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Fruit Fly (Drosophila melanogaster) Monoclonal FMR1 Primary Antibody für ICC, IF - ABIN108599
Wan, Dockendorff, Jongens, Dreyfuss: Characterization of dFMR1, a Drosophila melanogaster homolog of the fragile X mental retardation protein. in Molecular and cellular biology 2000
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Fruit Fly (Drosophila melanogaster) Monoclonal FMR1 Primary Antibody für ICC, IF - ABIN108598
Callan, Clements, Ahrendt, Zarnescu: Fragile X Protein is required for inhibition of insulin signaling and regulates glial-dependent neuroblast reactivation in the developing brain. in Brain research 2012
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Bat Polyclonal FMR1 Primary Antibody für WB - ABIN6746187
Anderson, Teutsch, Dong, Wortis: An essential role for Bruton's [corrected] tyrosine kinase in the regulation of B-cell apoptosis. in Proceedings of the National Academy of Sciences of the United States of America 1996
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Human Polyclonal FMR1 Primary Antibody für ELISA, IHC (p) - ABIN451678
Hanson, Blank, Valenzuela, Garner, Madison: The functional nature of synaptic circuitry is altered in area CA3 of the hippocampus in a mouse model of Down's syndrome. in The Journal of physiology 2007
Human Monoclonal FMR1 Primary Antibody für ELISA, WB - ABIN515777
Schutzius, Bleckmann, Kapps-Fouthier, di Giorgio, Gerhartz, Weiss: A quantitative homogeneous assay for fragile X mental retardation 1 protein. in Journal of neurodevelopmental disorders 2013
Polyclonal FMR1 Primary Antibody für ELISA, WB - ABIN539767
Sittler, Devys, Weber, Mandel: Alternative splicing of exon 14 determines nuclear or cytoplasmic localisation of fmr1 protein isoforms. in Human molecular genetics 1996
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Human Polyclonal FMR1 Primary Antibody für ELISA, WB - ABIN542454
Dölen, Osterweil, Rao, Smith, Auerbach, Chattarji, Bear: Correction of fragile X syndrome in mice. in Neuron 2007
Human Polyclonal FMR1 Primary Antibody für ELISA, WB - ABIN560935
Tucker, Richards, Lardelli: Contribution of mGluR and Fmr1 functional pathways to neurite morphogenesis, craniofacial development and fragile X syndrome. in Human molecular genetics 2006
Human Monoclonal FMR1 Primary Antibody für IF, IHC - ABIN966157
Dobson, Kube, Timmerman, Krushel: Identifying intrinsic and extrinsic determinants that regulate internal initiation of translation mediated by the FMR1 5' leader. in BMC molecular biology 2008
Chlamydomonas reinhardtii (C. reinhardtii) Polyclonal FMR1 Primary Antibody für WB - ABIN1720852
Subramanian, Dubini, Astling, Laurens, Old, Grossman, Posewitz, Seibert: Profiling Chlamydomonas metabolism under dark, anoxic H2-producing conditions using a combined proteomic, transcriptomic, and metabolomic approach. in Journal of proteome research 2014
suggest that miR-219 regulates dFMR1 expression in Drosophila and is involved in fragile X syndrome pathogenesis
Authors demonstrate that under supersaturating conditions, dfmr1 mutant mitochondria have significantly increased maximum electron transport system (ETS) capacity.
Stored oocytes lacking FMR1 usually generate embryos with severe neural defects, unlike stored wild-type oocytes, which suggests that translation of multiple large proteins by stored mRNAs is defective in fragile X syndrome and possibly other autism spectrum disorders.
This FMRP activity is mediated solely via a second conserved RNA-binding protein, LIN-28, known to boost insulin signaling in stem cells. Via LIN-28, FMRP controls progenitor cell behavior by post-transcriptionally repressing the level of insulin receptor (InR).
DTor and DFMRP immunoreactivities were partially colocalized in several cellular organelles in larval muscles
Synaptic release of neuropeptides and neurotrophins depends on presynaptic accumulation of dense-core vesicles (DCVs). At rest, DCVs are captured bidirectionally as they circulate through Drosophila motoneuron terminals by anterograde and retrograde transport. Here we show that activity stimulates further synaptic capture that is distinguished from basal capture by its selectivity for anterograde DCVs and its inhibition b
Fmr1 protein associates with ninaE mRNA and represses its translation.
Our data strongly support a gain-of-function pathogenic mechanism of PQBP1 c.459_462delAGAG and c.463_464dupAG mutations, and suggest that therapeutic strategies to restore FMRP function may be beneficial for those patients
dFMRP cooperates with Piwi in maintaining genome integrity by silencing heterochromatic genes and suppressing transposon expression.
results show Fragile X Mental Retardation Protein (FMRP) shapes neuron class-specific calcium signaling in excitatory vs. inhibitory neurons in developing learning/memory circuitry, and that FMRP mediates activity-dependent regulation of calcium signaling specifically during the early-use critical period.
results support a model whereby dFMRP can modulate the neurotoxicity caused by TDP-43 overexpression
demonstrate that Zfrp8 genetically interacts with Fmr1 and tral in an antagonistic manner. Zfrp8 and FMRP both control heterochromatin packaging, also in opposite ways
dFmr1 protein is essential for proper cardiac function and establish the fly as a new model for studying the role(s) of FraX proteins in the heart.
Driving expression of FMRpolyG enhanced induction of UPS impairment in cell models, while prevention of RAN translation attenuated UPS impairment in cells and suppressed the genetic interaction with UPS manipulation in Drosophila
These results show that dfmr1 acts in a neuron type-specific activity-dependent manner for sculpting dendritic arbors during early-use, critical period development of learning and memory circuitry in the Drosophila brain.
upon the stimulation of replication stress, dFMR1 is associated with chromatin in a domain-specific manner, which is essential for its ability to induce the phosphorylation of H2Av.
The results of this study show that GABAergic circuit structure and function are impaired in the FXS disease state
FMRP inhibits translation by binding directly to the L5 protein on the 80S ribosome.
FMRP negatively regulates HSPG co-receptors controlling trans-synaptic signaling during synaptogenesis
FMRP and Ataxin-2 have roles in long-term olfactory habituation and neuronal translational control
our study provides one of the largest case control studies. Based on the screening of FMR1 CGG repeats in 15 626 patients, the results of this study do not support the implication of the IA in the appearance of MD, POI or NDD considering the current range of 45-55CGGs
These findings underscore the modulatory roles of FMRP in human neurogenesis, and further demonstrate that the defective phenotype of FXS could be reversed at least partly by small molecule kinase inhibitors.
a robust functional impairment caused by FMR1 mutations that might contribute to neuronal dysfunction in Fragile X syndrome, is reported.
FMRP is an RNA-binding protein that also interacts with numerous cytoplasmic and nuclear proteins.
Screening for CGG repeat expansion mutation in FMR1 should be recommended to the women with the history of spontaneous abortion or induced abortion due to delayed growth of the embryos
Clinical presentation, epidemiology and molecular background FMR1-dependent diseases ([Fragile X syndrome [FXS], fragile X-associated primary ovarian insufficiency [FXPOI], fragile X-associated tremor/ataxia syndrome [FXTAS]) are reviewed.
These results show developmental effects of increased calcium influx via L-type Cav channels in fragile X syndrome neural progenitors.
This study demonstrated that the FMR1 gray zone alleles are a significant risk factor for parkinsonism in females.
Clinical involvement in men and women carrying the FMR1 premutation currently constitutes a real health problem in the society that should be taken into account. It is important to highlight that while in FXS there is a loss-of-function of the FMR1 gene, in premutation associated disorders there is a gain of FMR1 mRNA function
Bioinformatic analysis of the protein networks implies potentially novel functions for beta-catenin, particularly in mRNA translation, and we confirm a direct interaction between beta-catenin and the fragile X mental retardation protein (FMRP).
Various CGG expansions of the FMR1 allele may lead to changes of RNA levels and ratios of distinct FMRP RNA isoforms, which could regulate the translation and/or cellular localization of FMRP, affect the expression of steroidogenic enzymes and hormonal receptors, or act in some other epigenetic process and therefore result in the ovarian dysfunction in infertility.
FMR1 pan-ethnic premutation Fragile X syndrome carrier frequency was 1 in 20.
These data do not support the causative link between premutationand "gray zone" expansions (of the FMR1 gene )and developmental-delay phenotypes in pediatric settings
This is the first study to establish a stem cell model aimed to understand FMR1 CGG repeat instability amongst female premutation carriers
fragile X mental retardation protein (FMRP) as a ZIKV subgenomic flaviviral RNA-binding protein and confirmed this interaction in cultured cells and mouse testes.
Our study thus takes one more step toward the identification of dynamic, unconventional DNA structures across the G-rich repeats at FMR1 and C9orf72 disease-associated loci.
Combining genetic knockdown of GKAP and pharmacological inhibition of NMDAR, study implicates FMRP and HSF1 as downstream effectors, which along with GKAP demonstrably support invasiveness of PanNET and pancreatic ductal adenocarcinoma cancer cells.
We measured the rate of protein synthesis in fibroblasts derived from 32 individuals with Fragile X syndrome (FXS) and from 17 controls as well as in fibroblasts and primary neurons of 27 Fmr1 KO mice and 20 controls. Here, we show that levels of protein synthesis are increased in fibroblasts of individuals with FXS and Fmr1 KO mice
Results provide evidence that the developmental delay is the cumulative result of a methylated FMR1 full mutation on the active X-chromosome and the inactivation of the other homologue carrying de novo 439 kb deletion.
At the molecular level, Fragile X-associated tremor/ataxia syndrome is characterized by increased expression of FMR1 sense and antisense RNA containing expanded CGG or GGC repeats, respectively
We identified thousands of clustered RNA editing sites in the zebrafish transcriptome and showed that Fmrp biochemically interacts with the Adar2a protein. The expression levels of the adar genes and Adar2 protein increased in fmr1-/- zebrafish
Loss-of-function fmr1 mutants carrying an anti-fmr1 miRNA transgene show abnormal neuronal morphology and connectivity similar to that seen in human fragile X syndrome.
translation-independent function of fragile X mental retardation protein has a major role in regulating ion-channel activity, specifically the SK channels
This study demonstrated that fmr1 knockout affect the neuronal pathway development in mice.
Study finds that Fmr1 is required for the proper development of visual circuit organization and function in the superior colliculus. Visual dysfunction is heterogeneously manifested in a subcircuit-specific manner in Fmr1-/y mice, consistent with previous studies in human fragile X syndrome patients.
A Fmr1-knockout model of Fragile X syndrome produces abnormal hippocampal theta and gamma rhythms.
Identification of mRNA targets of FMRP in the brain.
Study finds that experience-driven CA1 synaptic function and synaptic plasticity changes are excessive in Fmr1-null mice, but CA1 place fields are normal.
Data suggests mitochondrial dysfunction as a contributor to the impaired dendritic maturation of fragile X mental retardation protein (FMRP)-deficient neurons and suggest a role for interactions between FMRP and Huntingtin in the pathogenesis of fragile X syndrome.
This study show that the mossy fiber synapse is altered during development in the FXS mouse model.
These data together suggest that FMRP regulates the stability of its m6A-marked mRNA targets through YTHDF2, which could potentially contribute to the molecular pathogenesis of Fragile X syndrome.
indicate a small but significant change in the average spine volume and more eminent differences in the statistical distribution in Fmr1 knock-out mice even in adulthood, which reflects the abnormal in vivo dynamics of spine volumes
FMRP controls diverse transcriptional and posttranscriptional gene expression programs critical for neural differentiation.
This study demonstrated that the time course of development of inhibition onto Adult Born Dentate Granule Neurons is altered in Fmr1 KO mice.
We found that the impaired homeostatic synaptic downscaling in Fmr1 KO neurons is caused by loss-of-function dephosphorylation of an epilepsy-associated ubiquitin E3 ligase, neural precursor cell expressed developmentally down-regulated gene 4-2, Nedd4-2. Such dephosphorylation of Nedd4-2 is surprisingly caused by abnormally stable tumor suppressor p53 and subsequently destabilized kinase Akt.
as deficits in social behaviors seem to occur independently from each other in FMRP and Slack null mutants, we conclude that Slack is not involved in the autistic phenotype of FMRP KO mice.
loss of FMRP leads to the abnormal function and localization of kainite receptors.
Study in mouse model of fragile X syndrome reveals a role for FMRP and histone acetylation in cognition. The loss of FMRP resulted in elevated protein synthesis of histone acetyltransferase EP300 and downregulation of histone deacetylase HDAC1 through ubiquitin-mediated degradation.
Interplay between FMRP and lncRNA TUG1 regulates axonal development through mediating SnoN-Ccd1 pathway
The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.
, Fragile-X mental retardation protein
, drosophila fragile X mental retardation protein
, fragile X
, fragile X mental retardation
, fragile X mental retardation 1
, fragile X mental retardation gene
, fragile X mental retardation protein
, fragile X protein
, fragile X related protein
, fragile X-related
, fragile x related
, fragile X mental retardation protein 1
, fragile X mental retardation protein 1 homolog
, fragile X mental retardation syndrome 1 homolog
, fragile X mental retardation-1 protein
, protein FMR-1
, ragile X mental retardation protein
, fragile X mental retardation 1 protein