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Mouse (Murine) SEMA3A Protein expressed in Human Cells - ABIN2008081
Chadborn, Ahmed, Holt, Prinjha, Dunn, Jones, Eickholt: PTEN couples Sema3A signalling to growth cone collapse. in Journal of cell science 2006
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the inhibitory effect of Sema3C (zeige SEMA3C Proteine) on microcapillary formation by human umbilical vein endothelial cells could be abrogated upon mutation at the Sema3C (zeige SEMA3C Proteine) basic domain within putative furin (zeige FURIN Proteine) cleavage site 742RNRR745, indicating that this site was essential for the Sema3 biological activity.
Results provide evidence that SEMA3A is highly expressed in glioblastoma (GBM) compared to non-neoplastic brain tissues and SEMA3A signaling axis promotes GBM growth and invasion.
these findings shows that miR (zeige MLXIP Proteine)-362 promotes lung cancer metastasis through downregulation of Sema3A
These findings indicate a regulatory mechanism and a proapoptotic function of aberrant Sema3A signaling in Osteoarthritis (OA) chondrocytes, and suggest that targeting Sema3A signaling might interfere OA pathogenesis.
increased concentrations of urinary SEMA (zeige SEMA3B Proteine)-3A and urinary Netrin-1 (zeige NTN1 Proteine) are found in urine from children with severe hydronephrosis and that their concentrations are related to the degree of obstruction.
Advanced peri (zeige PLIN1 Proteine)-implantitis lesions showed higher levels of gene expression for Sem3A and Sem4D and lower levels of Sem4A in comparison to tissues obtained from a healthy dental implant.
clinical samples from apical periodontitis patients were obtained to analyse the expression of Sema3A/Nrp1 (zeige NELL1 Proteine). These results indicated that the bone destruction level expanded from days 7 to 35
study demonstrates that Sema3E (zeige SEMA3E Proteine)/plexinD1 inhibits proliferation and migration of vascular smooth muscle cells via inactivation of Rap1 (zeige RABGEF1 Proteine)-AKT (zeige AKT1 Proteine) signalling pathways
Results showed a preferential association of NRP1 (zeige NELL1 Proteine) with SEMA3A, suggesting that SEMA3A can partially reverse the effects caused by the VEGFA (zeige VEGFA Proteine) preventing its binding with the NRP1 (zeige NELL1 Proteine) receptor.
Our observation of a second case supports the notion that bi-allelic mutations in SEMA3A cause an autosomal recessive type of syndromic short stature.
study demonstrates that Sema3E (zeige SEMA3E Proteine)/plexinD1 inhibits proliferation and migration of vascular smooth muscle cells via inactivation of Rap1 (zeige TERF2IP Proteine)-AKT (zeige AKT1 Proteine) signalling pathways
SEMA3A expression is increased in the endothelin receptor-B (zeige EDNRB Proteine) null mouse model of Hirschsprung disease, suggesting that SEMA3A may interfere with enteric neural crest cell migration, resulting in an absence of enteric neurons.
Our results demonstrated that overexpression of Sema3A in oral cancer cells drastically suppressed tumor growth by inhibiting angiogenesis.
a novel role for Sema3A-neuropilin 1 (zeige NRP1 Proteine) signalling in progenitor cell dynamics and in the generation of interneurons in the ventral telencephalon
Sema3A reduces cardiac inflammation and improves cardiac function after myocardial infarction by promoting the resolution of inflammation.
The findings highlight an active role for satellite cell-secreted Sema3A ligand as a key "commitment factor" for the slow-fiber population during muscle regeneration.
This approach can be used to study responses to repulsive guidance factors such as semaphorin 3A. Here I describe the procedures used to prepare cultured neurons for rotary-shadow EM, allowing detailed comparisons of cytoskeletal structure
Sema3a-Nrp2 (zeige NRP2 Proteine) signaling along an unrecognized pancreatic developmental axis constitutes a chemoattractant system essential for generating the hallmark morphogenetic properties of pancreatic islets.
These data suggest that both Nrp1 (zeige NRP1 Proteine) and Sema3a are expressed in the cochlea during time points when spiral ganglion cell begin to innervate the organ of Corti.
Sema3a1 is a guidance factor for neural growth cones and has a role in the development of the vascular system
Sema3a1 plays an essential role in guiding the caudal primary (CaP) motor axon that pioneers the initial region of the motor pathway.
This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.
, semaphorin D
, semaphorin III
, semaphorin L
, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
, sema D
, sema III
, Semaphorin 3a
, sema domain, immunoglobulin domain (Ig), short basic domain, sec
, semaphorin 3A
, sema Z1A
, semaphorin 1a