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RIPK1 Proteine

(Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))
Serine-threonine kinase which transduces inflammatory and cell-death signals (necroptosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necroptosis-inducing complex.

Häufig verwendete RIPK1 Proteine

Aktuelle Publikationen für unsere RIPK1 Proteine

Boutaffala, Bertrand, Remouchamps, Seleznik, Reisinger, Janas, Bénézech, Fernandes, Marchetti, Mair, Ganeff, Hupalowska, Ricci, Becher, Piette, Knolle, Caamano, Vandenabeele, Heikenwalder, Dejardin: "NIK promotes tissue destruction independently of the alternative NF-κB pathway through TNFR1/RIP1-induced apoptosis." in: Cell death and differentiation, Vol. 22, Issue 12, pp. 2020-33, (2015) (PubMed).

Fuller, Osborne, Leonard, Hardyman, Vaniotis, Allen, Sugden, Clerk: "Cardiac protein kinases: the cardiomyocyte kinome and differential kinase expression in human failing hearts." in: Cardiovascular research, Vol. 108, Issue 1, pp. 87-98, (2015) (PubMed).

Aliase für RIPK1 Proteine

receptor interacting serine/threonine kinase 1 (RIPK1) Proteine
receptor (TNFRSF)-interacting serine-threonine kinase 1 (Ripk1) Proteine
receptor interacting serine/threonine kinase 1 (Ripk1) Proteine
receptor interacting serine/threonine kinase 1 L homeolog (ripk1.L) Proteine
D330015H01Rik Proteine
Rinp Proteine
RIP Proteine
RIP1 Proteine
Rip1 Proteine
rip1 Proteine
ripk1 Proteine
xrip1 Proteine
xRIP1beta Proteine
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