NCBP1 Antikörper (C-Term)

Produktnummer ABIN1881565

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch NCBP1 in WB. Es zeigt Reaktivität gegenüber Proben von Human. Es wurde in 5+ Publikationen zitiert.

Kurzübersicht für NCBP1 Antikörper (C-Term) (ABIN1881565)

Target: NCBP1 (Nuclear Cap Binding Protein Subunit 1, 80kDa (NCBP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NCBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB41850

Produktdetails anti-NCBP1 Antikörper

Bindungsspezifität: AA 647-675, C-Term

Homologie: M, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This NCBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 647-675 amino acids from the C-terminal region of human NCBP1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-NCBP1 Antikörper (ABIN1881565)

Hwang, Sato, Tang, Matsuda, Maquat: "UPF1 association with the cap-binding protein, CBP80, promotes nonsense-mediated mRNA decay at two distinct steps." in: Molecular cell, Vol. 39, Issue 3, pp. 396-409, (2010) (PubMed).

Kim, Cho, Choi, Kim, Kim, Ko, Jang, Kim: "A new MIF4G domain-containing protein, CTIF, directs nuclear cap-binding protein CBP80/20-dependent translation." in: Genes & development, Vol. 23, Issue 17, pp. 2033-45, (2009) (PubMed).

Dias, Wilson, Rojas, Ambrosio, Cerione: "The molecular basis for the regulation of the cap-binding complex by the importins." in: Nature structural & molecular biology, Vol. 16, Issue 9, pp. 930-7, (2009) (PubMed).

Worch, Jankowska-Anyszka, Niedzwiecka, Stepinski, Mazza, Darzynkiewicz, Cusack, Stolarski: "Diverse role of three tyrosines in binding of the RNA 5' cap to the human nuclear cap binding complex." in: Journal of molecular biology, Vol. 385, Issue 2, pp. 618-27, (2009) (PubMed).

Ma, Yoon, Richardson, Jülich, Blenis: "SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs." in: Cell, Vol. 133, Issue 2, pp. 303-13, (2008) (PubMed).

Details zu NCBP1

Target: NCBP1 (Nuclear Cap Binding Protein Subunit 1, 80kDa (NCBP1))

Andere Bezeichnung: NCBP1

Hintergrund: The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay.

Molekulargewicht: 91839

NCBI Accession: NP_002477

UniProt: Q09161

Pathways: Ribonucleoprotein Complex Subunit Organization, Photoperiodism, Methionine Biosynthetic Process