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RCAN1 Produkte

(Regulator of Calcineurin 1 (RCAN1))

Kategorien

The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Ausgewählte RCAN1 Kategorien

RCAN1 Antikörper

High quality antibodies with extensive validation data.

RCAN1 ELISA Kits

Reliable ELISA kits for a wide range of species.

RCAN1 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene RCAN1 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, IHC
Validierungen
  • (7)
Kat. Nr. ABIN6146811
Menge 100 μL
Datenblatt Datenblatt

Applikation WB
Validierungen
  • (1)
  • (6)
Kat. Nr. ABIN2780590
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, ELISA, IF
Validierungen
  • (1)
  • (3)
Kat. Nr. ABIN515079
Menge 100 μg
Datenblatt Datenblatt

Empfohlene RCAN1 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6959092
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN5593142
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Rat
Analytical Method
Validierungen
Kat. Nr. ABIN2870488
Menge 96 tests
Datenblatt Datenblatt

Empfohlene RCAN1 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1317677
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1317675
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
  • (1)
Kat. Nr. ABIN3086941
Menge 1 mg
Datenblatt Datenblatt

Neueste Publikationen zu unseren RCAN1 Produkten

Wang, Rai, Hur, Smilansky, Chang, Min: "DSCR1 is required for both axonal growth cone extension and steering." in: The Journal of cell biology, Vol. 213, Issue 4, pp. 451-62, (2017) (PubMed).

Lei, Hu, Chen, Yu, Qi, Du, Gu, Lin, Yang: "RCAN1 deficiency protects against Salmonella intestinal infection by modulating JNK activation." in: Molecular immunology, Vol. 77, pp. 26-33, (2017) (PubMed).

Hong, Lee, Chung: "Ubiquitin-specific protease 22 (USP22) positively regulates RCAN1 protein levels through RCAN1 de-ubiquitination." in: Journal of cellular physiology, Vol. 230, Issue 7, pp. 1651-60, (2015) (PubMed).

Lee, Kim, Lee, Baek, Seo: "Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) Targets Down Syndrome Candidate Region 1 (DSCR1/RCAN1) to control Neuronal Differentiation." in: The Journal of biological chemistry, Vol. 290, Issue 34, pp. 21019-31, (2015) (PubMed).

Xing, Salas, Zhang, Gittler, Ludwig, Lin, Murty, Silverman, Arancio, Tycko: "Creation and characterization of BAC-transgenic mice with physiological overexpression of epitope-tagged RCAN1 (DSCR1)." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 24, Issue 1-2, pp. 30-43, (2013) (PubMed).

Junkins, MacNeil, Wu, McCormick, Lin: "Regulator of calcineurin 1 suppresses inflammation during respiratory tract infections." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 190, Issue 10, pp. 5178-86, (2013) (PubMed).

Stefos, Soppa, Dierssen, Becker: "NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect." in: PLoS ONE, Vol. 8, Issue 6, pp. e67470, (2013) (PubMed).

Voronov, Ochotny, Jaumouillé, Owen, Manolson, Aubin: "The R740S mutation in the V-ATPase a3 subunit increases lysosomal pH, impairs NFATc1 translocation, and decreases in vitro osteoclastogenesis." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 28, Issue 1, pp. 108-18, (2012) (PubMed).

Wang, Zhu, Chang, Min: "DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis." in: The EMBO journal, Vol. 31, Issue 18, pp. 3655-66, (2012) (PubMed).

Kim, Seo: "The regulator of calcineurin 1 (RCAN1/DSCR1) activates the cAMP response element-binding protein (CREB) pathway." in: The Journal of biological chemistry, Vol. 286, Issue 43, pp. 37841-8, (2011) (PubMed).

Synonyme und alternative Namen zu RCAN1

regulator of calcineurin 1 (RCAN1), regulator of calcineurin 1 (Rcan1), regulator of calcineurin 1b (rcan1b), regulator of calcineurin 1 L homeolog (rcan1.L), Down syndrome critical region gene 1 (dscr1), regulator of calcineurin 1 (rcan1), 2410048A02Rik, AA408855, ADAPT78, Adapt78, adapt78, AI429645, AL024459, AV028423, CALP1L, CSP1, csp1, DSC1, dsc1, DSCR1, Dscr1, dscr1, MCIP1, Mcip1, mcip1, MGC53636, MGC69428, RCAN1, rcan1, RCN1, rcn1, wu:fr92c05

Bezeichner auf Proteinebene für RCAN1

  • Down syndrome candidate region 1
  • Down syndrome critical region gene 1
  • calcipressin-1
  • calcium and oxidant-inducible mRNA
  • down syndrome critical region protein 1
  • modulatory calcineurin-interacting protein 1
  • myocyte-enriched calcineurin-interacting protein 1
  • near DSCR proline-rich protein
  • calcipressin 1
  • down syndrome critical region protein 1 homolog
  • regulator of calcineurin 1
  • Down syndrome critical region homolog 1
  • calcineurin inhibitor
  • myocyte-enriched calcineurin interactin protein 1
  • Down syndrome critical region protein 1 homolog
  • Oxidative-induced protein Adapt78
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