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Dog (Canine) Polyclonal SART3 Primary Antibody für IHC, WB - ABIN2780944
Liu, Li, Kim, Pace, He: HIV-1 Tat protein-mediated transactivation of the HIV-1 long terminal repeat promoter is potentiated by a novel nuclear Tat-interacting protein of 110 kDa, Tip110. in The Journal of biological chemistry 2002
Show all 2 Pubmed References
Cow (Bovine) Polyclonal SART3 Primary Antibody für WB - ABIN2775728
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007
Human Polyclonal SART3 Primary Antibody für ELISA, WB - ABIN546980
Bell, Schreiner, Damianov, Reddy, Bindereif: p110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor. in The EMBO journal 2002
Data suggest that ZIP, USP39, Prp24/p100/SART3, and Prp43 associate to form complex instrumental in spliceosome assembly; ZIP regulates pre-mRNA splicing of USP39 independent of RNA binding; stable 35S tri-snRNP particles are enriched in Cajal body. (ZIP = zinc finger and G-patch domain-containing protein; USP39 = ubiquitin specific peptidase 39; Prp43 = RNA helicase Prp43)
We show that PRP31, a component of U4 snRNP, is modified with K63-linked ubiquitin chains by the PRP19 complex and deubiquitinated by USP15 and its substrate targeting factor SART3. USP15SART3 makes a complex with USP4 and this ternary complex serves as a platform to deubiquitinate PRP31 and PRP3
The complex structure of SART3 nuclear localization signal (NLS) and importin-alpha reveals bipartite binding, and removal of SART3 NLS prevents the entry of USP4 (and USP15) into the nucleus and abrogates the subsequent deubiquitinase activity of USP4.
crystal structures of SART3 in the apo-form and in complex with the DUSP-UBL domain of USP15 at 2.0 and 3.0 A, respectively. Structural analysis reveals SART3 contains 12 half-a-tetratricopeptide (HAT) repeats, organized into two subdomains, HAT-N and HAT-C. SART3 dimerizes through the concave surface of HAT-C, whereas the HAT-C convex surface binds USP15 in a novel bipartite mode.
miR-124 regulates Tip110 expression and differentiation of human cord blood CD34(+) cells
Hypoxia led to Tip110 protein degradation through the ubiquitin-proteasome system. Under hypoxia, Tip110 stabilized p53, which in return destabilized Tip110.
SART3 recruits ubH2B, which may be evicted from DNA during transcription, for deubiquitination by Usp15
these findings have provided additional and mechanistic evidence to support Tip110 function in HIV-1 transcription.
Results identify a novel frameshift mutation in this gene implicated in disseminated superficial actinic porokeratosis in 4 Chinese families
YB-1 potentiates the Tip110/Tat-mediated transactivation of the HIV-1 LTR promoter.
findings show C-MYC upregulates transcription of TIP110 through interaction with the TIP110 E-box in the TIP110 promoter, ensuring high-level Tip110 expression in proliferating embryonic stem cells (hESCs); further show TIP110 regulates OCT4 alternative splicing in hESCs
TIP110 is also expressed in human embryonic stem cells (hESCs) and expression was decreased with differentiation of these ESCs.
detectable in majority of colorectal carcinoma tissues studied; could be an appropriate molecule for use in specific immunotherapy for colorectal carcinoma
Results suggest that U4 and U6 small nuclear ribonucleoproteins (snRNPs) accumulate in Cajal bodies for the purpose of assembly into U4/U6 snRNPs by SART3/p110.
involvement of U6-p110 (SART3) in recycling of the U4atac/U6atac snRNP
Tip110 is a negative regulator of AR transcriptional activation, and may be directly involved in AR-related developmental, physiological, and pathological processes
Data suggest a model whereby p110 (SART3) brings together U4 and U6 snRNAs through both RNA-protein and protein-protein interactions.
Both purified and recombinant LSm2-8 proteins are able to recruit p110 protein to U6 snRNA via interaction with the highly conserved C-terminal region of p110.
Levels of anti-SART3 peptide antibody in prostate cancer patients are significantly higher than those of non-cancer subjects.
The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing.
squamous cell carcinoma antigen recognized by T cells 3
, Squamous cell carcinoma antigen recognized by T-cells 3
, squamous cell carcinoma antigen recognized by T-cells 3-like
, earl grey
, squamous cell carcinoma antigen recognized by T-cells 3
, tat-interacting protein of 110 kDa
, tumor-rejection antigen SART3