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RIPK1 Proteine

(Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))
Serine-threonine kinase which transduces inflammatory and cell-death signals (necroptosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necroptosis-inducing complex.

17 Treffer

custom-made RIPK1 Spezies: Human Wirt: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Produktnummer ABIN7555218
 
custom-made RIPK1 Spezies: Maus Wirt: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Produktnummer ABIN7563883
 
RIPK1 Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AP, AA
Pubmed 2 Referenzen
Produktnummer ABIN1318108
 
RIPK1 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Produktnummer ABIN7124799
 
RIPK1 Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AP, AA
Produktnummer ABIN1318110
 
RIPK1 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant SDS, WB, ELISA
Produktnummer ABIN7579244
 
RIPK1 Spezies: Human Wirt: Insektenzellen Recombinant 70 % - 90 % Func Active
Produktnummer ABIN5509127
 
RIPK1 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % SDS, WB, PC, Imm
Produktnummer ABIN7407070
 
RIPK1 Spezies: Ratte Wirt: Escherichia coli (E. coli) Recombinant > 95 % SDS, WB, PC, Imm
Produktnummer ABIN7407073
 
custom-made RIPK1 Spezies: Maus Wirt: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). SDS, WB, ELISA
Produktnummer ABIN3135313
 
custom-made RIPK1 Spezies: Human Wirt: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). SDS, WB, ELISA
Produktnummer ABIN3095020
 
RIPK1 Spezies: Drimia maritima (Sea squill) (Charybdis maritima) Wirt: Escherichia coli (E. coli) Recombinant > 90 % SDS
Produktnummer ABIN5710700
 
RIPK1 Spezies: Bryonia dioica (Red bryony) Wirt: Escherichia coli (E. coli) Recombinant > 90 % SDS
Produktnummer ABIN5710918
 
RIPK1 Spezies: Drimia maritima (Sea squill) (Charybdis maritima) Wirt: Hefe Recombinant > 90 % SDS
Produktnummer ABIN5713982
 
RIPK1 Spezies: Momordica charantia (Bitter gourd) (Balsam pear) Wirt: Hefe Recombinant > 90 % SDS
Produktnummer ABIN5714046
 
RIPK1 Spezies: Bryonia dioica (Red bryony) Wirt: Hefe Recombinant > 90 % SDS
Produktnummer ABIN5714110
 
RIPK1 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant WB, PC
Produktnummer ABIN2751278
 
  • Typ Protein
    • Protein
  • Anwendung
    • SDS-PAGE (SDS)
    • Western Blotting (WB)
    • ELISA
    • Positive Control (PC)
    • Affinity Purification (AP)
    • Antibody Array (AA)
    • Immunogen (Imm)
    • Functional Studies (Func)
  • Reaktivität
    • Human
    • Bryonia dioica (Red bryony)
    • Drimia maritima (Sea squill) (Charybdis maritima)
    • Mouse
    • Momordica charantia (Bitter gourd) (Balsam pear)
    • Rat
  • In Publikationen zitiert
  • Abbildungen verfügbar
  • Carrier free only
  • Wirt
    • Escherichia coli (E. coli)
    • Yeast
    • Cell-free protein synthesis (CFPS)
    • HEK-293 Cells
    • Wheat germ
    • Insect Cells
  • Bindungsspezifität
    • AA 1-671
    • AA 1-257
    • AA 1-656
    • AA 24-247
    • full length
    • AA 1-179
    • AA 17-289
    • AA 24-269
    • AA 292-438
    • AA 562-671
    • partial
  • Konjugat
    • His tag
    • GST tag
    • His-SUMO Tag
    • Strep Tag
    • Unkonjugiert
  • Protein-Typ
    • Recombinant
  • Format
    • Liquid
    • Lyophilized
  • Biologische Aktivität
    • Biologically Active
  • Grade
    • custom-made
  • Hersteller
    • antibodies-online
    • Signalway
    • FabGennix

Aktuelle Publikationen für unsere RIPK1 Proteine

Boutaffala, Bertrand, Remouchamps, Seleznik, Reisinger, Janas, Bénézech, Fernandes, Marchetti, Mair, Ganeff, Hupalowska, Ricci, Becher, Piette, Knolle, Caamano, Vandenabeele, Heikenwalder, Dejardin: "NIK promotes tissue destruction independently of the alternative NF-κB pathway through TNFR1/RIP1-induced apoptosis." in: Cell death and differentiation, Vol. 22, Issue 12, pp. 2020-33, (2015) (PubMed).

Fuller, Osborne, Leonard, Hardyman, Vaniotis, Allen, Sugden, Clerk: "Cardiac protein kinases: the cardiomyocyte kinome and differential kinase expression in human failing hearts." in: Cardiovascular research, Vol. 108, Issue 1, pp. 87-98, (2015) (PubMed).

Aliase für RIPK1 Proteine

receptor interacting serine/threonine kinase 1 (RIPK1) Proteine
receptor (TNFRSF)-interacting serine-threonine kinase 1 (Ripk1) Proteine
receptor interacting serine/threonine kinase 1 (Ripk1) Proteine
receptor interacting serine/threonine kinase 1 L homeolog (ripk1.L) Proteine
D330015H01Rik Proteine
Rinp Proteine
RIP Proteine
RIP1 Proteine
Rip1 Proteine
rip1 Proteine
ripk1 Proteine
xrip1 Proteine
xRIP1beta Proteine
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