anti-F2RL1 (F2RL1) Antikörper

Human Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1) Interaktionspartner

1. plays a direct role in melanogenesis by increasing stem cell factor (zeige KITLG Antikörper) secretion from keratinocytes

2. Neutrophil elastase (zeige ELANE Antikörper) enhances IL-12p40 production by lipopolysaccharide-stimulated macrophages via transactivation of the PAR-2/EGFR (zeige EGFR Antikörper)/TLR4 (zeige TLR4 Antikörper) signaling pathway

3. PAR2 is crucial for TGF-beta1 (zeige TGFB1 Antikörper)-induced cell motility by its ability to sustain expression of ALK5 (zeige TGFBR1 Antikörper). Therapeutically targeting PAR2 may thus be a promising approach in preventing TGF-beta (zeige TGFB1 Antikörper)-dependent driven metastatic dissemination in PDAC and possibly other stroma-rich tumour types.

4. Protease-activated receptor 2 (PAR2) is present in human skin.

5. PAR2 signaling promotes cancer cell migration through miR (zeige MLXIP Antikörper)-205/BMPR1B (zeige BMPR1B Antikörper) pathway in human colorectal carcinoma.

6. findings showed in intestinal epithelial cells that PAR-2 activation leads to polarized IL-8 (zeige IL8 Antikörper) secretion in accordance with the side of PAR-2 activation, apical or basolateral, but do not affect ubiquitin proteasome system; demonstrate that PAR-2 activation leads to an increased IL-8 (zeige IL8 Antikörper) production and can affect proteasome system, particularly when PAR-2 activation was induced in the apical side

7. TF-induced microvessel stabilization is regulated via PAR2-SMAD3 (zeige SMAD3 Antikörper) that is indispensable for the maintenance of vascular integrity.

8. PAR-2- and PAR-1 (zeige MARK2 Antikörper)-mediated TNF-alpha (zeige TNF Antikörper) release from monocytes suggests that these unique protease receptors are involved in the pathogenesis of inflammation.

9. Results indicate that chymotrypsin-like serine protease (zeige F2 Antikörper) enhances soluble fms-like tyrosine kinase 1 (zeige FLT1 Antikörper) production through protease-activated receptor-2 in trophoblast cells and thus plays an important additional role in preeclampsia pathogenesis.

10. crystal structures of PAR2 in complex with two distinct antagonists and a blocking antibody

Mouse (Murine) Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1) Interaktionspartner

1. thrombin (zeige F2 Antikörper) is increased in a mouse model of cancer cachexia in a partially interleukin-6 (zeige IL6 Antikörper) dependent manner

2. Data show that activated protein C (zeige PROC Antikörper) signals via protease activated receptors PAR2/PAR3 (zeige F2RL2 Antikörper) to expand Treg cells, mitigating the disease in mice.

3. PAR2 plays an important and previously unrecognised anti-apoptotic role in T cell development

4. thrombin (zeige F2 Antikörper) has a role in diet-induced obesity through fibrin-driven inflammation

5. PAR2 modulation was sufficient to induce islet cell transdifferentiation in the absence of beta-cells.

6. Our results are suggestive that PAR2 inhibition may play a role in the treatment of diseases with increased inflammatory responses in renal systems

7. PAR2/GSK3beta is a novel pathway that plays a critical role in the regulation of stem/progenitor cell survival and proliferation in normal colon crypts and colon cancer.

8. Enhanced FXa (zeige F10 Antikörper) and PAR2 exacerbate DN and that both are promising targets for preventing diabetic nephropathy.

9. PAR2 is critically important in the pathogenesis of adenine-induced tubular injury

10. The levels of miR (zeige MLXIP Antikörper)-223, miR (zeige MLXIP Antikörper)-339 and miR (zeige MLXIP Antikörper)-21, which are associated with platelet activation, were elevated in pooled mouse plasma exosomes before thrombosis and enriched in thrombin (zeige F2 Antikörper)-stimulated platelet-derived exosomes in vitro.

Cow (Bovine) Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1) Interaktionspartner

1. PAR1 (zeige F2R Antikörper) and PAR2 regulate endothelial NO synthase (zeige NOS Antikörper) phosphorylation and activity through G(12/13) and G(q), delineating the signaling pathways by which the proteases act on protease-activated receptors to modulate endothelial functions.