anti-BDNF (BDNF) Antikörper

Human Brain-Derived Neurotrophic Factor (BDNF) Interaktionspartner

1. Authors identify a potential role for BDNF in PWS that requires further exploration and may have therapeutic relevance for this complex neuro-behavioral disorder.

2. having the BDNF rs6265 allele (A) increases the risk of developing major depressive disorder in the Malaysian population

3. the G196A (Val66Met) polymorphism was significantly associated with cognitive impairment in Parkinson's disease, especially in Caucasian populations (Meta-Analysis)

4. These results provide evidence on polymorphism of BDNF / BDNFOS gene associated with Lumbar disc herniation risk in Chinese Han population.

5. Study shows that despite lacking gastric mucosal inflammation, up-regulation of TRPV1 and TRPV2, down-regulation of BDNF were observed in functional dyspepsia (FD) patients. These suggest that immune alteration may contribute to the pathogenesis of FD without any previous infection.

6. some clinical characteristics, including age and cigarettes smoked each day, interacted with the BDNF gene variant and appeared to play an important role in suicide attempts among schizophrenia patients

7. 2 BDNF polymorphisms [p.Val66Met (c.G196A) and c.C270T] were examined for their association with Wilson disease and some of its clinical attributes.The C allele and CC genotype of BDNF C270T were overrepresented among controls vs patients. A higher proportion of the allele coding for Val and the corresponding homozygous genotype of BDNF Val66Met polymorphism occurs in patients with onset at >10 years of age.

8. ut of twenty-seven genes culminating into leading hubs in the network, we identified two key regulators (KRs) i.e. KDM6A and BDNF

9. Serum levels of BDNF, independent of a specific sleep disorder, are related to the proportion of sleep stage N3 and REM sleep.

10. higher serum BDNF predicted greater recovery of pulse pressure after a one-hour rest in female nurses after night shift work

11. These findings evidenced a novel role of BDNF in the modulation of ApoE and cholesterol homeostasis in glial and neuronal cells.

12. Results suggest that polymorphisms of single nucleotide polymorphisms (SNP) of brain derived neurotrophic factor (BDNF) play an important role in lifetime cigarette smoking and cigarette smoking within a 12-month period of susceptibility in the Iranian population.

13. findings from a meta-analytic investigation of published literature provide little support for the Val66Met variant of BDNF as a predictor of obsessive-compulsive disorder; future well-powered agnostic genome-wide association studies with more refined phenotype are needed to clarify genetic influences on OCD

14. Associations of Gene Variations in Neuropeptide Y and Brain Derived Neurotrophic Factor Genes with Posttraumatic Stress Disorder

15. This meta-analysis showed a lack of association between the BDNF 196 G/A and COMT Val158Met polymorphisms and ADHD.

16. this paper shows a strong and positive correlation between BDNF and its antisense RNA, BDNF-AS in multiple sclerosis patients

17. Carrying two copies of the rs6265 Met66 allele ( approximately 4% of the population) is associated with less severity in motor symptoms and potentially a slower rate of progression in Parkinson disease.

18. Our data show that the rs10767664 variant of the BDNF gene modifies insulin resistance and insulin levels after weight loss with a hypocaloric diet enriched with monounsaturated fatty acids (MUFAs).

19. Separate and combined effects of religiosity, child aggression, and BDNF genotype on mothers' and fathers' use of corporal punishment.

20. This review showed the Influence of the Val66Met Polymorphism of Brain-Derived Neurotrophic Factor on Neurological Function after Traumatic Brain Injury.

Mouse (Murine) Brain-Derived Neurotrophic Factor (BDNF) Interaktionspartner

1. Authors identify a potential role for BDNF in PWS that requires further exploration and may have therapeutic relevance for this complex neuro-behavioral disorder.

2. FTO affects hippocampal function by regulation of BDNF processing.

3. The data suggest that CADPS2-mediated secretion of BDNF/NT-3 may be involved in development and maturation of synapses and in the balance between inhibitory and excitatory synapses.

4. Bdnf removal from the tongue or from all structures in adult mice impacts the way taste nerves project to the first central relay. Deletion of Bdnf from the tongue and from all tissues led to a progressively greater expansion of terminal fields. This demonstrates, for the first time, that BDNF is necessary for the normal maintenance of central gustatory circuits at adulthood.

5. Data suggest that response similar to nicotine withdrawal or/and hypoxia induced by childhood chronic asthma enhances the BDNF-Cdc42/RhoA signaling pathway and activates cofilin1, leading to the remodeling of actin, causing the loss of dendritic spines and atrophy of dendrites, eventually resulting in behavioral alterations.

6. Our findings show that disruption of BDNF from specific promoters leads to distinct body composition effects, with disruption from promoters I or II, but not IV or VI, inducing obesity.

7. Endogenous BDNF might be protective against apoptosis through GADD153 suppression and steatosis via SREBP-1c suppression during ER stress

8. The BDNF Met prodomain renders ventral CA1 - prelimbic projection neurons underdeveloped, preventing their capacity for subsequent circuit modulation necessary for fear extinction.

9. BDNF gene in mice fed high-fat diet was under-expressed by 0.30 fold with respect to chow-fed mice after 3 months of dietary intervention.

10. Results provide evidence of a causal relationship between reduced BDNF function in hippocampus and the anxiety susceptibility of aged mice.

11. Chronic unpredictable mild stress (CUMS) induced depressive-like behaviors and stimulated changes in brain regions expressing different BDNF levels. Depressive-like behaviors and region-specific BOLD activity in BDNF(tm1Krj/J) mice were consistent with those in wild-type CUMS-exposed mice. Findings suggested a potential central role of BDNF expression in functional changes in the brain.

12. Central BDNF, especially subfornical organ BDNF is involved in the maintenance of basal blood pressure and in augmentation of hypertensive response to angiotensin II.

13. The data of this study demonstrated that 24 h after fear conditioning, BDNF+/- mice exhibited an impaired fear memory expression.

14. This study demonstrated that Brain-derived neurotrophic factor derived from sensory neurons plays a critical role in chronic pain.

15. Deficiency in MyD88 was associated with decreased BDNF expression. Furthermore, the authors identified a valid kappaB-binding site in the BDNF promoter, consistent with activation of NF-kappaB induced by inflammation.

16. The activation of PKCalpha during plasticity requires both NMDA receptor Ca(2+) flux and autocrine brain-derived neurotrophic factor (BDNF)-TrkB signaling, two pathways that differ vastly in their spatiotemporal scales of signaling

17. BDNF val66met polymorphism modulates the effects of developmental EtOH exposure on hippocampus and anxiety-like behavior.

18. Results show that BDNF haploinsufficiency substantially decreases the neuroprotective effect of the steroid mifepristone on Purkinje neurons. This suggests that a full expression of BDNF is critical to prevent the neurotoxicity induced by the GABAergic network activity.

19. Closer examination of genes implicated in the mechanisms of neuroplasticity, such as the NMDA and AMPA subunits and the BDNF pathway, reveal how wild-type mice upregulate many of these genes in response to stress, but Met allele carriers fail to do so.

20. This study found that BDNF deletion in the adult altered few itch or acute and chronic pain behaviors, beyond sexually dimorphic phenotypes in the tail immersion, histamine, and formalin tests.

Zebrafish Brain-Derived Neurotrophic Factor (BDNF) Interaktionspartner

1. Zebrafish brain possesses intense neurogenesis that can be correlated with high regenerative properties. Recently, the zebrafish has been proposed as a valid experimental paradigm to study the association of BDNF and neural repair after traumatic brain injury.[review]

2. BDNF is involved in the gonadal function of adult zebrafish, and mainly in the adult ovary.

3. One of the modulators of TOR is brain-derived neurotrophic factor (BDNF), which activates the TOR signaling pathway to promote protein synthesis, synapse strengthening, and the creation of new neural networks.findings demonstrate that TOR activation in old animals occurs in the early phase of consolidation, and follows a pattern identical to that of BDNF expression.

4. These results suggest an involvement of the BDNF/TrkB system in the regulation of food intake and energy balance in zebrafish, as in mammals

5. BDNF-TrkB influences the expression level of components of chemokine signaling including Cxcr4b, and the generation of progenitors of mechanoreceptors, at the level of expression of Atoh1a-Atp2b1a.

6. Light regulates the expression of the BDNF/TrkB2 system in the adult zebrafish retina.

7. Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein.

8. the results demonstrate that bdnf mediates non-cell-autonomous maintenance of position and thereby the identity of differentiated neurons

9. The present results demonstrate that there is a parallel time-related decline in the expression of BDNF and TrkB in zebrafish.

10. The cloning and analysis of three additional zebrafish (Danio rerio) BDNF gene exons and two associated promoters, is reported. Among them are two exons that generate a novel tripartite mature transcript

11. Loss of BDNF is a major cause of the developmental abnormalities seen with huntingtin knockdown in zebrafish.

Xenopus laevis Brain-Derived Neurotrophic Factor (BDNF) Interaktionspartner

1. Together these results suggest an important role of BDNF in the maintenance and regeneration of the olfactory system.

2. BDNF suppresses neuromuscular junction maturation through cAMP-PKA signaling pathway

3. activity-dependent conversion of proBDNF to mBDNF may regulate synapse elimination.

4. Findings demonstrate the neurotrophin, BDNF-dependent formation of integrin beta1-based adhesions in the growth cone and reveal how a positive regulator of substrate adhesions can block the negative remodeling and growth inhibitory effects of myelin-associated glycoprotein .

5. These results indicate that brief sensory stimulation, by initiating nuclear transcription and de novo protein synthesis of BDNF, can facilitate the refinement of response properties in the developing visual system.

6. In the Xenopus melanotrope, BDNF biosynthesis and processing occur along the secretory granule maturation axis, together with that of POMC-derived alphaMSH, and that the light controls the biosynthesis and secretion of BDNF and of POMC end-products.

7. BDNF released from the neural lobe of the pituitary gland acts as a neurohormone stimulating the secretory activity of the melanotrope cells in the intermediate pituitary lobe.

8. BDNF influences synaptic connectivity in multiple ways, promoting not only the morphological maturation of axonal arbors but also their stabilization, but also their stabilization.

9. BDNF, in addition to its neural and hormonal roles, can be released as a neurohormone from the neural pituitary lobe of X. laevis

10. BDNF induces glial cell proliferation as well as axonal outgrowth and myelination in vivo.

11. PACAP stimulates the expression of BDNF transcript IV.

12. The upstream open reading frames of BDNF transcripts I and IV markedly decrease BDNF translation efficiency, giving the first indication for a functional role of untranslated BDNF exons.

Pig (Porcine) Brain-Derived Neurotrophic Factor (BDNF) Interaktionspartner

1. measurement of brain derived neurotrophic factor in serum brings a practical approach to study the effects of environmental enrichment on neurobiological changes in domestic animals

2. Lf upregulated several canonical signaling pathways associated with neurodevelopment and cognition and influenced ~10 genes involved in the brain-derived neurotrophin factor (BDNF) signaling pathway.

3. Taken together, these data indicate that recurrent tethering stress in sows over 4.5 years results in a loss of neurotrophic support by BDNF, mediated by an overactive neuroendocrine system.

4. FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 and MMP-2, caspase-3 and BDNF

Cow (Bovine) Brain-Derived Neurotrophic Factor (BDNF) Interaktionspartner

1. These observations provided evidence that brain-derived naeurotrophic factor(BDNF) and its receptor (BDNF receptor) secreted by bovine sperm was important in regulation of insulin and leptin.

2. Expressed in ganglionic neuron-like tumor cells, which may activate an embryonic pathway involving BDNF.

Rhesus Monkey Brain-Derived Neurotrophic Factor (BDNF) Interaktionspartner

1. Study showed that complex relationships exist between BDNF/TrkB gene expression and interneuron marker gene expression that appear to be dependent on the presence of testosterone at adolescence

2. In a monkey model, cortical BDNF and activity regulated cytoskeletal-associated protein ARC expressions are strongly correlated with spontaneous physical activity.

3. A SNP is present in rhesus macaques and is able to affect BDNF peripheral levels, thus making this primate model a fundamental tool to study gene by environment interactions involving the BDNF gene.

4. In monkey the decline of the BDNF protein level started earlier in the sensory and motor neocortical areas than in the association neocortical areas.