IL-2 Protein

Produktnummer ABIN988056

Produktdetails

Target: IL-2 (IL2) (Interleukin 2 (IL2))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Wirt: Bitte anfragen

Sequenz: analysis The sequence of the first five N-terminal amino acids has been found to be Met-Pro-Thr-Ser-Ser. p to grams level.

Produktmerkmale: The specific activity as determined and was found to be greater than 1.0×107 IU/mg.

Reinheit: > 98 % as determined by the following methods:(a) SEC-HPLC analysis(b) Reducing and non-reducing SDS-PAGE silver-stained gel analysis

Endotoxin-Niveau: Level Less than 0.1 ng/myg (1 IEU/myg) determined by LAL tes

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: It is recommended to reconstitute the lyophilized Recombinant Human Interleukin-2 (IL-2) in sterile 18 M-omega-cm H2O not less than 100 myg/ml, which can then be further diluted to other aqueous solutions.

Lagerung: -20 °C

Referenzen

Webster, Zufferey, Pane, Coulson: "Alteration of the thymic T cell repertoire by rotavirus infection is associated with delayed type 1 diabetes development in non-obese diabetic mice." in: PLoS ONE, Vol. 8, Issue 3, pp. e59182, (2013) (PubMed).

Suzuki, Jagger, Konya, Shimojima, Pryshchep, Goronzy, Weyand: "CD8+CD45RA+CCR7+FOXP3+ T cells with immunosuppressive properties: a novel subset of inducible human regulatory T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 5, pp. 2118-30, (2012) (PubMed).

Antigendetails

Target: IL-2 (IL2) (Interleukin 2 (IL2))

Andere Bezeichnung: Interleukin-2 (IL-2) (IL2 Produkte)

Synonyme: IL2 Protein, IL-2 Protein, il2 Protein, TCGF Protein, lymphokine Protein, Il-2 Protein, POIL2 Protein, interleukin 2 Protein, interleukin-15 Protein, IL2 Protein, il2 Protein, LOC100303688 Protein, Il2 Protein

Hintergrund: In vitro studies performed on human cell lines demonstrate the immunoregulatory properties of Interleukin-2 (IL-2) including: 1) enhancement of lymphocyte mitogenesis and stimulation of long-term growth of human Interleukin-2 (IL-2) dependent edll lines, 2) enhancement of lymphocyte cytotoxicity, 3) induction of killer cell (lymphokine-activated (LAK) and natural (NK)) activity, 4) induction of interferon-gamma production. Human Interleukin-2 (IL-2) is a highly purified protein with a molecular weight of approximately 15,300 Da. The chemical name is des-alanyl-1, serine-125 human interleukin-2. It is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human Human Interleukin-2 (IL-2) gene. Genetic engineering techniques were used to modify the human Interleukin-2 (IL-2) gene, and the resulting expression clone encodes a modified human Interleukin-2 (IL-2). This recombinant form differs from native Interleukin-2 (IL-2) in following ways: 1) it is not glycosylated, 2) the molecule has no N-terminal alanine, 3) the molecule has serine substituted for cysteine at amino acid position 125, 4) the aggregation state of molecule is likely to be different from that of native Interleukin-2 (IL-2). Synonym: rHuIL-2, rHuIL2 zoom, Interleukin-2, Interleukin. Formulation: The protein was lyophilized after extensive dialysis against 50mM Phosphate buffer, pH7.5, 5% Mannitol buffer.

Molekulargewicht: 15,300 Da Isoelectric Point The main zone between 6.5-7.5 analysis by IEF

Pathways: JAK-STAT Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation