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anti-Human F2RL1 Antikörper:
anti-Mouse (Murine) F2RL1 Antikörper:
anti-Rat (Rattus) F2RL1 Antikörper:
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Human Monoclonal F2RL1 Primary Antibody für FACS - ABIN4898819
Amiable, Tat, Lajeunesse, Duval, Pelletier, Martel-Pelletier, Boileau: Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts. in Bone 2009
Show all 2 Pubmed References
Dog (Canine) Polyclonal F2RL1 Primary Antibody für WB - ABIN2788314
Yau, Liu, Fairlie: Toward drugs for protease-activated receptor 2 (PAR2). in Journal of medicinal chemistry 2013
PAR2 signaling promotes cancer cell migration through miR (zeige MLXIP Antikörper)-205/BMPR1B (zeige BMPR1B Antikörper) pathway in human colorectal carcinoma.
findings showed in intestinal epithelial cells that PAR-2 activation leads to polarized IL-8 (zeige IL8 Antikörper) secretion in accordance with the side of PAR-2 activation, apical or basolateral, but do not affect ubiquitin proteasome system; demonstrate that PAR-2 activation leads to an increased IL-8 (zeige IL8 Antikörper) production and can affect proteasome system, particularly when PAR-2 activation was induced in the apical side
TF-induced microvessel stabilization is regulated via PAR2-SMAD3 (zeige SMAD3 Antikörper) that is indispensable for the maintenance of vascular integrity.
PAR-2- and PAR-1 (zeige MARK2 Antikörper)-mediated TNF-alpha (zeige TNF Antikörper) release from monocytes suggests that these unique protease receptors are involved in the pathogenesis of inflammation.
Results indicate that chymotrypsin-like serine protease (zeige F2 Antikörper) enhances soluble fms-like tyrosine kinase 1 (zeige FLT1 Antikörper) production through protease-activated receptor-2 in trophoblast cells and thus plays an important additional role in preeclampsia pathogenesis.
crystal structures of PAR2 in complex with two distinct antagonists and a blocking antibody
PAR-2 plays an important role in the progression of ovarian clear cell carcinoma.
Data suggest activation of PAR2 via FVIIA/TF signaling activates PI3K (zeige PIK3CA Antikörper)/AKT (zeige AKT1 Antikörper) signaling, inactivates GSK3b (zeige GSK3b Antikörper) signaling, leads to accumulation of beta-catenin (zeige CTNNB1 Antikörper), and promotes tumor cell migration/invasion. (PAR2 = protease-activated receptor 2; FVIIA = coagulation factor VIIa; TF = tissue factor/thromboplastin (zeige F3 Antikörper); PI3K (zeige PIK3CA Antikörper) = phosphatidylinositol 3-kinase; AKT (zeige AKT1 Antikörper) = proto-oncogene (zeige RAB1A Antikörper) protein c (zeige PROC Antikörper)-akt (zeige AKT1 Antikörper); GSK3b (zeige GSK3b Antikörper) = glycogen synthase kinase 3 beta (zeige GSK3b Antikörper))
PAR2 modulation was sufficient to induce islet cell transdifferentiation in the absence of beta-cells.
Studies provide increasing evidence that PAR2 plays a significant role in inflammatory diseases both in the periphery and in the CNS. There is a clear similarity between PAR2 expression and activation on cells of the immune system and those cell types that are proposed to play a role within the CNS, astrocytes and microglia. [review]
Data show that activated protein C (zeige PROC Antikörper) signals via protease activated receptors PAR2/PAR3 (zeige F2RL2 Antikörper) to expand Treg cells, mitigating the disease in mice.
PAR2 plays an important and previously unrecognised anti-apoptotic role in T cell development
thrombin (zeige F2 Antikörper) has a role in diet-induced obesity through fibrin-driven inflammation
Our results are suggestive that PAR2 inhibition may play a role in the treatment of diseases with increased inflammatory responses in renal systems
PAR2/GSK3beta (zeige GSK3b Antikörper) is a novel pathway that plays a critical role in the regulation of stem/progenitor cell survival and proliferation in normal colon crypts and colon cancer.
Enhanced FXa (zeige F10 Antikörper) and PAR2 exacerbate DN and that both are promising targets for preventing diabetic nephropathy.
PAR2 is critically important in the pathogenesis of adenine-induced tubular injury
The levels of miR (zeige MLXIP Antikörper)-223, miR (zeige MLXIP Antikörper)-339 and miR (zeige MLXIP Antikörper)-21, which are associated with platelet activation, were elevated in pooled mouse plasma exosomes before thrombosis and enriched in thrombin (zeige F2 Antikörper)-stimulated platelet-derived exosomes in vitro.
Neutrophil elastase (zeige ELANE Antikörper) induced acute inflammation and pain in knee joints of mice. These changes are PAR2-dependent and appear to involve activation of a p44 (zeige GTF2H4 Antikörper)/42 MAPK (zeige MAPK1 Antikörper) pathway. Blocking neutrophil elastase (zeige ELANE Antikörper), PAR2 and p44 (zeige GTF2H4 Antikörper)/42 MAPK (zeige MAPK1 Antikörper) activity can reduce inflammation and pain, suggesting their utility as therapeutic targets.
PAR1 (zeige F2R Antikörper) and PAR2 regulate endothelial NO synthase (zeige NOS Antikörper) phosphorylation and activity through G(12/13) and G(q), delineating the signaling pathways by which the proteases act on protease-activated receptors to modulate endothelial functions.
Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence.
Proteinase-activated receptor 2
, G-protein coupled receptor 11
, coagulation factor II receptor-like 1
, protease-activated receptor 2
, proteinase-activated receptor 2
, thrombin receptor-like 1
, Protease-activated receptor-2
, proteinase-activated receptor-2
, Proteinase-activated receptor-2 G protein-coupled receptor 11
, Proteinase-activated receptor-2, G protein-coupled receptor 11