FMR1 Antikörper (pSer499)

Produktnummer ABIN6254033

Produktdetails anti-FMR1 Antikörper

Target: FMR1 (Fragile X Mental Retardation 1 (FMR1))

Bindungsspezifität: pSer499

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FMR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Maus, Ratte (Rattus)

Homologie: bovine, canine, chicken, human, mouse, non-human primates, sheep, Xenopus, zebra fish

Aufreinigung: Antigen Affinity Purified from Pooled Serum

Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser499 conjugated to KLH

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Lagerung: -20 °C

Referenzen für anti-FMR1 Antikörper (ABIN6254033)

Bartley, OKeefe, Blice-Baum, Mihailescu, Gong, Miyares, Karaca, Bordey: "Mammalian FMRP S499 Is Phosphorylated by CK2 and Promotes Secondary Phosphorylation of FMRP." in: eNeuro, Vol. 3, Issue 6, (2017) (PubMed).

Reynolds, Smith, Jefferson, Lugo: "Comparison of Equivalence between Two Commercially Available S499-Phosphorylated FMRP Antibodies in Mice." in: PLoS ONE, Vol. 10, Issue 11, pp. e0143134, (2016) (PubMed).

Guimarães-Souza, Perche, Morgans, Duvoisin, Calaza: "Fragile X Mental Retardation Protein expression in the retina is regulated by light." in: Experimental eye research, Vol. 146, pp. 72-82, (2016) (PubMed).

Bartley, OKeefe, Bordey: "FMRP S499 is phosphorylated independent of mTORC1-S6K1 activity." in: PLoS ONE, Vol. 9, Issue 5, pp. e96956, (2015) (PubMed).

Details zu FMR1

Target: FMR1 (Fragile X Mental Retardation 1 (FMR1))

Andere Bezeichnung: FMR1 (FMR1 Produkte)

Molekulargewicht: '71 kDa

Gen-ID: 24948

UniProt: Q80WE1

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development