PUMA Proteine
(BCL2 Binding Component 3 (BBC3))
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011].
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BBC3
Spezies: Human
Wirt: Escherichia coli (E. coli)
Recombinant
Greater than 90 % by SDS-PAGE gel analyses
WB, ELISA
1 image
BBC3
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
> 80 % as determined by SDS-PAGE and Coomassie blue staining
AbP, STD
1 image
1 reference
BBC3
Spezies: Human
Wirt: Escherichia coli (E. coli)
Recombinant
> 90 % as determined by reducing SDS-PAGE.
Imm
BBC3
Spezies: Human
Wirt: Escherichia coli (E. coli)
Recombinant
WB, SDS, ELISA
BBC3
Spezies: Ratte
Wirt: Escherichia coli (E. coli)
Recombinant
> 95 %
WB, SDS, Imm, PC
custom-made
BBC3
Spezies: Maus
Wirt: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
custom-made
BBC3
Spezies: Human
Wirt: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
BBC3
Spezies: Human
Wirt: Escherichia coli (E. coli)
Recombinant
~95 %
WB, ELISA, MS
1 image
BBC3
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
> 80 % as determined by SDS-PAGE and Coomassie blue staining
AbP, STD
1 image
Aktuelle Publikationen für unsere PUMA Proteine
: "HER2 phosphorylates and destabilizes pro-apoptotic PUMA, leading to antagonized apoptosis in cancer cells." in: PLoS ONE, Vol. 8, Issue 11, pp. e78836, (2013) (PubMed).Aliase für PUMA Proteine
BCL2 binding component 3 (BBC3) ProteineBcl-2 binding component 3 (Bbc3) Proteine
BCL2 binding component 3 (Bbc3) Proteine
BCL2 binding component 3 (bbc3) Proteine
BBC3 Proteine
JFY-1 Proteine
JFY1 Proteine
Puma Proteine
PUMA Proteine
PUMA/JFY1 Proteine
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- PUSL1 Proteine
- PVALB Proteine
- PVRIG Proteine
- PVRL1 Proteine
- PVRL2 Proteine
- PVRL3 Proteine
- PVRL4 Proteine
- PWP1 Proteine
- PXK Proteine
- PYCARD Proteine
- PYCR1 Proteine
- PYCR2 Proteine
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