anti-BDNF (BDNF) Antikörper

Human Brain-Derived Neurotrophic Factor (BDNF) Interaktionspartner

1. Moderation analyses indicated that after controlling for gender, the BDNF Val66Met polymorphism moderated the relationship between exercise and fear recovery 24 h later, such that exercise was associated with greater fear recovery in individuals with the Met allele.

2. Serum BDNF, S100B, and NSE levels appear to be associated with the occurrence of delirium in polytrauma patients.

3. Phylogenetic analysis indicated that the V66M mutation of BDNF occurs at a non-conserved position of the protein. MD analyses indicated that the V66M mutation does not affect the BDNF flexibility and surface-to-volume ratio, but affects the BDNF essential motions, hydrogen-bonding and secondary structure particularly at its pre and pro-domain, which are crucial for its activity and distribution.

4. This study supports the hypothesis that BDNF and S100B neuromodulators present different serum levels according to the background disease associated to the chronic pain.

5. The serum BDNF levels of patients with schizophrenia were remarkably lower than those of controls.

6. Reduced serum levels of BDNF were determined in patients with schizophrenia compared to controls.

7. miR584 may serve tumorsuppressive roles in hepatocellular carcinoma (HCC) by directly targeting BDNF, thus suggesting that miR584 may serve as a potential candidate for treatment of patients with this disease

8. An association was found between low serum BDNF and suicidal ideation in patients with major depressive disorder.

9. Study finds plasma brain-derived neurotrophic factor (BDNF) and sphingosine-1-phosphat (S1P) are NOT the main mediators of neuroprotection induced by resistance training in persons with multiple sclerosis-A randomized controlled trial.

10. The Val66Met BDNF phenotype did not result in differential responses to cadence cycling exercise intervention in Parkinson's patients.

11. carriers of the BDNF Met allele were protected against global subjective Cancer-related cognitive impairment, particularly in the domains of memory, multitasking, and verbal ability.

12. A key neural circuit for cognitive control is influenced by a plasticity-related genetic variant BDNF, which may render this circuit particularly susceptible to genetic and environmental risk factors for schizophrenia.

13. Study in different human cell lines and postmortem neurodegenerative diseases brain samples shows that BDNF-mediated Akt directly phosphorylates AEP on T322 and blocks AEP activation, sequestering it in lysosomes. BDNF reduction in neurodegenerative diseases elicits reduction of p-AEP T322, AEP cytoplasmic translocation, and subsequent activation, escalating its autocleavage and pathological substrate truncation.

14. These results suggest that repetitive transcranial magnetic stimulation may increase BDNF and decrease IL-1beta and TNF-alpha serum levels in elderly patients with refractory depression.

15. In glomeruli of diabetic nephropathy patients, we found a strong BDNF signal in the remaining podocytes. An inhibition of the BDNF receptor TrkB resulted in enhanced podocyte dedifferentiation

16. A significant increase in plasma BDNF levels was seen in patients with schizophrenia treated with n-3 polyunsaturated fatty acid.

17. The BDNF Vall66Met single nucleotide polymorphism is a potential genetic factor that contributes to the heterogeneity of recovery processes among stroke survivors

18. LINC00152 functioned as a competing endogenous RNA to the miR-497 sponge, downregulating its downstream target brain-derived neurotrophic factor, which is an oncogene in papillary thyroid cancer.

19. the BDNF rs6265 polymorphism may have a different impact in Latinos as compared with other previously studied

20. There is a sex-dependent effect of the BDNF Val66Met polymorphism on executive functioning and processing speed in older adults

Mouse (Murine) Brain-Derived Neurotrophic Factor (BDNF) Interaktionspartner

1. Exercise significantly increased BDNF expression and decreased the expression of p75 in both SAMR1 and SAMP8 strains of mice.

2. findings were generalizable to two rodent species with very different social structures and, within mice, to a variety of strains providing converging evidence that BDNF-TrkB signaling reduces anxiety- and depression-like symptoms following short-term social stress.

3. the expression of brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase B (TrkB), was significantly decreased in the hippocampus of ErbB4-deleted mice

4. Study shows that BDNF-mediated Akt directly phosphorylates AEP on T322 and blocks AEP activation, sequestering it in lysosomes. Viral delivery of unphosphorylated T322A mutant into brain of young alpha-SNCA mice accelerates alpha-syn N103 cleavage in alpha-SNCA-Tg mice. Data support the hypothesis that a decrease in BDNF/TrkB signaling in neurodegenerative diseases abolishes p-AEP T322, resulting in AEP upregulation an...

5. decreased release of BDNF in cortical neurons might lead to decreased BDNF levels in the striatum because the striatum receives BDNF mainly from the cortex

6. Activation of BDNF-ERK signaling in the hippocampus was required.

7. These data suggest that dysbiosis differentially influences the expression of BDNF-TrkB in the juvenile mice enteric nervous system and central nervous system.

8. Reduced cortical BDNF expression leads to impairments in the generation of high-frequency neural oscillations.

9. Authors identify a potential role for BDNF in PWS that requires further exploration and may have therapeutic relevance for this complex neuro-behavioral disorder.

10. FTO affects hippocampal function by regulation of BDNF processing.

11. The data suggest that CADPS2-mediated secretion of BDNF/NT-3 may be involved in development and maturation of synapses and in the balance between inhibitory and excitatory synapses.

12. Bdnf removal from the tongue or from all structures in adult mice impacts the way taste nerves project to the first central relay. Deletion of Bdnf from the tongue and from all tissues led to a progressively greater expansion of terminal fields. This demonstrates, for the first time, that BDNF is necessary for the normal maintenance of central gustatory circuits at adulthood.

13. Data suggest that response similar to nicotine withdrawal or/and hypoxia induced by childhood chronic asthma enhances the BDNF-Cdc42/RhoA signaling pathway and activates cofilin1, leading to the remodeling of actin, causing the loss of dendritic spines and atrophy of dendrites, eventually resulting in behavioral alterations.

14. Our findings show that disruption of BDNF from specific promoters leads to distinct body composition effects, with disruption from promoters I or II, but not IV or VI, inducing obesity.

15. Endogenous BDNF might be protective against apoptosis through GADD153 suppression and steatosis via SREBP-1c suppression during ER stress

16. The BDNF Met prodomain renders ventral CA1 - prelimbic projection neurons underdeveloped, preventing their capacity for subsequent circuit modulation necessary for fear extinction.

17. BDNF gene in mice fed high-fat diet was under-expressed by 0.30 fold with respect to chow-fed mice after 3 months of dietary intervention.

18. Results provide evidence of a causal relationship between reduced BDNF function in hippocampus and the anxiety susceptibility of aged mice.

19. Chronic unpredictable mild stress (CUMS) induced depressive-like behaviors and stimulated changes in brain regions expressing different BDNF levels. Depressive-like behaviors and region-specific BOLD activity in BDNF(tm1Krj/J) mice were consistent with those in wild-type CUMS-exposed mice. Findings suggested a potential central role of BDNF expression in functional changes in the brain.

20. Central BDNF, especially subfornical organ BDNF is involved in the maintenance of basal blood pressure and in augmentation of hypertensive response to angiotensin II.

Zebrafish Brain-Derived Neurotrophic Factor (BDNF) Interaktionspartner

1. Zebrafish brain possesses intense neurogenesis that can be correlated with high regenerative properties. Recently, the zebrafish has been proposed as a valid experimental paradigm to study the association of BDNF and neural repair after traumatic brain injury.[review]

2. BDNF is involved in the gonadal function of adult zebrafish, and mainly in the adult ovary.

3. One of the modulators of TOR is brain-derived neurotrophic factor (BDNF), which activates the TOR signaling pathway to promote protein synthesis, synapse strengthening, and the creation of new neural networks.findings demonstrate that TOR activation in old animals occurs in the early phase of consolidation, and follows a pattern identical to that of BDNF expression.

4. These results suggest an involvement of the BDNF/TrkB system in the regulation of food intake and energy balance in zebrafish, as in mammals

5. BDNF-TrkB influences the expression level of components of chemokine signaling including Cxcr4b, and the generation of progenitors of mechanoreceptors, at the level of expression of Atoh1a-Atp2b1a.

6. Light regulates the expression of the BDNF/TrkB2 system in the adult zebrafish retina.

7. Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein.

8. the results demonstrate that bdnf mediates non-cell-autonomous maintenance of position and thereby the identity of differentiated neurons

9. The present results demonstrate that there is a parallel time-related decline in the expression of BDNF and TrkB in zebrafish.

10. The cloning and analysis of three additional zebrafish (Danio rerio) BDNF gene exons and two associated promoters, is reported. Among them are two exons that generate a novel tripartite mature transcript

11. Loss of BDNF is a major cause of the developmental abnormalities seen with huntingtin knockdown in zebrafish.

Xenopus laevis Brain-Derived Neurotrophic Factor (BDNF) Interaktionspartner

1. Together these results suggest an important role of BDNF in the maintenance and regeneration of the olfactory system.

2. BDNF suppresses neuromuscular junction maturation through cAMP-PKA signaling pathway

3. activity-dependent conversion of proBDNF to mBDNF may regulate synapse elimination.

4. Findings demonstrate the neurotrophin, BDNF-dependent formation of integrin beta1-based adhesions in the growth cone and reveal how a positive regulator of substrate adhesions can block the negative remodeling and growth inhibitory effects of myelin-associated glycoprotein .

5. These results indicate that brief sensory stimulation, by initiating nuclear transcription and de novo protein synthesis of BDNF, can facilitate the refinement of response properties in the developing visual system.

6. In the Xenopus melanotrope, BDNF biosynthesis and processing occur along the secretory granule maturation axis, together with that of POMC-derived alphaMSH, and that the light controls the biosynthesis and secretion of BDNF and of POMC end-products.

7. BDNF released from the neural lobe of the pituitary gland acts as a neurohormone stimulating the secretory activity of the melanotrope cells in the intermediate pituitary lobe.

8. BDNF influences synaptic connectivity in multiple ways, promoting not only the morphological maturation of axonal arbors but also their stabilization, but also their stabilization.

9. BDNF, in addition to its neural and hormonal roles, can be released as a neurohormone from the neural pituitary lobe of X. laevis

10. BDNF induces glial cell proliferation as well as axonal outgrowth and myelination in vivo.

11. PACAP stimulates the expression of BDNF transcript IV.

12. The upstream open reading frames of BDNF transcripts I and IV markedly decrease BDNF translation efficiency, giving the first indication for a functional role of untranslated BDNF exons.

Pig (Porcine) Brain-Derived Neurotrophic Factor (BDNF) Interaktionspartner

1. measurement of brain derived neurotrophic factor in serum brings a practical approach to study the effects of environmental enrichment on neurobiological changes in domestic animals

2. Lf upregulated several canonical signaling pathways associated with neurodevelopment and cognition and influenced ~10 genes involved in the brain-derived neurotrophin factor (BDNF) signaling pathway.

3. Taken together, these data indicate that recurrent tethering stress in sows over 4.5 years results in a loss of neurotrophic support by BDNF, mediated by an overactive neuroendocrine system.

4. FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 and MMP-2, caspase-3 and BDNF

Cow (Bovine) Brain-Derived Neurotrophic Factor (BDNF) Interaktionspartner

1. These observations provided evidence that brain-derived naeurotrophic factor(BDNF) and its receptor (BDNF receptor) secreted by bovine sperm was important in regulation of insulin and leptin.

2. Expressed in ganglionic neuron-like tumor cells, which may activate an embryonic pathway involving BDNF.

Rhesus Monkey Brain-Derived Neurotrophic Factor (BDNF) Interaktionspartner

1. Study showed that complex relationships exist between BDNF/TrkB gene expression and interneuron marker gene expression that appear to be dependent on the presence of testosterone at adolescence

2. In a monkey model, cortical BDNF and activity regulated cytoskeletal-associated protein ARC expressions are strongly correlated with spontaneous physical activity.

3. A SNP is present in rhesus macaques and is able to affect BDNF peripheral levels, thus making this primate model a fundamental tool to study gene by environment interactions involving the BDNF gene.

4. In monkey the decline of the BDNF protein level started earlier in the sensory and motor neocortical areas than in the association neocortical areas.