CTBP1 Antikörper (C-Term)

Produktnummer ABIN3043816

Produktdetails anti-CTBP1 Antikörper

Target: CTBP1 (C-terminal Binding Protein 1 (CTBP1))

Bindungsspezifität: AA 409-440, C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CTBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for C-terminal-binding protein 1(CTBP1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Sequenz: HGLPPVAHPP HAPSPGQTVK PEADRDHASD QL

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for C-terminal-binding protein 1(CTBP1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: C-terminal binding protein 1
Protein Name: C-terminal-binding protein 1

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human CtBP1 (409-440aa HGLPPVAHPPHAPSPGQTVKPEADRDHASDQL), different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu CTBP1

Target: CTBP1 (C-terminal Binding Protein 1 (CTBP1))

Andere Bezeichnung: CTBP1 (CTBP1 Produkte)

Synonyme: BARS antikoerper, CtBP1-L antikoerper, CtBP1-S antikoerper, CtBP3/BARS antikoerper, D4S115h antikoerper, D5H4S115 antikoerper, D5H4S115E antikoerper, 50-kDaBFA-inducedADP-ribosylatedsubstrate antikoerper, BARS-50 antikoerper, Bars antikoerper, wu:fi43a11 antikoerper, CtBP antikoerper, ctbp1-A antikoerper, xctbp1 antikoerper, bars antikoerper, CTBP1 antikoerper, C-terminal binding protein 1 antikoerper, C-terminal binding protein 1 L homeolog antikoerper, CTBP1 antikoerper, Ctbp1 antikoerper, ctbp1 antikoerper, ctbp1.L antikoerper

Hintergrund: CTBP1, C-terminal-binding protein 1, is a protein that in humans is encoded by the CTBP1 gene. The CtBP1 protein binds to the C-terminus of adenovirus E1A proteins. This gene is mapped to 4p16.This phosphoprotein is a transcriptional repressor (corepressor) and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. CtBP1 and CtBP2 preferentially associate with the E1A via a 5 amino acid motif, PLDLS, to repress E1A induced oncogenesis and cellular transformation. CtBP1 is expressed from embryo to adult, but CtBP2 is mainly expressed during embryogenesis. During skeletal and T cell development, CtBP1 and CtBP2 associate with the PLDLSL domain of δEF1, a cellular zinc finger-homeodomain protein, and thereby enhances δEF1-induced transcriptional silencing. In addition, CtBP complexes with CtIP, a 125 kDa protein that recognizes distinctly different protein motifs from CtBP. CtIP binds to the BRCT repeats within the breast cancer gene BRCA1 and enables CtBP to influence BRCA1 activity. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.

Synonyms: BARS antibody|brefeldin A- ribosylated substrate antibody|C terminal binding protein 1 antibody|C-terminal-binding protein 1 antibody|CTBP antibody|CtBP1 antibody|Ctbp1 antibody| CTBP1_HUMAN antibody|MGC104684 antibody

Gen-ID: 1487

UniProt: Q13363

Pathways: Retinoic Acid Receptor Signaling Pathway