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Mouse (Murine) SEMA3A Protein expressed in Human Cells - ABIN2008081
Chadborn, Ahmed, Holt, Prinjha, Dunn, Jones, Eickholt: PTEN couples Sema3A signalling to growth cone collapse. in Journal of cell science 2006
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Our observation of a second case supports the notion that bi-allelic mutations in SEMA3A cause an autosomal recessive type of syndromic short stature.
the upregulation of SEMA3A in hepatocellular carcinoma (HCC (zeige FAM126A Proteine))cells promoted tumor growth and progression in an HCC (zeige FAM126A Proteine) mouse model. These results indicate that SEMA3A enhances CapG, galectin-3 (zeige LGALS3 Proteine), enolase 2 (zeige ENO2 Proteine) and EpCAM (zeige EPCAM Proteine) expression to promote HCC (zeige FAM126A Proteine) progression and is a potential therapeutic target for HCC (zeige FAM126A Proteine).
Sema3A as a novel regulator of airway smooth cell proliferation by suppressing Rac1, GSK-3beta and STAT3 (zeige STAT3 Proteine) signaling mediated by Nrp1 (zeige NELL1 Proteine).
Measuring electrical impedance allows real-time monitoring of changes in endothelial cell morphology and adhesion induced by SEMA3E (zeige SEMA3E Proteine) via plexin D1 (zeige PLXND1 Proteine)
describe a method where in vitro cultures of growth cones are incubated with these ligands in the presence or absence of Sema3A, followed by stripping of remaining ligand on cell-surface and analysis by immunofluorescence techniques
Semaphorin 3A increased tumor-infiltrating macrophages (TAM (zeige CCNA1 Proteine)) infiltration and promoted hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) progression. Semaphorin 3A expression alone, or combined with the number of TAMs, is a new prognostic factor and potential target for the treatment of HCC (zeige FAM126A Proteine).
Significant genetic risk for Hirschsprung disease (HSCR (zeige EDNRB Proteine)) was imparted by rs2435357 and rs2506030 at RET (zeige RET Proteine) and by rs12707682 at SEMA3 in a Chinese population. No evidence was found of a genetic association between HSCR (zeige EDNRB Proteine) and either of the NRG1 (zeige NRG1 Proteine) SNPs rs7835688 and rs16879552, at either allele or genotype level.
rs139438618 at the semaphorin 3A locus was significantly associated with Alcohol Dependence and Major Depression comorbidity in African Americans. There was no significant association identified in European American participants.
Serum level of Sema3A taken from diagnosed celiac without gluten-free diet was higher significantly than healthy controls.
Sema3A serum levels and the expression of sema3A on Tregs was significantly lower in patients with moderate to severe asthma when compared to healthy individuals.
Sema3A reduces cardiac inflammation and improves cardiac function after myocardial infarction by promoting the resolution of inflammation.
The findings highlight an active role for satellite cell-secreted Sema3A ligand as a key "commitment factor" for the slow-fiber population during muscle regeneration.
This approach can be used to study responses to repulsive guidance factors such as semaphorin 3A. Here I describe the procedures used to prepare cultured neurons for rotary-shadow EM, allowing detailed comparisons of cytoskeletal structure
Sema3a-Nrp2 (zeige NRP2 Proteine) signaling along an unrecognized pancreatic developmental axis constitutes a chemoattractant system essential for generating the hallmark morphogenetic properties of pancreatic islets.
These data suggest that both Nrp1 (zeige NRP1 Proteine) and Sema3a are expressed in the cochlea during time points when spiral ganglion cell begin to innervate the organ of Corti.
We show that PTP-3, a LAR (zeige PTPRF Proteine) homolog in Caenorhabditis elegans, participates in Sema2A-regulated axon guidance. PTPdelta, a member of vertebrate LAR (zeige PTPRF Proteine) class PTPs (zeige PTS Proteine), is involved in Sema3A-regulated cortical dendritic growth. In Sema3A signaling, PTPdelta activates Fyn (zeige FYN Proteine) and Src (zeige SRC Proteine) kinases by dephosphorylating their C-terminal Tyr (zeige TYR Proteine) residues.
Investigated the effects of BotoxA-induced paralysis on the sprouting capacity of neuromuscular junctions (NMJs) in the K108N-SEMA3A mutant, and observed no change in the differential neuronal plasticity found at NMJs on fast-fatigable or slow muscle fibers due to the presence of the SEMA3A mutant protein.
The aim was to elucidate whether ectopic muscles are a result of misguidance of myoblast precursors due to the loss of Sema3A-Npn-1 (zeige NRP1 Proteine) signaling.
These findings suggest that by interacting with PlexA4 (zeige PLXNA4 Proteine), TrkA (zeige NTRK1 Proteine) plays a crucial role in redirecting local Sema3A signaling to retrograde axonal transport, thereby regulating dendritic GluA2 (zeige GRIA2 Proteine) localization and patterning.
Findings indicate that Rho and ROCK knockout may improve the behavior of mice and prevent MPTP (zeige PTPN2 Proteine)-induced dopaminergic neurons damage by regulating Sema3A, PlexinA and NRP-1 (zeige NRP1 Proteine) in a mouse model of Parkinson's disease.
This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.
, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
, semaphorin 3A
, collapsin 1
, semaphorin D
, semaphorin III
, semaphorin L
, sema D
, sema III
, Semaphorin 3a
, sema domain, immunoglobulin domain (Ig), short basic domain, sec