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CD9 (zeige CD9 Proteine) stabilizes gp130 (zeige IL6ST Proteine) by blocking its ubiquitin-dependent lysosomal degradation to promote the IL6 (zeige IL6 Proteine)-gp130 (zeige IL6ST Proteine)-bone marrow X-linked non-receptor tyrosine kinase (zeige TNK1 Proteine)-STAT3 (zeige STAT3 Proteine) signaling for maintaining GSC (zeige GSC Proteine) selfrenewal and tumorigenic capacity.
CD9 (zeige CD9 Proteine) was highly expressed on extravillous trophoblast (EVT) at the boundary region of EVT invasion and intravascular EVT. CD9 (zeige CD9 Proteine) expression on Swan71 cells was reduced under hypoxic conditions, while its expression was increased by co-culture with HUVEC. CD9 (zeige CD9 Proteine) could attenuate EVT invasion under the influence of an oxygen environment and maternal endothelial cells, proposing CD9 (zeige CD9 Proteine) as a potential regulator of human placentation.
As for 18Lin(-), CD34 (zeige CD34 Proteine)(-) HSCs are characterized by low expression of the tetraspanin CD9 (zeige CD9 Proteine), which promotes homing, and high expression of the peptidase CD26 (zeige DPP4 Proteine), which inhibits homing.
The findings suggest that, in contrast with previous models, the ligand-binding site of integrin alphaVbeta3 (zeige ITGAV Proteine), binds to the constant region (helices A and B) of the EC2 (zeige TCF15 Proteine) domain of CD9 (zeige CD9 Proteine), CD81 (zeige CD81 Proteine), and CD151 (zeige CD151 Proteine) antigens.
Data suggest that CD9 (zeige CD9 Proteine) should be further evaluated as a target for glioblastoma treatment.
Collectively, using tetraspanin CD9 (zeige CD9 Proteine) in tandem with E-cadherin (zeige CDH1 Proteine) as a biomarker in renal cell carcinoma (zeige MOK Proteine) will help to not only distinguish between types, but also predict the metastatic potential of RCC (zeige XRCC1 Proteine).
Data indicate that CD9 (zeige CD9 Proteine) is implicated in BCC invasiveness and metastases by cellular mechanisms that involve specific CD9 (zeige CD9 Proteine)+ plasma membrane protrusions of BCCs.
CD9 (zeige CD9 Proteine)-enriched microdomains negatively regulate LPS (zeige IRF6 Proteine)-induced receptor formation by preventing CD14 (zeige NDUFA2 Proteine) from accumulating into lipid rafts. [Review]
Results indicate that CD9 (zeige CD9 Proteine) downregulation promoted pancreatic cancer cell proliferation and migration through at least in part, enhancing the cell surface expression of EGFR (zeige EGFR Proteine).
CD9 (zeige CD9 Proteine) expression is upregulated and its expression is correlated with tumor stage and lymph node metastasis in esophageal squamous cell carcinoma patients
Mice lacking RXRalpha (zeige RXRA Proteine) in myeloid cells exhibit reduced levels of CCL6 (zeige CCL6 Proteine) and CCL9 (zeige Ccl9 Proteine), impaired recruitment of leukocytes to sites of inflammation, and lower susceptibility to sepsis.
enhanced expression in intestinal epithelium following immunostimulation with LPS (zeige TLR4 Proteine) or pro-inflammatory cytokines
the injury-induced expression of C10 (zeige C12orf57 Proteine) at the mRNA and protein level
c10 (zeige C12orf57 Proteine) promotes fibrosis by recruiting macrophages in the inflammatory response to bleomycin in the lung
CCL6 (zeige CCL6 Proteine) gene activation and production induced by SCF (zeige KITLG Proteine) in the presence or absence of rather specific inhibitors for certain pathways demonstrated that the MEK (zeige MDK Proteine)/MAPK (zeige MAPK1 Proteine) pathway but not the PI-3K pathway was crucial for the SCF (zeige KITLG Proteine)-induced CCL6 (zeige CCL6 Proteine) gene activation.
the chemokines CCL6 (zeige CCL6 Proteine) and CCL9 (zeige Ccl9 Proteine) as genes prominently induced by the type I IFNs and ICSBP (zeige IRF8 Proteine)
This gene encodes a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins are cell surface glycoproteins with four transmembrane domains that form multimeric complexes with other cell surface proteins. The encoded protein functions in many cellular processes including differentiation, adhesion, and signal transduction, and expression of this gene plays a critical role in the suppression of cancer cell motility and metastasis.
ATP-binding cassette sub-family C ( CFTR/MRP) member 1a
, ATP-binding cassette sub-family C member 1
, ATP-binding cassette, sub-family C (CFTR/MRP), member 1
, LTC4 transporter
, leukotriene C(4) transporter
, multidrug resistance protein 1
, multidrug resistance-associated protein 1
, multiple drug resistance-associated protein
, 5H9 antigen
, BA-2/p24 antigen
, CD9 antigen
, CD9 antigen (p24)
, cell growth-inhibiting gene 2 protein
, leukocyte antigen MIC3
, motility related protein-1
, C-C motif chemokine 6
, CC chemokine C10
, small inducible cytokine A6
, small-inducible cytokine A6