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Here is presented a novel O-GlcNAc transferase (OGT), EOGT (zeige C3orf64 Proteine), responsible for extracellular O-linked-N-acetylglucosamine acylation.
study found that the super sex combs (sxc)gene encodes O-linked N-acetylglucosamine transferase (Ogt); Polycomb (zeige CBX2 Proteine) repression appears to be a critical function of Sxc/Ogt in Drosophila and may be mediated by the glycosylation of Polyhomeotic
Developmental regulation of zOGT transcriptional variants generated by alternative splicing and characterization of their OGT activities of protein O-GlcNAcylation.
Overexpression of Ogt delayed epiboly and caused a severe disorganization of the microtubule and actin based cytoskeleton in the extra-embryonic yolk syncytial layer.
Hsp90 is involved in the regulation of OGT and O-GlcNAc modification and that Hsp90 inhibitors might be used to modulate O-GlcNAc modification and reverse its adverse effects in human diseases.
OGT, a unique glycosyltransferase (zeige GTDC2 Proteine) enzyme, was identified to be upregulated in non-alcoholic fatty liver disease-associated hepatocellular carcinoma tissues by transcriptome sequencing. Here, we found that OGT plays a role in cancer by promoting tumor growth and metastasis in cell models. This effect is mediated by the induction of palmitic acid.
Nrf1 is regulated by O-GlcNAc transferase.
Findings indicate O-linked N-acetylglucosamine transferase (OGT) as a cellular factor involved in human papillomaviruses type 16/18 E6 and E7 expressions and cervical cancer tumorigenesis, suggesting that targeting OGT in cervical cancer may have potential therapeutic benefit.
The findings suggest that OGT promotes the O-GlcNAc modification of HDAC1 (zeige HDAC1 Proteine) in the development of progression hepatocellular carcinoma.
Tax (zeige CNTN2 Proteine) interacts with the host OGT/OGA (zeige MGEA5 Proteine) complex and inhibits the activity of OGT-bound OGA (zeige MGEA5 Proteine).
We identified two human PRC2 complexes and two PR-DUB deubiquitination complexes, which contain the O-linked N-acetylglucosamine transferase OGT1 and several transcription factors.
Mutations in N-acetylglucosamine (O-GlcNAc) transferase in patients with X-linked intellectual disability
This work uncovers that URI-regulated OGT confers c-MYC (zeige MYC Proteine)-dependent survival functions in response to glucose fluctuations.
The results of this study showed that the OGT is essential for sensory neuron survival and target innervation.
The authors show that O-GlcNAcylation of KEAP1 (zeige KEAP1 Proteine) by OGT at serine 104 is required for the efficient ubiquitination and degradation of NRF2 (zeige GABPA Proteine).
Data suggest that enzymes in hexosamine biosynthesis pathway and downstream protein O-GlcNAcylation are important for preimplantation development (zeige MTA2 Proteine); these include Ogt, Gfpt (glutamine (zeige GFPT1 Proteine)-fructose-6-P aminotransferase), and Oga (O-GlcNAcase (zeige MGEA5 Proteine)).
Data show that postsynaptic deletion of O-GlcNAc transferase (OGT) leads to fewer morphological synapses.
miR (zeige MLXIP Proteine)-24-1 may regulate mouse hepatocarcinoma cells migration and invasion, at least partially through targeting OGT.
O-GlcNAc modification is essential for cold-induced thermogenesis and mitochondrial biogenesis in brown adipose tissue.
This study identifies OGT activity as an important regulator of SC functions such as myelin maintenance and axonal support.
cullin 3 (CUL3 (zeige CUL3 Proteine)), a cullin family E3 ubiquitin ligase (zeige MUL1 Proteine), down-regulates the expression of the O-GlcNAc transferase (OGT) and inhibits STAT3 (zeige STAT3 Proteine) O-GlcNAcylation.
OGT functions in metastatic spread of HPV E6/E7-positive tumor cells to the lungs through E6/E7, HCF-1 (zeige HCFC1 Proteine) and CXCR4 (zeige CXCR4 Proteine)
Furthermore, both Ogt and Oga (zeige MGEA5 Proteine) were required for the reversion from primed ESD (zeige ESD Proteine)-EpiSCs to naive rESCs. These findings indicate that O-GlcNAcylation plays an important role in the survival of primed ESD (zeige ESD Proteine)-EpiSCs and in their reversion to naive rESCs.
Beyond its well-known role in adding beta-O-GlcNAc to serine and threonine residues of nuclear and cytoplasmic proteins, OGT also acts as a protease in the maturation of the cell cycle regulator, HCF-1 (zeige HCFC1 Proteine), and serves as an integral member of several protein complexes, many of them linked to gene expression. (Review)
the O-linked N-acetylglucosamine (O-GlcNAc) processing enzymes, O-GlcNAc-transferase (OGT) and O-GlcNAcase (OGA (zeige MGEA5 Proteine)), interact with the (A)gamma-globin (zeige HBG1 Proteine) promoter at the -566 GATA repressor (zeige ZBTB32 Proteine) site
This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
, O-linked GlcNAc transferase
, UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase
, O-linked N-acetylglucosamine transferase
, lethal (2) NC130
, O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 1
, copy I
, UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
, o-linked GlcNAc transferase
, TPR repeat-containing protein
, UDP-N-acetylglucosamine:peptide N-acetylglucosaminyltransferase
, O linked N-acetylglucosamine transferase
, O-GlcNAc transferase subunit p110
, O-linked N-acetylglucosamine transferase 110 kDa subunit
, UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase
, O-GlcNAc transferase p110 subunit
, uridinediphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyl transferase
, O linked N-acetylglucosamine transferase like