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Chicken Polyclonal NRF1 Primary Antibody für IHC (p), ELISA - ABIN5326807
Morrish, Giedt, Hockenbery: c-MYC apoptotic function is mediated by NRF-1 target genes. in Genes & development 2003
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Human Polyclonal NRF1 Primary Antibody für IF (p), IHC (p) - ABIN675219
Qin, Wang, Huo, Yan, Jiang, Zhou, Wang, Sang: Sulfur dioxide inhalation stimulated mitochondrial biogenesis in rat brains. in Toxicology 2012
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Mouse (Murine) Polyclonal NRF1 Primary Antibody für IHC, ELISA - ABIN129526
Joseph, Nguyen, Welter, Dominguez, Behnke, Adhihetty: Mitochondrial adaptations evoked with exercise are associated with a reduction in age-induced testicular atrophy in Fischer-344 rats. in Biogerontology 2015
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Human Polyclonal NRF1 Primary Antibody für ICC, IF - ABIN4340686
Sotgia, Whitaker-Menezes, Martinez-Outschoorn, Salem, Tsirigos, Lamb, Sneddon, Hulit, Howell, Lisanti: Mitochondria "fuel" breast cancer metabolism: fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells. in Cell cycle (Georgetown, Tex.) 2012
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Cow (Bovine) Polyclonal NRF1 Primary Antibody für IHC, WB - ABIN2775850
Teodoro, Duarte, Gomes, Varela, Peixoto, Rolo, Palmeira: Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: a possible role for SirT3 activation. in Mitochondrion 2013
Human Monoclonal NRF1 Primary Antibody für IHC (p), RNAi - ABIN2752368
Thompson, MacDonald, Mueller: Decreased expression of BRCA1 in SK-BR-3 cells is the result of aberrant activation of the GABP Beta promoter by an NRF-1-containing complex. in Molecular cancer 2011
Human Polyclonal NRF1 Primary Antibody für ICC, IHC (p) - ABIN3044020
Sun, Zhong, Zhang, Zhou: Defect of mitochondrial respiratory chain is a mechanism of ROS overproduction in a rat model of alcoholic liver disease: role of zinc deficiency. in American journal of physiology. Gastrointestinal and liver physiology 2016
By Ras via MEK/ERK/NRF1/Atg7 signaling pathways.
HBZ suppresses TDP1 expression by inhibiting NRF-1 function in Adult T-cell leukemia cells.
NRF1, an activator of mitochondrial metabolism, supports mammary spheroid survival and tumor development.
NRF1 is more stable in KEAP1(+/+) than in KEAP1(-/-) isogenic cell lines, whereas NRF2 is dramatically stabilized in KEAP1(-/-) cells.
Clinical confirmation of our machine learned Bayesian networks will have significant impact on our understanding of the role of NRF1 as a valuable biomarker for breast cancer diagnosis and prognosis as well as provide strong rationale for future studies to develop NRF1 signaling-based therapeutics to target HER2+ breast cancer.
CB-5083 decreases viability in multiple myeloma cell lines and patient-derived multiple myeloma cells, including those with background proteasome inhibitor (PI) resistance. CB-5083 has a unique mechanism of action that combines well with PIs, which is likely owing to the p97-dependent retro-translocation of the transcription factor, Nrf1, which transcribes proteasome subunit genes following exposure to a PI
Chronic kidney disease patients undergoing hemodialysis might be subjected to potential mitochondrial oxidative dysregulation and NRF1 down-regulation.
this study therefore identifies NRF-1 as a novel regulator of HIF-1a.
NRF-1 and its target mitochondrial transcription factor A (TFAM) were higher in Tamoxifen (TAM)-resistant LCC2 and LCC9 cells than TAM-sensitive MCF-7 cells.
NRF1 overexpression attenuated BPDEinduced Sphase arrest via the ATM/Chk2 signaling pathway.
Low NRF1 expression was associated lymphatic metastasis and radio-resistance in nasopharyngeal carcinoma.
EglN2 associates with the NRF1-PGC1alpha complex and controls mitochondrial function in breast cancer
Lack of aprataxin impairs mitochondrial functions via downregulation of the APE1/NRF1/NRF2 pathway.
We show that composite nucleosomes containing mH2A and NRF-1 are stably positioned on gene regulatory regions and can buffer transcriptional noise associated with antiviral responses
Results present evidence in the support of E2-induced ROS-mediated AKT signalling leading to the activation of NRF-1-regulated cell cycle genes.
This study identified a regulatory branch of the mitochondrial unfolded protein response (UPR(mt)), which is mediated by the interplay of SIRT7 and NRF1 and is coupled to cellular energy metabolism and proliferation.
The mitochondria targeting sequence-deficient hTFAM also repressed Tfam promoter activity to the same degree as hTFAM.
Low NRF1 expression is associated with chronic kidney disease after dialysis.
We verified that NRF-1 positively regulates FAM134C and ENOX1, and negatively regulates C3orf10 in human neuroblastoma IMR-32 cells and primary rat cortical neurons.
NRF-1 regulates Atp1a1 and Atp1b1 and are important in mediating the energy generation and neuronal activity.
These findings identified a negative feedback loop between miR-378 and Nrf1 that promotes the pathogenesis of hepatosteatosis
that Nrf1 and Nrf1-mediated pathways have context-dependent and cell-state-specific functions during neural development
mRNA and protein levels of Nrf1D were detected to varying extents in hemopoietic and somatic tissues. Nrf1D-derived isoforms were present in blood plasma.
Study identifies the endoplasmic reticulum (ER)-bound transcription factor nuclear factor erythroid 2 related factor-1, Nrf1/Nfe2L1, as a critical mediator of this process and shows that Nrf1 directly binds to and specifically senses cholesterol in the ER through a defined domain and that cholesterol regulates Nrf1 turnover, processing, localization, and activity.
data highlight a precise crosstalk between transcriptional regulation by NRF1 and epigenetic modulation during germ cell development and unequivocally demonstrate a novel role of NRF1 in spermatogenesis
our investigation shows that the ER membrane protein TCF11/Nrf1 is an essential component of the cellular stress response mechanism. In response to cytotoxic stress, TCF11/Nrf1 is retrotranslocated and transferred to the nucleus where it induces proteasome subunit expression via binding to the ARE region of the relevant promoter.
Nrf1 knockdown suppressed the death of ubiquitin-deficient N2a cells upon exposure to As(III). Therefore, the levels of p65-Nrf1 may play an important role in the maintenance of cell viability under oxidative stress induced by As(III).
findings suggest that neurodegeneration in Nrf1 NKO mice may stem from the dysfunction of the ubiquitin-mediated regulation of neuronal proteins
Our findings demonstrate that DEE and a fraction derived from this extract exerts anti-inflammatory effects through Nrf2dependent HO-1 expression
NRF1 (nuclear respiratory factor 1) is a methylation-sensitive transcription factor; in the absence of DNA methylation, NRF1 binds to new sites and induces aberrant transcription
Nrf1 plays critical roles in regulating glucose metabolism, mitochondrial function, and insulin secretion, suggesting that Nrf1 may be a novel target to improve the function of insulin-secreting beta-cells.
lysine-specific demethylase 1 promotes oxidative phosphorylation in white adipose tissue, in cooperation with Nrf1.
Results show that Nrf1 may not be directly responsible for the loss of Nrf2-dependent inducibility of antioxidant and cytoprotective genes observed in aged animals.
Nrf1 controls both the fatty acid and the cystine/cysteine content of hepatocytes by participating in an elaborate regulatory network.
Data indicate both Nrf1a and Nrf1b isoforms transcripts were detected in different mouse and human cell lines, and in various mouse tissues.
During fetal myogenesis, Pitx2/3 control this redox state through the regulation of Nrf1 and of antioxidant pathways.
NST-adjoining TADs are partially repartitioned out of membranes into the cyto/nucleoplasmic side, where Nrf1 is subject to deglycosylation and/or proteolysis to generate 95-kDa and 85-kDa isoforms
NRF-2 and NRF-1 operate in a concurrent and parallel manner in mediating the tight coupling between energy metabolism and neuronal activity at the molecular level.
Nrf1 binds to the antioxidant response elements (AREs) in regulatory regions of the Lipin1 and PGC-1beta genes and the binding of Nrf1 to the AREs activates reporter gene transcription.
these results clearly suggest that both beta-TrCP- and Hrd1-dependent degradation mechanisms regulate the transcriptional activity of Nrf1 to maintain cellular homeostasis.
Knockdown of Nrf1a or Nrf1b perturbed glutathione redox state in zebrafish embryo. Nrf1 alone is not essential for the response and recovery of glutathione to oxidative insults.
Data show that nuclear respiratory factor 1 (NRF1) and zinc finger and SCAN domain-containing protein 10 (ZSCAN10) binding occurred in the promoter region of diplotypes H1-H2 to regulate homeobox protein SIX1 (SIX1) transcriptional activity.
Transcription Factor A expression associated with mitochondrial biogenesis activation & high levels of NRF1 mRNA from oocyte stage onwards argue for essential function of these factors during 1st steps of bovine embryogenesis
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for 'nuclear factor (erythroid-derived 2)-like 1' which has an official symbol of NFE2L1.
, alpha palindromic-binding protein
, not really finished protein
, nuclear respiratory factor-1
, transcription factor
, nuclear respiratory factor 1