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anti-Mouse (Murine) ADRBK2 Antikörper:
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Human Polyclonal ADRBK2 Primary Antibody für EIA, IHC (p) - ABIN950649
Rao, Rapoport, Kim: Decreased GRK3 but not GRK2 expression in frontal cortex from bipolar disorder patients. in The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2009
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Human Polyclonal ADRBK2 Primary Antibody für WB - ABIN390986
Calabrese, Sallese, Stornaiuolo, Stuppia, Palka, De Blasi: Chromosome mapping of the human arrestin (SAG), beta-arrestin 2 (ARRB2), and beta-adrenergic receptor kinase 2 (ADRBK2) genes. in Genomics 1995
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GRK3 controls cardiac alpha1-adrenergic receptor responsiveness
Study found that GRK3 was significantly overexpressed in 162 pairs of colon cancer tissues than in the matched noncancerous mucosa. These data show that aberrant expression of GRK3 plays an important role in promoting colon cancer progression through enhanced proliferation and reduced apoptosis.
hat (zeige MGEA5 Antikörper) expression of GRK3 was down-regulated in pancreatic ductal adenocarcinoma and was an independent prognostic factor
GRK3 is a new critical activator of neuroendocrine phenotypes and mediator of CREB (zeige CREB1 Antikörper) activation in promoting neuroendocrine differentiation of prostate cancer cells.
effects of GRK3 modulation appear to be specific to chemokine (zeige CCL1 Antikörper)-mediated migration behaviors without influencing tumor cell proliferation or survival
data are consistent with the possibility that oncogenes can induce cellular stiffness via an HDAC6 (zeige HDAC6 Antikörper)-induced reorganization of the vimentin (zeige VIM Antikörper) intermediate filament network
Data indicate that CXCL12 (zeige CXCL12 Antikörper)-induced phosphorylation at CXCR4 (zeige CXCR4 Antikörper) S346/347 was mediated by GRK2/3.
In oral squamous cell carcinomas, malignant cells and surrounding tissue overexpress the ADRBK2 gene.
A reduced cortical concentration of GRK3 in schizophrenia (resembling that in aging) may result in altered G protein-dependent signaling, thus contributing to prefrontal deficits in schizophrenia.
GRK3 is a negative regulator of cell growth whose expression is preferentially reduced in glioblastoma of the classical subtype as a consequence of activity in primary gliomagenic pathways.
mRNA levels for GRK3 were inversely correlated with systolic and diastolic blood pressure (day, night and 24 h), which suggests a protective role for GRK3 in the regulation of human blood pressure
beta-arrestin 2 (zeige ARRB2 Antikörper) and GRK2 (zeige ADRBK1 Antikörper) colocalize with S1p2 (zeige S1PR2 Antikörper) in developing zebrafish embryos and depletion of GRK2 (zeige ADRBK1 Antikörper) in the S1p2 (zeige S1PR2 Antikörper) R150H miles apart zebrafish partially rescued cardia bifida.
GRK2 (zeige ADRBK1 Antikörper) and GRK5 (zeige GRK5 Antikörper) control cardiac function as well as morphogenesis during development although with different morphological outcomes.
Data suggest that a G protein-coupled receptor (zeige GPBAR1 Antikörper) kinase, perhaps GRK2 (zeige ADRBK1 Antikörper) or 3, functions as a vertebrate kinase for Smoothened (zeige SMO Antikörper), promoting Hedgehog (zeige SHH Antikörper) signal transduction during early development.
These data thus reveal a novel kinase activity-independent function for GRK and establish a role for GRK2 as a cell-cycle regulator during early embryonic development.
Fusion proteins containing the c-terminus of GPCR kinase 3 (GRK3ct) and either the fluorescent protein cerulean or Renilla luciferase bind to venus-labeled Gbetagamma dimers, resulting in Forster or bioluminescence resonance energy transfer.
The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.
adrenergic, beta, receptor kinase 2
, beta-adrenergic receptor kinase 2-like
, beta ARK2
, beta-adrenergic receptor kinase 2
, G-protein-coupled receptor kinase 3
, adrenergic receptor kinase, beta 2 (G-protein-linked receptor kinase)
, G-protein coupled receptor kinase 2/3