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SMN2 ELISA Kit (Survival of Motor Neuron 2, Centromeric) ELISA Kit

SMN2 Reaktivität: Human Colorimetric Sandwich ELISA 0.15 ng/mL - 10 ng/mL Tissue Homogenate
Produktnummer ABIN6959786
Zzgl. Versandkosten $45.00
96 tests
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 9 bis 11 Werktagen
  • Typ Kit
    • Kit
  • Target Survival of Motor Neuron 2, Centromeric (SMN2)
    • Survival of Motor Neuron 2, Centromeric (SMN2)
    • Interferon gamma (IFNG)
    • Histone 3 (H3)
    • Interleukin 10 (IL10)
    • Interleukin 6 (IL6)
    • Interleukin 1, beta (IL1B)
    • Tumor Necrosis Factor alpha (TNF alpha)
    • Interleukin 4 (IL4)
    • Epidermal Growth Factor Receptor (EGFR)
    • Interleukin 2 (IL2)
    • Tumor Protein P53 (TP53)
    • IgG
    • Transforming Growth Factor, beta 1 (TGFB1)
    • Albumin (ALB)
    • Interleukin 1 alpha (IL1A)
    • Interleukin 8 (IL8)
    • Follicle-Stimulating Hormone (FSH)
    • Leptin (LEP)
    • C-Reactive Protein (CRP)
    • IgA
    • Jun Proto-Oncogene (JUN)
    • Insulin (INS)
    • Adiponectin (ADIPOQ)
    • Interleukin 13 (IL13)
    • Interleukin 17A (IL17A)
    • CD40 Ligand (CD40LG)
    • Insulin-Like Growth Factor 1 (IGF1)
    • Interleukin 12 (IL12)
    • Interleukin 5 (IL5)
    • Thrombomodulin (THBD)
    • Chemokine (C-C Motif) Ligand 2 (CCL2)
    • Chemokine (C-C Motif) Ligand 5 (CCL5)
    • Cortisol
    • Intercellular Adhesion Molecule 1 (ICAM1)
    • Luteinizing Hormone (LH)
    • Metalloproteinase Inhibitor 2 (TIMP2)
    • Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2)
    • Caspase 3 (CASP3)
    • Cystatin C (CST3)
    • Prolactin (PRL)
    • Retinol Binding Protein 4, Plasma (RBP4)
    • Interleukin 1 Receptor Antagonist (IL1RN)
    • Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) (MMP9)
    • Platelet-Derived Growth Factor beta Polypeptide (PDGFB)
    • Thyroxine T4 (T4)
    • Annexin A5 (ANXA5)
    • Complement Component 3 (C3)
    • Insulin-Like Growth Factor 2 (IGF2)
    • Erythropoietin (EPO)
    • Fas Ligand (TNF Superfamily, Member 6) (FASL)
    • Mitogen-Activated Protein Kinase 14 (MAPK14)
  • Anwendung
    • ELISA
  • Reaktivität
    • Human
  • Abbildungen verfügbar
  • Methodentyp
    • Sandwich ELISA
  • Analytische Methode
    • Quantitative
  • Detektionsmethode
    • Colorimetric
  • Platte
    • Pre-coated
  • Probe
    • Tissue Homogenate

SMN2 Antigen-Profil

Protein Überblick

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. While mutations in the telomeric copy are associated with spinal muscular atrophy, mutations in this gene, the centromeric copy, do not lead to disease. This gene may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The full length protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Four transcript variants encoding distinct isoforms have been described.

Alternative names and synonyms associated with SMN2

  • survival of motor neuron 2, centromeric (SMN2) Antikörper
  • survival of motor neuron 2, centromeric L homeolog (smn2.L) Antikörper
  • bcd541 Antikörper
  • c-bcd541 Antikörper
  • gemin-1 Antikörper
  • GEMIN1 Antikörper
  • smn2 Antikörper
  • smnc Antikörper
  • TDRD16B Antikörper

Bezeichner auf Proteinebene für SMN2

component of gems 1 , gemin-1 , survival motor neuron protein , tudor domain containing 16B , gemin 1 , survival of motor neuron 2, centromeric L homeolog

6607 Homo sapiens
398438 Xenopus laevis

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