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Human Polyclonal NCBP1 Primary Antibody für WB - ABIN1881565
Hwang, Sato, Tang, Matsuda, Maquat: UPF1 association with the cap-binding protein, CBP80, promotes nonsense-mediated mRNA decay at two distinct steps. in Molecular cell 2010
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Data show that Cbp80 knockdown not only led to the upregulation of transposons, but also to delocalization of Piwi (zeige PIWIL1 Antikörper), Aub and Ago3 (zeige EIF2C3 Antikörper), key factors in the piRNA biosynthesis pathway.
Sgf11 interacts with the cap-binding protein 80 (Cbp80) component of the cap-binding complex, and that Cbp80 knockdown interferes with Sgf11 recruitment on the hsp70 promoter.
Study proposes the existence of an alternative cap-binding complex involving NCBP1 and NCBP3 that plays a key role in mRNA biogenesis.
down-regulation of CTIF (zeige KIAA0427 Antikörper) using a small interfering RNA causes a redistribution of CBP80 from polysome fractions to subpolysome fractions, without significant consequence to eIF4E (zeige EIF4E Antikörper) distribution
Cellular processes by which CBP80-CBP20 (zeige NCBP2 Antikörper) -bound messenger ribonucleoproteins (mRNPs) are remodeled to eIF4E (zeige EIF4E Antikörper)-bound mRNPs, are overviewed.
Viral mRNA associates with the influenza virus A NS1 (zeige PTPN11 Antikörper) and the cellular NCBP1 of the nuclear cap-binding complex.
UPF1 (zeige UPF1 Antikörper) binds PTC (zeige F9 Antikörper)-containing mRNA more efficiently than the corresponding PTC (zeige F9 Antikörper)-free mRNA in a way that is promoted by the UPF1 (zeige UPF1 Antikörper)-CBP80 interaction.
crystal structure at 2.1 A resolution of CBP20 (zeige NCBP2 Antikörper) and CBP80 bound to an m(7)GpppG cap analogue
Structural basis of m7GpppG binding to the nuclear cap-binding protein (zeige EIF4E Antikörper) complex.
The organization of the CBP80-CBP20 (zeige NCBP2 Antikörper) complex suggests how the activity of eIF4G (zeige EIF4G1 Antikörper) in translation initiation could be regulated through a dynamic network of overlapping intra- and intermolecular interactions.
During nonsense-mediated mRNA decay, CBP80 interacts with Upf1 (zeige UPF1 Antikörper) and promotes the interaction of Upf1 (zeige UPF1 Antikörper) with Upf2 (zeige UPF2 Antikörper) but not with Stau1 (zeige STAU1 Antikörper).
Association of CBC with PARN (zeige PARN Antikörper) might have importance in the regulated recruitment of PARN (zeige PARN Antikörper) to the nonsense-mediated decay pathway during the pioneer round of translation.
the identification of new genes involved in ABA-dependent abiotic stresses using Arabidopsis suppressor mutants of abh1 (zeige ALKBH Antikörper) hypersensitivity to ABA during seed germination.
Data suggest that CBP20 (zeige NCBP2 Antikörper) and CBP80 (ABH1) have synergistic roles during the salt stress response.
SERRATE, CAP BINDING PROTEIN20 (CBP20 (zeige NCBP2 Antikörper)), and CBP80 are regulators of lincRNA expression and biogenesis. RT-PCR experiments confirmed these three proteins are also needed for splicing of a small group of intron-containing lincRNAs.
This intron suppression of transgene silencing requires efficient intron splicing and is dependent on ABH1 (zeige ALKBH Antikörper).
ABH1 (CBP80) encodes a large subunit of CBC (CAP BINDING COMPLEX) and the abh1 (zeige ALKBH Antikörper) mutant is drought-tolerant and hypersensitive to ABA during seed germination.
The cbp80(abh1) and cbp20 (zeige NCBP2 Antikörper)/80 mutants had many more changes in alternative splicing in common than did cbp20 (zeige NCBP2 Antikörper) and cbp20 (zeige NCBP2 Antikörper)/80 suggesting that CBP80 plays a more significant role in alternative splicing than CBP20 (zeige NCBP2 Antikörper).
Abh1 (zeige ALKBH Antikörper) lesion affects several developmental processes, perhaps because the processing of certain mRNAs.
CBP20 and CBP80 function in miRNA biogenesis by binding to pri-miRNA transcripts, and are stabilized by ABA by a post-translational mechanism.
AtCBP80 is required for the stability of AtCBP20 (zeige NCBP2 Antikörper) in the plant cell.
The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay.
, Cap-binding protein 80
, nuclear cap-binding protein subunit 1
, NCBP 80 kDa subunit
, 80 kDa nuclear cap-binding protein
, nuclear cap-binding protein subunit 1-B
, nuclear cap binding protein subunit 1, 80kDa
, nuclear cap-binding protein subunit 1-like
, nuclear cap-binding protein subunit 1-A