SAG Proteine (SAG)

Bezeichnung:: S-Antigen, Retina and Pineal Gland (Arrestin) Proteine (SAG)

Auf www.antikoerper-online.de finden Sie aktuell 13 S-Antigen, Retina and Pineal Gland (Arrestin) (SAG) Proteine von 5 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SAG Antikörper (80) und SAG Kits (25) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 119 SAG Produkte verfügbar.

Synonyme:: A930001K18Rik, ARR, Arr1, arrestin, Irbp, MGC75721, MGC84416, RP47, S-AG, sag, sag1, SAGMR, SANTI, zgc:114197

alle Proteine anzeigen	Gen	GeneID	UniProt
	SAG	20215	P20443
	SAG	6295	P10523
	SAG	25539	P15887
Weitere Synonyme anzeigen

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Verknüpfte Pathways mit SAG Proteine

Regulation of G-Protein Coupled Receptor Protein Signaling

Weitere Produktkategorien zu SAG Protein

Weitere Proteine zu SAG Interaktionspartnern

Mouse (Murine) S-Antigen, Retina and Pineal Gland (Arrestin) (SAG) Interaktionspartner

We conclude that, in addition to their well-established roles in Meta II inactivation, Grk1 and Arr1 can modulate the kinetics of Meta III decay and rod dark adaptation in vivo.
The G-protein coupled receptor, DRD4, requires ARR1 and ARR4 for desensitization and internalization.
ARR4 modulates essential functions in high acuity vision and downstream cellular signaling pathways that are not fulfilled or substituted by the coexpression of ARR1, despite its high expression levels in all mouse cones.
crystal structure of a constitutively active form of human rhodopsin (zeige RHO Proteine) bound to a pre-activated form of the mouse visual arrestin, determined by serial femtosecond X-ray laser crystallography
Sag (zeige RNF7 Proteine) is essential for embryonic vasculogenesis and tumor angiogenesis.
SAG (zeige RNF7 Proteine) knockdown caused the accumulation of proapoptotic Bax (zeige BAX Proteine) and SARM (zeige SARM1 Proteine), imbalance of Bcl-2 (zeige BCL2 Proteine)/Bax (zeige BAX Proteine) in the mitochondria, induction of cytosolic cytochrome c (zeige CYCS Proteine) and activation of caspases, all of which led to disequilibrium between life and death of macrophages.
tetrameric visual arrestin 1 is a biomarker for retinal function in diabetic mice, assessed by MRI (zeige C7ORF49 Proteine)
The data suggest that monomeric arrestin-1 is cytotoxic and WT arrestin-1 protects rods by forming mixed oligomers with the mutant and/or competing with it for the binding to non-receptor partners.
Findings suggest a role for Bardet-Biedl syndrome 5 (BBS5) in regulating light-dependent translocation of arrestin1 (Arr1).
Visual arrestin interaction with clathrin adaptor AP-2 (zeige TFAP2A Proteine) regulates photoreceptor survival in the vertebrate retina.

Human S-Antigen, Retina and Pineal Gland (Arrestin) (SAG) Interaktionspartner

This is the first dominant-acting mutation identified in SAG (zeige DMBT1 Proteine), a founder mutation possibly originating in Mexico several centuries ago. The phenotype is clearly adRP (zeige PLIN2 Proteine) and is distinct from the previously reported phenotypes of recessive null mutations, that is, Oguchi disease and recessive RP.
Macular dysfunction can occur in Oguchi disease with the 1147delA mutation in the SAG (zeige DMBT1 Proteine) gene.
Based on their observed affinity for arrestin-1, P-opsin (zeige RHO Proteine) and inactive P-Rh very likely affect the physiological monomer-dimer-tetramer equilibrium of arrestin-1, and should therefore be taken into account when modeling photoreceptor function.
Compound heterozygosity of a nonsense R193X mutation and a heterozygous deletion of 3,224 bp encompassing exon 2 in the SAG (zeige DMBT1 Proteine) gene is the cause of Oguchi's disease in a Chinese family.
Identification of autoantibodies specific for two retinal antigens (CRALBP (zeige RLBP1 Proteine) and S-Ag) supports the concept of an autoimmunological origin of the disease.
the arrestin 1147delA, which has been known as a frequent cause of Oguchi disease, also may be related to the pathogenesis of autosomal recessive RP.
We describe a case of Oguchi disease with unusual findings caused by a putative heterozygous mutation in the SAG (zeige DMBT1 Proteine) gene.
maintenance of low levels of the active monomer is the biological role of arrestin-1 self-association
Rhodopsin (zeige RHO Proteine)-arrestin complexes alter the morphology of endosomal compartments and severely damage receptor-mediated endocytic functions in retinitis pigmentosa.
The existence of 2 novel mutations of the arrestin gene in 2 unrelated Japanese patients strongly supports the previous data that arrestin gene mutations are associated with Oguchi's disease

Cow (Bovine) S-Antigen, Retina and Pineal Gland (Arrestin) (SAG) Interaktionspartner

Conformational changes are involved in the arrestin-rhodopsin (zeige RHO Proteine) binding interface through multiple docking modes.
K2A mutations in arrestin-1, -2, and -3 significantly reduced their binding to active phosphorhodopsin.
maintenance of low levels of the active monomer is the biological role of arrestin-1 self-association
We hypothesize that, although arrestin requires at least a single Rho*P to bind the membrane, a single arrestin can actually interact with a pair of receptors
variant form of arrestin-1 binds rod outer segment membranes
Models suggest that the phosphorylated carboxy-terminal region of rhodopsin (zeige RHO Proteine), Rh(330-348), undergoes significant conformational changes and becomes structured upon binding to arrestin.
arrestin and p44 bind differently to different phosphorylated rhodopsin species and that this may be due to a structural difference between p44's and arrestin's basal states.

SAG Protein Überblick

Protein Überblick

may act as a GTP/GDP-binding protein\; may play a role in signal transduction in the retina

Alternative names and synonyms associated with SAG

S-antigen; retina and pineal gland (arrestin) (sag)
S-antigen; retina and pineal gland (arrestin) S homeolog (sag.S)
S-antigen; retina and pineal gland (arrestin) b (sagb)
S-antigen (PF10_0343)
S-antigen visual arrestin (SAG)
S-antigen; retina and pineal gland (arrestin) L homeolog (sag.L)
S-antigen, retina and pineal gland (arrestin) (Sag)
S-antigen visual arrestin (Sag)

A930001K18Rik Protein
ARR Protein
Arr1 Protein
arrestin Protein
Irbp Protein
MGC75721 Protein
MGC84416 Protein
RP47 Protein
S-AG Protein
sag Protein
sag1 Protein
SAGMR Protein
SANTI Protein
zgc:114197 Protein

Bezeichner auf Proteinebene für SAG

S-antigen; retina and pineal gland (arrestin) , -antigen; retina and pineal gland (arrestin) , Arrestin Sb , S-antigen , s-arrestin-like , S-AG , S-arrestin , retinal S-antigen , rod photoreceptor arrestin , 48 kDa protein , arrestin 1 , rod arrestin , visual arrestin 1 , retinal S-antigen (48 KDa protein) , arrestin1 , arrestin, S-antigen

GENE ID	SPEZIES
394670	Xenopus (Silurana) tropicalis
447588	Xenopus laevis
619268	Danio rerio
810500	Plasmodium falciparum 3D7
100445407	Pongo abelii
100598651	Nomascus leucogenys
398109	Xenopus laevis
20215	Mus musculus
6295	Homo sapiens
397151	Sus scrofa
280922	Bos taurus
25539	Rattus norvegicus
403906	Canis lupus familiaris
768877	Gallus gallus

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