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anti-Human F2RL1 Antikörper:
anti-Mouse (Murine) F2RL1 Antikörper:
anti-Rat (Rattus) F2RL1 Antikörper:
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Human Monoclonal F2RL1 Primary Antibody für FACS - ABIN4898819
Amiable, Tat, Lajeunesse, Duval, Pelletier, Martel-Pelletier, Boileau: Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts. in Bone 2009
Show all 2 Pubmed References
Dog (Canine) Polyclonal F2RL1 Primary Antibody für WB - ABIN2788314
Yau, Liu, Fairlie: Toward drugs for protease-activated receptor 2 (PAR2). in Journal of medicinal chemistry 2013
plays a direct role in melanogenesis by increasing stem cell factor (zeige KITLG Antikörper) secretion from keratinocytes
Neutrophil elastase (zeige ELANE Antikörper) enhances IL-12p40 production by lipopolysaccharide-stimulated macrophages via transactivation of the PAR-2/EGFR (zeige EGFR Antikörper)/TLR4 (zeige TLR4 Antikörper) signaling pathway
PAR2 is crucial for TGF-beta1 (zeige TGFB1 Antikörper)-induced cell motility by its ability to sustain expression of ALK5 (zeige TGFBR1 Antikörper). Therapeutically targeting PAR2 may thus be a promising approach in preventing TGF-beta (zeige TGFB1 Antikörper)-dependent driven metastatic dissemination in PDAC and possibly other stroma-rich tumour types.
Protease-activated receptor 2 (PAR2) is present in human skin.
PAR2 signaling promotes cancer cell migration through miR (zeige MLXIP Antikörper)-205/BMPR1B (zeige BMPR1B Antikörper) pathway in human colorectal carcinoma.
findings showed in intestinal epithelial cells that PAR-2 activation leads to polarized IL-8 (zeige IL8 Antikörper) secretion in accordance with the side of PAR-2 activation, apical or basolateral, but do not affect ubiquitin proteasome system; demonstrate that PAR-2 activation leads to an increased IL-8 (zeige IL8 Antikörper) production and can affect proteasome system, particularly when PAR-2 activation was induced in the apical side
TF-induced microvessel stabilization is regulated via PAR2-SMAD3 (zeige SMAD3 Antikörper) that is indispensable for the maintenance of vascular integrity.
PAR-2- and PAR-1 (zeige MARK2 Antikörper)-mediated TNF-alpha (zeige TNF Antikörper) release from monocytes suggests that these unique protease receptors are involved in the pathogenesis of inflammation.
Results indicate that chymotrypsin-like serine protease (zeige F2 Antikörper) enhances soluble fms-like tyrosine kinase 1 (zeige FLT1 Antikörper) production through protease-activated receptor-2 in trophoblast cells and thus plays an important additional role in preeclampsia pathogenesis.
crystal structures of PAR2 in complex with two distinct antagonists and a blocking antibody
thrombin (zeige F2 Antikörper) is increased in a mouse model of cancer cachexia in a partially interleukin-6 (zeige IL6 Antikörper) dependent manner
Data show that activated protein C (zeige PROC Antikörper) signals via protease activated receptors PAR2/PAR3 (zeige F2RL2 Antikörper) to expand Treg cells, mitigating the disease in mice.
PAR2 plays an important and previously unrecognised anti-apoptotic role in T cell development
thrombin (zeige F2 Antikörper) has a role in diet-induced obesity through fibrin-driven inflammation
PAR2 modulation was sufficient to induce islet cell transdifferentiation in the absence of beta-cells.
Our results are suggestive that PAR2 inhibition may play a role in the treatment of diseases with increased inflammatory responses in renal systems
PAR2/GSK3beta is a novel pathway that plays a critical role in the regulation of stem/progenitor cell survival and proliferation in normal colon crypts and colon cancer.
Enhanced FXa (zeige F10 Antikörper) and PAR2 exacerbate DN and that both are promising targets for preventing diabetic nephropathy.
PAR2 is critically important in the pathogenesis of adenine-induced tubular injury
The levels of miR (zeige MLXIP Antikörper)-223, miR (zeige MLXIP Antikörper)-339 and miR (zeige MLXIP Antikörper)-21, which are associated with platelet activation, were elevated in pooled mouse plasma exosomes before thrombosis and enriched in thrombin (zeige F2 Antikörper)-stimulated platelet-derived exosomes in vitro.
PAR1 (zeige F2R Antikörper) and PAR2 regulate endothelial NO synthase (zeige NOS Antikörper) phosphorylation and activity through G(12/13) and G(q), delineating the signaling pathways by which the proteases act on protease-activated receptors to modulate endothelial functions.
Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence.
Proteinase-activated receptor 2
, G-protein coupled receptor 11
, coagulation factor II receptor-like 1
, protease-activated receptor 2
, proteinase-activated receptor 2
, thrombin receptor-like 1
, Protease-activated receptor-2
, proteinase-activated receptor-2
, Proteinase-activated receptor-2 G protein-coupled receptor 11
, Proteinase-activated receptor-2, G protein-coupled receptor 11