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anti-Human CTBP1 Antikörper:
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Human Polyclonal CTBP1 Primary Antibody für ICC, IP - ABIN192430
Valenta, Lukas, Doubravska, Fafilek, Korinek: HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies. in The EMBO journal 2006
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Human Polyclonal CTBP1 Primary Antibody für ICC, IF - ABIN4300741
Huang, Kesselman, Kizub, Guerrero-Preston, Ratovitski: Phospho-?Np63?/microRNA feedback regulation in squamous carcinoma cells upon cisplatin exposure. in Cell cycle (Georgetown, Tex.) 2013
Dog (Canine) Polyclonal CTBP1 Primary Antibody für IHC, WB - ABIN2779661
Lin, Liang, Sun, Liang, Shi, Brunicardi, Shi, Feng: Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription. in Molecular and cellular biology 2003
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CtBP promotes metastasis of breast cancer through repressing cholesterol and activating TGF-beta signaling
A novel CTBP1/CYP19A1/Estradiol axis that explains, in part, the mechanism for prostate tumor growth increase by MeS.
identified a new molecular mechanism to explain PCa and MeS link based on CLCA2 repression by CTBP1 and miR-196b-5p molecules that might act as key factors in the progression onset of this disease
Here, multi-angle light scattering (MALS) data established the NAD(+)- and NADH-dependent assembly of CtBP1 and CtBP2 into tetramers.
The data demonstrated that CtBP1 directly bound to the promoters of MPC1 and MPC2 and transcriptionally repressed them, leading to increased levels of free NADH in the cytosol and nucleus, thus positively feeding back CtBP1's functions.
F-box only protein 32 (FBXO32) directly ubiquitinates C-terminal binding protein 1 (CtBP1), which is required for its stability and nuclear retention.
As part of a complex including PI4KIIIbeta, a 14-3-3gamma dimer, as well as to ARF and the PKD and PAK kinases, BARS binds to and activates a trans-Golgi lysophosphatidic acid (LPA) acyltransferase type delta (LPAATdelta) that converts LPA into phosphatidic acid (PA); and that this reaction is essential for fission of post-Golgi transport carriers.
through targeting CtBP1-mediated suppression of the Epithelial-mesenchymal transition process, miR-644a might suppress the tumor metastasis of gastric cancer cells
Overall, our findings reveal that CtBP1/2 is essential to promote to human glioma cell growth through maintaining the DNA stability regulated by the MRN/ATR/Chk1/CDK2/HIF-1alpha signaling pathway.
A review of CtBP structure, role in tumor progression, and discovery and development of CtBP inhibitors that target CtBP's dehydrogenase activity and other functions, with a focus on the theory and rationale behind the designs of current inhibitors. [review]
miR-644a/CTBP1/p53 have roles in suppressing breast cancer drug resistance by inhibiting cell survival and epithelial-mesenchymal transition
Study reports a recurrent de novo C-terminal binding protein 1 (CTBP1) mutation is associated with developmental delay, hypotonia, ataxia, and tooth enamel defects. This is the first report of mutations within CTBP1 in association with any human disease.
Pinin and CtBP1 and CtBP2 are oncotargets that closely interact with each other to regulate transcription and pre-mRNA alternative splicing and promote cell adhesion and other epithelial characteristics of ovarian cancer cells.
the importance of the oligomeric state of CtBP for coactivation of NeuroD1-dependent transcription, was investigated.
C-terminal binding protein 1 is a critical factor linking changes in cell metabolism to cell phenotype in hypoxic and other forms of pulmonary hypertension
CtBP1 increased breast tumor growth in MeS mice modulating multiple genes and miRNA expression implicated in cell proliferation, progenitor cells phenotype, epithelial to mesenchymal transition, mammary development and cell communication in the xenografts.
These data uncovered that CtBP1 protein is a valuable marker of glioma pathogenic process and that CtBP1 can serve as a novel prognostic marker for glioma therapy.
human chorionic gonadotropin stimulated miR-212, which down-regulated OLFM1 and CTBP1 expression in fallopian and endometrial epithelial cells to favor spheroid attachment
It is a putative target gene of miR-137 in breast neoplasms.
CtBP physically interacted with TCF-4, and this interaction was significantly inhibited in the presence of MTOB. The above findings point to a novel role of CtBPs in the promotion of CSC growth and self-renewal
validated as novel and reliable, tissue-specific reference gene in qRT-PCR studies of postnatal mammary gland development
CtBP1 protein is not essential for the formation of functional ribbon synapses in the retina.
Study demonstrates differential regional and subcellular expression patterns for CtBP1 and CtBP2 in brain and reveals a previously unknown synaptic localization for CtBP2 in particular brain regions.
CtBp proteins repress transcription in a histone deacetylase dependent or independent manner.
The leukemia-associated transcription repressor AML1/MDS1/EVI1 requires CtBP to induce abnormal growth and differentiation of murine hematopoietic cells.
Mice harboring various combinations of Ctbp1 and Ctbp2 mutant alleles exhibit dosage-sensitive defects in a wide range of developmental processes
Genetic knockout of Cbtp1 in mouse embryo fibroblasts upregulates several genes involved in apoptosis.
Smad6 repressed bone morphogenetic protein-induced Id1 transcription through recruiting transcriptional corepressor C-terminal binding protein (CtBP).
Mono-ADP-ribosylation of CtBP1/BARS inactivates its repressor function, which leads to the activation of genes that regulate neutral lipid storage.
p19Arf inhibits the invasion of hepatocellular carcinoma cells by binding to C-terminal binding protein.
basic Kruppel-like factor gene (Klf3) has a role with CtBP in adipogenesis
The regulated docking of the CtBP proteins on PRDM16 controls the brown and white fat-selective gene programs.
CtBP knockout increases Bax transcription, ablates mitochondrial morphology and reduces mitochondrial activities
CtBP1 expressed in human CD4(+) T cells crucially contribute to Th1/Th2 differentiation via selective down-regulation of IL-4 synthesis.
Data show that inhibition of the white adipocyte genes depends on PPARgamma and the expression of C/EBPalpha and the corepressors, carboxy-terminal binding proteins 1 and 2 (CtBP1/2).
In zebrafish hair cells exogenous Ribeye B-domain and CtBP1 localize to the basal ends of synaptic ribbons.
Tel orchestrates endothelial sprouting by binding to the generic co-repressor, CtBP
This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.
C-terminal-binding protein 1
, brefeldin A-ribosylated substrate
, 50 kDa BFA-dependent ADP-ribosylation substrate
, 50-kDa BFA-induced ADP-ribosylated substrate
, C-terminal-binding protein 3
, C-terminus binding protein 3/brefeldin A (BFA) adenosine diphosphate-ribosylated substrate
, brefeldin A-ADP-riboslyated substrate
, C-terminal-binding protein A
, C-terminal binding protein 1
, C-terminal-binding protein 1-like
, c-terminal-binding protein 1-like
, LOW QUALITY PROTEIN: C-terminal-binding protein 1