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These findings reveal spectrin (alpha/beta) / ankyrin B (zeige ANK2 Antikörper) cytoskeletal and signaling proteins as key regulators of T-type calcium channels expressed in the nervous system.
This study demonstrates that the FGF19 (zeige FGF19 Antikörper)-SHP (zeige LAMC1 Antikörper)-LSD1 (zeige KDM1A Antikörper) axis maintains homeostasis by suppressing unnecessary autophagic breakdown of cellular components, including lipids, under nutrient-rich postprandial conditions.
a new function for spectrins in the stability of invadosomes and the coupling between actin regulation and ECM (zeige MMRN1 Antikörper) degradation
Calcium plays a role in regulating the expression and function of beta-adducin to sustain normal organization of the spectrin-based cytoskeleton and the differentiation properties in keratinocytes through the calmodulin/EGFR/cadherin signaling pathway.
organization of a spectrin-like cytoskeleton is associated with keratinocyte differentiation, and cytoskeleton disruption is mediated by either PKCdelta (zeige PKCd Antikörper)(Thr505) phosphorylation associated with phosphorylated adducin or due to reduction of endogenous adducin
Results of this study provide evidence for a role for spectrin in different steps of megakaryocyte development through its participation in the formation of invaginated membranes and in the maintenance of proplatelet structure.
Analysis of 3 new alleles reveals previously unknown consequences of red blood cell (RBC (zeige CACNA1C Antikörper)) spectrin deficiency, resulting in markedly reduced RBC (zeige CACNA1C Antikörper) membrane spectrin content, decreased band 3 (zeige SLC4A1 Antikörper), and absent beta-adducin (zeige ADD2 Antikörper).
Murine recessive hereditary spherocytosis, sph/sph, is caused by a mutation in the erythroid alpha-spectrin gene.
a novel HE case with a His54Pro mutation in the SPTA1 gene was reported. The results suggested that the His54Pro mutation influenced the role of erythrocyte membrane proteins without reducing its level of expression.
A novel SPTA1 mutation (H54P) was identified in a case of hereditary elliptocytosis.
The authors show that SUB1-mediated processing of MSP1 is important for parasite viability, the processing modifies the secondary structure of MSP1 and activates its capacity to bind spectrin.
The authors demonstrate that the initial vacuolar membrane around internalized Babesia divergens is formed from protein and lipid components of the red blood cells plasma membrane, including band 3, glycophorin A and spectrin.
Case Report: severe hemolytic jaundice and a phenotype of hereditary spherocytosis due alpha-spectrin (zeige SPTAN1 Antikörper) mutations.
In this review, we summarize the state of knowledge about interactions between spectrin and membrane lipids
A novel exon 2 alpha spectrin (zeige SPTAN1 Antikörper) mutation is identified in two families of European ancestry with hereditary pyropoikilocytosis.
The heterozygous c.121C>T mutation of SPTA1 gene induces an amino acid change p.Arg41Trp in the alpha1 domain of the alpha-spectrin (zeige SPTAN1 Antikörper) protein.
Data show that transcription cofactor TAF3 (zeige TAF3 Antikörper) is required for transcription of the alpha spectrin (zeige SPTAN1 Antikörper) SPTA1 gene.
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia.
erythroid spectrin alpha
, spectrin alpha chain, erythrocyte
, alpha-spectrin 1, erythroid
, erythroid alpha-spectrin
, hemolytic anemia
, neuroscience mutagenesis facility, 4
, spectrin alpha 1
, spectrin alpha chain, erythrocytic 1
, alpha-I spectrin