anti-Guanylate Cyclase Activator 1A (Retina) Antikörper

Protein Überblick

This gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein encoded by this gene, guanylyl cyclase activating protein 1 (GCAP1), mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3)\; a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations\; causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia.

Alternative names and synonyms associated with Guanylate Cyclase Activator 1A (Retina) (GUCA1A)

• guanylate cyclase activator 1A (GUCA1A) Antikörper
• guanylate cyclase activator 1A (Guca1a) Antikörper
• guanylate cyclase activator 1A L homeolog (guca1a.L) Antikörper
• guanylate cyclase activator 1A (retina) (guca1a) Antikörper
• guanylate cyclase activator 1a (retina) (Guca1a) Antikörper
• Alle Gen-Bezeichnungen
• guanylate cyclase activator 1A (guca1a) Antikörper

• C6orf131 Antikörper
• COD3 Antikörper
• CORD14 Antikörper
• dJ139D8.6 Antikörper
• GC-A Antikörper
• Alle Synonyme
• GCAP Antikörper
• gcap1 Antikörper
• GUCA Antikörper
• Guca1 Antikörper
• guca1a Antikörper
• MGC84170 Antikörper
• MGC146317 Antikörper
• mGCAP1 Antikörper

Bezeichner auf Proteinebene für GUCA1A

GCAP 1 , cone dystrophy 3 , guanylate cyclase-activating protein, photoreceptor 1 , guanylin 1, retina , guanylyl cyclase-activating protein 1 , guanylate cyclase activator 1A (retina)