mice displayed severe deficits in acute and tissue injury-induced pain, representing the first viable adult Trk (zeige NTRK1 Proteine) mouse mutant with a pain phenotype
TrkC expression in E13.5 VCG neurons requires NeuroD (zeige NEUROD1 Proteine) and that TrkC expression may be necessary for the normal migration and innervations of those neurons.
The dependence receptor TrkC interacts with Cobra1 (zeige COBRA1 Proteine).TrkC killer fragment shuttles with Cobra1 (zeige COBRA1 Proteine) to the mitochondria to engage apoptosis.
ETV6 (zeige ETV6 Proteine)-SAM (zeige TTN Proteine) domain interface mutations block ETV6 (zeige ETV6 Proteine)-NTRK3-induced cellular transformation
This study demonistrated that NTRK3 plays a role in panic disorder by regulating hippocampus-dependent fear memories.
Despite elimination of TrkC mRNA, no differences in development of kindling were detected between TrkC conditional null and wild type control mice.
find that both IRS1 (zeige IRS1 Proteine) and kinase active IGF1R (zeige IGF1R Proteine) are required for ETV6 (zeige ETV6 Proteine)-NTRK3 transformation, that tyrosine phosphorylated IRS1 (zeige IRS1 Proteine) is present in high molecular weight complexes with EN and IGF1R (zeige IGF1R Proteine), and that EN colocalizes with IGF1R (zeige IGF1R Proteine) at the plasma membrane
Data describe the distribution and changes of TrkB (zeige NTRK2 Proteine) and TrkC in the dopamine neurons of the substantia nigra by comparison of control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP (zeige PTPN2 Proteine)) Parkinson disease mouse model.
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene.
ETS related protein-neurotrophic receptor tyrosine kinase fusion protein
, ETV6-NTRK3 fusion
, NT-3 growth factor receptor
, tyrosine kinase receptor C
, neural receptor protein-tyrosine kinase (trkC)
, trkC tyrosine kinase
, neurotrophic tyrosine kinase receptor type 3
, tyrosine kinase C receptor, TrkC receptor, high-affinity neurotrophin receptor
, neurotrophic tyrosine kinase, receptor, type 3
, NT-3 growth factor receptor-like