anti-CLOCK (CLOCK) Antikörper

Bezeichnung:: anti-Clock Homolog (Mouse) Antikörper (CLOCK)

Auf www.antikoerper-online.de finden Sie aktuell 119 Clock Homolog (Mouse) (CLOCK) Antikörper von 25 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen CLOCK Kits (11) und CLOCK Proteine (6) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 145 CLOCK Produkte verfügbar.

Synonyme:: 5330400M04Rik, bHLHe8, bHLHe10, CG7391, clk, clock, dClck, dclk, dCLK/JRK, dClock, Dmel\\CG7391, Jerk, jrk, KAT13D, mKIAA0334, PAS1, Xclk, XClock, zCLOCK1, zfCLOCK1

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	CLOCK	12753	O08785
	CLOCK	60447	Q9WVS9
	CLOCK	9575	O15516
Alle Spezies anzeigen Weitere Synonyme anzeigen

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anti-Mouse (Murine) CLOCK Antikörper:

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Am meisten referenzierte anti-CLOCK Antikörper

Human Polyclonal CLOCK Primary Antibody für ChIP, WB - ABIN151057 : Jin, Shearman, Weaver, Zylka, de Vries, Reppert: A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock. in Cell 1999 (PubMed)
Show all 6 Pubmed References
Human Monoclonal CLOCK Primary Antibody für ICC, ELISA - ABIN969059 : Lee, Paik, Kang, Lim, Kim: Allelic variants interaction of CLOCK gene and G-protein beta3 subunit gene with diurnal preference. in Chronobiology international 2007 (PubMed)
Show all 2 Pubmed References
Human Polyclonal CLOCK Primary Antibody für ELISA, WB - ABIN564129 : Kalamvoki, Roizman: Circadian CLOCK histone acetyl transferase localizes at ND10 nuclear bodies and enables herpes simplex virus gene expression. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)
Polyclonal CLOCK Primary Antibody für ChIP, IP - ABIN540419 : Shearman, Weaver: Photic induction of Period gene expression is reduced in Clock mutant mice. in Neuroreport 1999 (PubMed)
Show all 5 Pubmed References
Human Polyclonal CLOCK Primary Antibody für IHC - ABIN965906 : Steeves, King, Zhao, Sangoram, Du, Bowcock, Moore, Takahashi: Molecular cloning and characterization of the human CLOCK gene: expression in the suprachiasmatic nuclei. in Genomics 1999 (PubMed)
Show all 9 Pubmed References

Weitere Antikörper gegen CLOCK Interaktionspartner

Fruit Fly (Drosophila melanogaster) Clock Homolog (Mouse) (CLOCK) Interaktionspartner

experiments define the genetic architecture required to initiate circadian clock function in Drosophila, reveal mechanisms governing circadian activator stability that are conserved in perhaps all eukaryotes, and suggest that Clk, cyc (zeige COX6C Antikörper), and cry expression is sufficient to drive clock expression in naive cells
propose that the dCLK/CYC (zeige COX6C Antikörper)-controlled TTFL operates differently in subsets of pacemaker neurons, which may contribute to their specific functions
Here we demonstrate that the transcription factor CLOCKWORK ORANGE (CWO) antagonizes CLK-CYC (zeige COX6C Antikörper) E-box binding, thus enhancing the removal of CLK-CYC (zeige COX6C Antikörper) from E-boxes to maintain transcriptional repression. This process requires PER, which suggests that PER-TIM and CWO cooperate to maintain a transcriptionally repressed state by removing CLK-CYC (zeige COX6C Antikörper) from E-boxes
these results demonstrate a key role of Clk post-transcriptional control in stabilizing circadian transcription.
Our findings suggest a novel role for clock protein (zeige ARNTL Antikörper) phosphorylation in governing the relative strengths of entraining modalities by adjusting the dynamics of circadian gene expression.
These results demonstrate that CLK phosphorylation influences the circadian period by regulating CLK activity and progression through the feedback loop.
Computational dissection of CLK/CYC (zeige COX6C Antikörper) context-specific binding sites reveals sequence motifs for putative partner factors, which are predictive for individual binding sites
usp8 (zeige USP8 Antikörper) loss of function (RNAi) or expression of a dominant-negative form of the protein (USP8 (zeige USP8 Antikörper)-DN) enhances CLK/CYC (zeige COX6C Antikörper) transcriptional activity and alters fly locomotor activity rhythms
CLK has specific targets in different tissues, implying that important CLK partner proteins and/or mechanisms contribute to gene-specific and tissue-specific regulation
CTRIP destabilizes CLK protein in a PER-independent manner and helps degradation of phosphorylated PER and TIM in the morning

Zebrafish Clock Homolog (Mouse) (CLOCK) Interaktionspartner

Data suggest that Clock1a coordinates mesoderm development and primitive hematopoiesis in embryos by up-regulating Nodal-Smad3 (zeige SMAD3 Antikörper) signaling; Clock1a alterations produce embryonic defects with shortened body length, lack of ventral tail fin, or partial defect of the eyes; Clock1a activates Smad3a (zeige SMAD3 Antikörper) promoter via its E-box1 element. (Clock1a = clock circadian regulator a; Nodal = nodal modulator 1 (zeige NOMO1 Antikörper); Smad3a (zeige SMAD3 Antikörper) = SMAD (zeige SMAD1 Antikörper) family member 3a)
effect of CRY (zeige CRY2 Antikörper) in repressing transcription mediated by CLOCK-BMAL heterodimer

Mouse (Murine) Clock Homolog (Mouse) (CLOCK) Interaktionspartner

Low expression of CLOCK protein (zeige ARNTL Antikörper) is associated with kidney tumor.
PML (zeige PML Antikörper) mediates the binding of PER2 (zeige PER2 Antikörper) to BMAL1 (zeige ARNTL Antikörper) in the BMAL1 (zeige ARNTL Antikörper)/CLOCK heterodimer and is an important component in the organization of a functional clock complex in the nucleus.
Data show that CRY1 (zeige CRY1 Antikörper) binds directly to the PAS (zeige PASK Antikörper) domain core of CLOCK:BMAL1, driven primarily by interaction with the CLOCK PAS (zeige PASK Antikörper)-B domain.
CLOCK temporally gates mast cell responses to IL-33 (zeige IL33 Antikörper) via regulation of ST2 (zeige SULT2A1 Antikörper) expression. Our findings provide novel insights into IL-33 (zeige IL33 Antikörper)/mast cell-associated physiology and pathologies.
Study showed that CLOCK can interact with RANBP9 and bind with mRNAs, demonstrating that CLOCK is involved in alternative splicing in spermatogenesis. These results reveal a novel mechanism for CLOCK in spermatogenesis.
TFEB (zeige TFEB Antikörper) regulates PER3 expression via glucose-dependent effects on CLOCK/BMAL1 (zeige ARNTL Antikörper)
ASS1 (zeige ASS1 Antikörper) acetylation by CLOCK exhibits circadian oscillation in human cells and mouse liver, possibly caused by rhythmic interaction between CLOCK and ASS1 (zeige ASS1 Antikörper), leading to the circadian regulation of ASS1 (zeige ASS1 Antikörper) and ureagenesis.
Disruption of CLOCK protein (zeige ARNTL Antikörper) alters cortical circuits and leads to generation of focal epilepsy.
Development of Mineralocorticoid receptor (zeige NR3C2 Antikörper)-mediated cardiac inflammation and fibrosis is dependent on intact signaling by the circadian protein CLOCK.
Clock protein (zeige ARNTL Antikörper) role in proteasomal and autophagic BMAL1 (zeige ARNTL Antikörper) degradation and glucose homeostasis

Human Clock Homolog (Mouse) (CLOCK) Interaktionspartner

As a novel CLOCK-dependent diurnal gene, TIMP3 (zeige TIMP3 Antikörper) inhibits the expression of inflammatory cytokines that are up-regulated by UV irradiation in human keratinocytes.
Rhythmic luciferase activity from clock gene luciferase reporter cells lines was used to test the effect of p38 MAPK (zeige MAPK14 Antikörper) inhibition on clock properties as determined using the damped sine fit and Levenberg-Marquardt algorithm.Glioma treatment with p38 MAPK (zeige MAPK14 Antikörper) inhibitors may be more effective and less toxic if administered at the appropriate time of the day.
Results indicated that inhibiting the circadian gene Clock expression can reverse the cisplatin resistance of ovarian cancer SKOV3/DDP (zeige TIMM8A Antikörper) cell lines by affecting the protein expression of drug resistance genes during which autophagy plays an important role.
Low expression of CLOCK protein (zeige ARNTL Antikörper) is associated with kidney tumor.
Association between HCRTR2, ADH4,CLOCK gene polymorphisms and cluster headache was not significant in the present study.
Study found three gene variants (CLOCK-rs4864548, PEMT (zeige PEMT Antikörper)-rs936108, and GHRELIN (zeige GHRL Antikörper)-rs696217) that exhibited uncorrected gene-by-sleep duration interactions in relation to BMI z-scores in a cohort of New Zealand European children. However, no interactions were identified in percentage body fat differences. Notably, these interactions are evident without detectable effects on sleep duration.
These findings suggest that upregulation of the circadian gene hClock plays an important role in metastasis of colorectal cancer.
results of this study suggest that genetic variability in the ARNTL (zeige ARNTL Antikörper) and CLOCK genes might be associated with risk for multiple sclerosis
CLOCK rs1801260*C and PER3(4/4) influence myelination processes by regulating sleep quality and quantity.
TFEB (zeige TFEB Antikörper) regulates PER3 expression via glucose-dependent effects on CLOCK/BMAL1 (zeige ARNTL Antikörper)

Xenopus laevis Clock Homolog (Mouse) (CLOCK) Interaktionspartner

the second half of the photolyase homology region (PHR) of CRY (zeige CRY2 Antikörper) is important for repression through facilitating interaction with CLOCK

CLOCK Antigen-Profil

Beschreibung des Gens

This gene product regulates circadian rhythm and metabolism. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and a DNA binding histone acetyltransferase. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with CLOCK

Clock (Clk) Antikörper
clock circadian regulator (CLOCK) Antikörper
clock homolog (mouse) (CLOCK) Antikörper
clock circadian regulator (clock) Antikörper
clock circadian regulator a (clocka) Antikörper
circadian locomotor output cycles kaput (Clock) Antikörper
clock circadian regulator (Clock) Antikörper
clock circadian regulator L homeolog (clock.L) Antikörper

5330400M04Rik Antikörper
bHLHe8 Antikörper
bHLHe10 Antikörper
CG7391 Antikörper
clk Antikörper
clock Antikörper
dClck Antikörper
dclk Antikörper
dCLK/JRK Antikörper
dClock Antikörper
Dmel\\CG7391 Antikörper
Jerk Antikörper
jrk Antikörper
KAT13D Antikörper
mKIAA0334 Antikörper
PAS1 Antikörper
Xclk Antikörper
XClock Antikörper
zCLOCK1 Antikörper
zfCLOCK1 Antikörper

Bezeichner auf Proteinebene für CLOCK

, , , , , , , , , , , , , , , , , , , , , , , , CG7391-PA CG7391-PD CG7391-PF CG7391-PG CG7391-PH CLOCK Clk-PA Clk-PD Clk-PF Clk-PG Clk-PH clock dClock clock homolog (mouse) clock homolog circadian locomoter output cycles protein kaput circadian locomoter output cycles protein kaput-like Clock1a clk1 circadian locomoter output cycles kaput mCLOCK rCLOCK circadian locomoter output cycles kaput protein class E basic helix-loop-helix protein 8 circadian rhythmicity protein CLOCK

GENE ID	SPEZIES
38872	Drosophila melanogaster
461312	Pan troglodytes
475145	Canis lupus familiaris
786637	Bos taurus
100008576	Meleagris gallopavo
100017022	Monodelphis domestica
100034166	Equus caballus
100038163	Xenopus (Silurana) tropicalis
100171391	Ovis aries
100172630	Pongo abelii
100349684	Oryctolagus cuniculus
100407407	Callithrix jacchus
30140	Danio rerio
100606130	Nomascus leucogenys
100628097	Sus scrofa
12753	Mus musculus
60447	Rattus norvegicus
9575	Homo sapiens
399157	Xenopus laevis
373991	Gallus gallus

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Show all anti-Clock Homolog (Mouse) (CLOCK) Antikörper with Pubmed References