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Human Polyclonal Acsl1 Primary Antibody für WB - ABIN1881044
Phillips, Goumidi, Bertrais, Field, Cupples, Ordovas, Defoort, Lovegrove, Drevon, Gibney, Blaak, Kiec-Wilk, Karlstrom, Lopez-Miranda, McManus, Hercberg, Lairon, Planells, Roche: Gene-nutrient interactions with dietary fat modulate the association between genetic variation of the ACSL1 gene and metabolic syndrome. in Journal of lipid research 2010
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Human Monoclonal Acsl1 Primary Antibody für ELISA, WB - ABIN515508
Sandoval, Fraisl, Arias-Barrau, Dirusso, Singer, Sealls, Black: Fatty acid transport and activation and the expression patterns of genes involved in fatty acid trafficking. in Archives of biochemistry and biophysics 2008
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Human Polyclonal Acsl1 Primary Antibody für ICC, IF - ABIN314171
Fernando, Wiktorowicz, Soman, Kaphalia, Khan, Shakeel Ansari: Liver proteomics in progressive alcoholic steatosis. in Toxicology and applied pharmacology 2013
Cow (Bovine) Polyclonal Acsl1 Primary Antibody für IHC, WB - ABIN2777590
Ghosh, Barbosa, Singh: Molecular cloning and sequencing of human palmitoyl-CoA ligase and its tissue specific expression. in Molecular and cellular biochemistry 1996
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Cow (Bovine) Polyclonal Acsl1 Primary Antibody für IHC, WB - ABIN2777591
Soupene, Kuypers: Multiple erythroid isoforms of human long-chain acyl-CoA synthetases are produced by switch of the fatty acid gate domains. in BMC molecular biology 2006
Study identified a genetic variant in the 3'-UTR (zeige UTS2R Antikörper) region of ACSL1 gene (rs8086) that may play a significant role in predicting outcomes of stage II/III patients with colon cancer, so that patients with T/T genotype had a significantly higher risk of tumor recurrence than those carrying at least one C allele.
The mRNA levels of ACSL1 were positively associated with those of HBXIP (zeige HBXIP Antikörper) in clinical breast cancer tissues. Thus, we conclude that the oncoprotein HBXIP (zeige HBXIP Antikörper) is able to up-regulate ACSL1 through activating the transcriptional factor Sp1 (zeige PSG1 Antikörper) in breast cancer.
evidence in humans of ACSL1 SNPs associated with fasting glucose, diabetes, and subclinical atherosclerosis
SRE motif in ACSL1 is essential for SREBP2 (zeige SREBF2 Antikörper)-mediated activation of C-ACSL1 gene transcription.
ACSL1 is a programmable mediator of insulin (zeige INS Antikörper) sensitivity and cellular lipid content.
the cell surface protein (zeige CD28 Antikörper) CD36 (zeige CD36 Antikörper)/FAT directly facilitates fatty acid transport across the plasma membrane, whereas the intracellular acyl-CoA (zeige GNPAT Antikörper) synthetases FATP4 (zeige SLC27A4 Antikörper) and ACSL1 enhance fatty acid uptake indirectly by metabolic trapping
Data indicate that expression of miR-205 is negatively related to that of ACSL1 in clinical hepatocellular carcinoma (HCC) tissues.
INSR rs1366600, ACSL1 rs2292899 and FABP2 rs11724758 could influence the susceptibility to type 2 diabetes in Chinese Han population, most likely through their effects on the specific miRNA-binding sites.
long-chain acyl-CoA synthetase 1 has a role in eicosapentaenoic acid suppression of palmitate-induced cytokine production
Findings suggest that the ACSL1 gene polymorphism rs6552828 is not associated with elite endurance athletic status in Caucasians, yet a marginal association seems to exist for the Chinese (Han) male population.
The pig ACSL1 gene expresses differently in different tissues and pig breeds.
Authors have sequenced 3,013 bp of the pig acyl coenzyme A (zeige SOAT1 Antikörper) long-chain synthetase 1 (ACSL1) gene.
The initial QTL analysis suggested the ACSL1 gene as a candidate gene for fatty acid composition in bovine skeletal muscle; subsequent analyses indicate that ACSL1 or a gene in close proximity plays a functional role in the lipid composition of beef.
The results of this study suggest that suggest that SLC27A6 (zeige SLC27A6 Antikörper), ACSL1, FABP3 (zeige FABP3 Antikörper), AGPAT6 (zeige AGPAT6 Antikörper), and LPIN1 (zeige LPIN1 Antikörper) coordinately regulate the channeling of fatty acids toward copious milk fat synthesis in bovine mammary.
ACSL1-mediated metabolic trapping of exogenous LCFA accelerates LCFA uptake rates, albeit to a lesser extent in females, which distinctly affects LCFA trafficking to acyl intermediates but not triglyceride storage or mitochondrial oxidation and is affected by female sex hormones.
Data (including data from studies in cell line from knockout mice) suggest high incorporation of long-chain fatty acids, partly mediated by Acsl1, plays role in supply of octanoic acid for ghrelin (zeige GHRL Antikörper) acylation/lipoylation in ghrelin (zeige GHRL Antikörper)-producing cells.
Acyl-CoA synthetase 1 deficiency alters cardiolipin species and impairs mitochondrial function
long-chain acyl-CoA synthetase (zeige Acsl3 Antikörper) isoform 1 (ACSL1) deficiency in the heart activated mTORC1, thereby inhibiting autophagy and increasing the number of damaged mitochondria.
Acsl1(M-/-) mice were more insulin (zeige INS Antikörper) sensitive, and, during an overnight fast, their respiratory exchange ratio was higher, indicating greater glucose use and during endurance exercise, Acsl1(M-/-) mice ran only 48% as far as controls.
These data indicate that Acsl1-deficiency causes diastolic dysfunction and that mTOR (zeige FRAP1 Antikörper) activation is linked to the development of cardiac hypertrophy in Acsl1(H-/-) mice.
Data indicate that the expression levels of ACSL1 and its metabolite triglyceride levels were remarkably increased in hepatitis B virus X protein (HBx)-induced liver cancer tissues from the HBx transgenic mice model.
Increases understanding of the role of ACSL1 in monocytes/macrophages in inflammation and diabetes-accelerated atherosclerosis offers hope for new treatment to combat diabetic vascular disease[review]
Acyl-CoA synthetase 1 is induced by Gram-negative bacteria and lipopolysaccharide and is required for phospholipid turnover in stimulated macrophages
The combined inactivation of LACS1 and LACS4 (zeige ACSL4 Antikörper) in Arabidopsis resulted in conditional pollen sterility and impaired wax biosynthesis.
LACS1 is localized in the ER and functionally overlaps with LACS9 to supply acyl-CoAs for TAG biosynthesis.
Both ABA and LRD2 control root system architecture in the presence or absence of osmotic stress in A. thaliana. [LRD2]
lacs1 lacs2 double-mutant plants displayed pleiotropic phenotypes including organ fusion, abnormal flower development and reduced seed set.
LACS1 is a functionally novel acyl-CoA synthetase that preferentially modifies both VLCFAs for wax synthesis and long-chain (C16) fatty acids for cutin synthesis.
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation.
, LACS 2
, acyl-CoA synthetase 1
, fatty-acid-Coenzyme A ligase, long-chain 1
, fatty-acid-Coenzyme A ligase, long-chain 2
, lignoceroyl-CoA synthase
, long-chain acyl-CoA synthetase 1
, long-chain acyl-CoA synthetase 2
, long-chain fatty acid-CoA ligase 2
, long-chain fatty-acid-coenzyme A ligase 1
, long-chain-fatty-acid--CoA ligase 1
, palmitoyl-CoA ligase 1
, palmitoyl-CoA ligase 2
, paltimoyl-CoA ligase 1
, acetate-CoA ligase
, acetyl-CoA synthetase
, acetyl-Coenzyme A synthetase 1 (ADP forming)
, fatty acid Coenzyme A ligase, long chain 2
, Acyl CoA synthetase, long chain
, long-chain-fatty-acid--CoA ligase, liver isozyme
, acyl coenzyme A synthetase long-chain 1
, fatty acid coenzyme A ligase long-chain 2
, palmitoyl-CoA ligase