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anti-Human PTH1R Antikörper:
anti-Mouse (Murine) PTH1R Antikörper:
anti-Rat (Rattus) PTH1R Antikörper:
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Human Monoclonal PTH1R Primary Antibody für ICC, IHC - ABIN969372
Dean, Vilardaga, Potts, Gardella: Altered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH/PTHrP receptor. in Molecular endocrinology (Baltimore, Md.) 2007
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Cow (Bovine) Monoclonal PTH1R Primary Antibody für IHC (p), WB - ABIN444936
Madiraju, Gawri, Wang, Antoniou, Mwale: Mechanism of parathyroid hormone-mediated suppression of calcification markers in human intervertebral disc cells. in European cells & materials 2013
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It seems likely that Mut (zeige MUT Antikörper)-PTH1R may be, at least in part, co-localized with Wt-PTH1R by forming a heterodimer, leading to affect the function to each other in Jansen type metaphyseal chondrodysplasia (zeige COL11A1 Antikörper).
PTH1R mutation is associated with Primary Failure of Tooth Eruption.
Data suggest that GCGR (glucagon receptor (zeige GCGR Antikörper)) activation proceeds via a mechanism in which transmembrane helix 6 (TM6) is held in an inactive conformation by a conserved polar core and a hydrophobic lock (involving intracellular loop 3, IC3); mutations in the corresponding polar core of GCGR (zeige GCGR Antikörper) or PTH1R disrupt these inhibitory elements, allow TM6 to swing outward, and induce constitutive G protein signaling.
data highlight sequences in PTHR that contribute to NHERF1 (zeige SLC9A3R1 Antikörper) interaction and can be altered to prevent phosphorylation-mediated inhibition
Overt hypercalcemia is not always encountered in Jansen Metaphyseal Chondrodysplasia (zeige COL11A1 Antikörper) due to Heterozygous H223R-PTH1R Mutation.
data are consistent with the hypothesis that the pattern of C-terminal tail phosphorylation on PTH1R may determine the signaling outcome following receptor activation.
the data presented in this manuscript demonstrate a critical function of VPS35 (zeige vps35 Antikörper) in regulating PTH1R trafficking. This event and VPS35 (zeige vps35 Antikörper)-interaction with PPP1R14C (zeige PPP1R14C Antikörper) appear to be essential for turning off PTH1R's endosomal signaling, and promoting PTH1R-mediated catabolic response and bone remodeling.
PTH1R mutation causing primary failure of tooth eruption in a consanguineous Saudi family.
A critical role for SNX27 (zeige SNX27 Antikörper)-retromer mediated transport of PTHR in normal bone development.
PI3K (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper) pathway stimulates the expressions of RANKL (zeige TNFSF11 Antikörper), PTHrP, and BMP-2 (zeige BMP2 Antikörper) partly through NF-kappaB (zeige NFKB1 Antikörper), suggesting its importance for bone metastasis of prostate carcinoma
Pth1r in DMP1 (zeige DMP1 Antikörper)-8kb-expressing cells is required to maintain basal levels of bone resorption but is dispensable for the catabolic action of chronic PTH (zeige PTH Antikörper) elevation.
Results provide in vivo evidence of a role for RAMP2 (zeige RAMP2 Antikörper) in placental development distinct from the RAMP2 (zeige RAMP2 Antikörper)-calcitonin receptor-like receptor (zeige CALCRL Antikörper)/adrenomedullin (zeige ADM Antikörper) signaling paradigm; decreases Pthr1 expression and causes a blunted response to systemic parathyroid hormone (zeige PTH Antikörper); and identify additional pathways underlying the endocrine and fertility defects of the previously characterized Ramp2 (zeige RAMP2 Antikörper) heterozygous adult females.
Activation of PTHrP-cyclic AMP (zeige TMPRSS5 Antikörper)-CREB1 (zeige CREB1 Antikörper) signaling following p53 (zeige TP53 Antikörper) loss is essential for osteosarcoma initiation and maintenance.
PTHrP and PTH (zeige PTH Antikörper) mediate wasting through a common mechanism involving PTHR.
we propose that PTH (zeige PTH Antikörper) has a direct effect on osteoblasts and osteoclasts, and that this effect is mediated through PTH1R, thus contributing to bone remodeling
Ihh (zeige IHH Antikörper) and PTH1R signaling in limb mesenchyme are both essential to regulate proper development of digit structures, although they appear to use different mechanisms.
cells expressing osterix (zeige SP7 Antikörper) are mesenchymal progenitors contributing to all relevant cell types during morphogenesis.
PTH1R regulates systemic mineral ion homeostasis and induction of FGF23 (zeige FGF23 Antikörper).
PTH1R is an important component of mechanical signal transduction in osteocytic MLO-Y4 cells.
Loss of function of either PTHR1 or PTHrP in zebrafish leads to a localized aortic defect that is Notch (zeige NOTCH1 Antikörper) dependent.
The expression of the PTH/PTHrP receptor in dairy cows before and after parturition is reported.
This study reveals clear genetic-statistical evidence for a link of KRT8 (zeige KRT8 Antikörper), FAF1 (zeige FAF1 Antikörper) and PTH1R with some of leg weakness related traits in pigs.
These findings reveal that direct ezrin interactions promote PTH1R apical localization and signaling in LLC-PK1 cells.
PTHLH and PTHR1 were evaluated as functional candidate genes for their effects on number and shape of teats in pigs
The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene.
, PTH/PTHrP type I receptor
, PTH1 receptor
, parathyroid hormone receptor 1
, parathyroid hormone/parathyroid hormone-related peptide receptor
, parathyroid hormone/parathyroid hormone-related protein receptor
, seven transmembrane helix receptor
, PTH-related peptide receptor
, PTH/PTHrP receptor
, parathyroid hormone 1 receptor
, parathyroid hormone/parathyroid hormone-related peptide receptor-like
, parathyroid hormone receptor-1
, parathyroid receptor
, LOW QUALITY PROTEIN: parathyroid hormone/parathyroid hormone-related peptide receptor
, Parathyroid hormone/parathyroid hormone-related peptide receptor