CLOCK Antikörper (AA 241-290)

Produktnummer ABIN1533501

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CLOCK in WB, IHC, ELISA und IF. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für CLOCK Antikörper (AA 241-290) (ABIN1533501)

Target: CLOCK (Clock Homolog (Mouse) (CLOCK))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CLOCK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-CLOCK Antikörper

Bindungsspezifität: AA 241-290

Verwendungszweck: Clock Antibody

Spezifität: Clock Polyclonal Antibody detects endogenous levels of Clock protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human Clock. AA range:241-290

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu CLOCK

Target: CLOCK (Clock Homolog (Mouse) (CLOCK))

Andere Bezeichnung: Clock

Hintergrund:

Synonyms: CLOCK, BHLHE8, KIAA0334, Circadian locomoter output cycles protein kaput, hCLOCK, Class E basic helix-loop-helix protein 8, bHLHe8

Background: The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],

Gene Name: CLOCK

Protein Name: Circadian locomoter output cycles protein kaput

Molekulargewicht: 95 kDa

Gen-ID: 9575

OMIM: 601851

UniProt: O15516

Pathways: Regulation of Lipid Metabolism by PPARalpha, Photoperiodism