anti-ADRBK2 (ADRBK2) Antikörper

Mouse (Murine) Adrenergic, Beta, Receptor Kinase 2 (ADRBK2) Interaktionspartner

1. GRK3 controls cardiac alpha1-adrenergic receptor responsiveness

Human Adrenergic, Beta, Receptor Kinase 2 (ADRBK2) Interaktionspartner

1. Study found that GRK3 was significantly overexpressed in 162 pairs of colon cancer tissues than in the matched noncancerous mucosa. These data show that aberrant expression of GRK3 plays an important role in promoting colon cancer progression through enhanced proliferation and reduced apoptosis.

2. hat expression of GRK3 was down-regulated in pancreatic ductal adenocarcinoma and was an independent prognostic factor

3. GRK3 is a new critical activator of neuroendocrine phenotypes and mediator of CREB activation in promoting neuroendocrine differentiation of prostate cancer cells.

4. effects of GRK3 modulation appear to be specific to chemokine-mediated migration behaviors without influencing tumor cell proliferation or survival

5. data are consistent with the possibility that oncogenes can induce cellular stiffness via an HDAC6-induced reorganization of the vimentin intermediate filament network

6. Data indicate that CXCL12-induced phosphorylation at CXCR4 S346/347 was mediated by GRK2/3.

7. In oral squamous cell carcinomas, malignant cells and surrounding tissue overexpress the ADRBK2 gene.

8. A reduced cortical concentration of GRK3 in schizophrenia (resembling that in aging) may result in altered G protein-dependent signaling, thus contributing to prefrontal deficits in schizophrenia.

9. GRK3 is a negative regulator of cell growth whose expression is preferentially reduced in glioblastoma of the classical subtype as a consequence of activity in primary gliomagenic pathways.

10. mRNA levels for GRK3 were inversely correlated with systolic and diastolic blood pressure (day, night and 24 h), which suggests a protective role for GRK3 in the regulation of human blood pressure

11. we found no evidence of altered levels of acetylated histone H3 at the affected allele compared to the common allele

12. dysregulation in GRK3 expression alters signaling desensitization, and thereby predisposes to the development of bipolar disorder

13. the CRH-R1alpha carboxyl tail is important for regulation of receptor activity by G protein-coupled receptor kinase

14. ATP stimulation leads to GRK3 phosphorylation of P2X(7) receptor.

15. No support for a major role for GRK3 gene promoter variants in cocaine addiction.

16. Dysregulation in GRK3 expression alters signaling desensitization and thereby predisposes to the development of bipolar disease.

17. role for GRK3 in regulating CXCR4 attenuation and have provided a mechanistic link between the GRK3 pathway and the CXCR4-related WHIM(WT) disorder.

18. The G-384A variant may alter binding of Sp1/Sp4 transcription factors resulting in an increase in gene transcription and an increase in vulnerability to bipolar disorder.

Zebrafish Adrenergic, Beta, Receptor Kinase 2 (ADRBK2) Interaktionspartner

1. beta-arrestin 2 and GRK2 colocalize with S1p2 in developing zebrafish embryos and depletion of GRK2 in the S1p2 R150H miles apart zebrafish partially rescued cardia bifida.

2. GRK2 and GRK5 control cardiac function as well as morphogenesis during development although with different morphological outcomes.

3. Data suggest that a G protein-coupled receptor kinase, perhaps GRK2 or 3, functions as a vertebrate kinase for Smoothened, promoting Hedgehog signal transduction during early development.

4. These data thus reveal a novel kinase activity-independent function for GRK and establish a role for GRK2 as a cell-cycle regulator during early embryonic development.

Cow (Bovine) Adrenergic, Beta, Receptor Kinase 2 (ADRBK2) Interaktionspartner

1. Fusion proteins containing the c-terminus of GPCR kinase 3 (GRK3ct) and either the fluorescent protein cerulean or Renilla luciferase bind to venus-labeled Gbetagamma dimers, resulting in Forster or bioluminescence resonance energy transfer.