MRP1 Protein (Fc Tag)

Produktnummer ABIN6964296

Produktdetails

Target: MRP1 (Macrophage Inflammatory Protein Related Protein 1 (MRP1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses MRP1 Protein ist gelabelt mit Fc Tag.

Sequenz: MRP1(Met1-Phe33)+hFc(Glu99-Ala330)

Produktmerkmale: Tagged Protein: C-Human Fc tag

Aufreinigung: affinity purification

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute with deionized water

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Konservierungsmittel: Without preservative

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C for 12 months (Avoid repeated freezing and thawing)

Haltbarkeit: 12 months

Antigendetails

Target: MRP1 (Macrophage Inflammatory Protein Related Protein 1 (MRP1))

Andere Bezeichnung: MRP1 (MRP1 Produkte)

Synonyme: Abcc1a Protein, Avcc1a Protein, Mrp Protein, Mrp1 Protein, BTCC-1 Protein, DRAP-27 Protein, MIC3 Protein, MRP-1 Protein, TSPAN-29 Protein, TSPAN29 Protein, Scya6 Protein, c10 Protein, ATP binding cassette subfamily C member 1 Protein, CD9 molecule Protein, chemokine (C-C motif) ligand 6 Protein, Abcc1 Protein, CD9 Protein, Ccl6 Protein

Hintergrund: Synonymes: HDMX, MDMX, MRP1
Description: This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]

Molekulargewicht: 29.15 kDa

UniProt: P33527

Pathways: Response to Water Deprivation, Cell-Cell Junction Organization